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| 1 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 2 | Studies on inverter-fed five-phase induction motor drive 显示文摘 | Pavithran K N Parimelalagan R Krishnamurthy M R | 1988 | IEEE Power Elec1988，3，2： | 2 |
| 3 | Determination of sulfonylurea herbicides by capillary electroehromatography 显示文摘 | BASAVAIAH K KRISHNAMURTHY G | 1999 | Anal Sci1999，15，： | 1 |
| 4 | Change management for collaborative engineering显示文摘 | Law K H | 1995 | Computing in Civil Engineering1995，2，： | 1 |
| 5 | Control of low velocity friction and gear backlash in a machine tool feed drive system显示文摘 | Menon K Krishnamurthy K | 1999 | Mechatronics1999，，9： | 1 |
| 6 | Development of improved method to quantify maldistribution and its effect on structured packing column performance显示文摘 | EDWARDS D P KRISHNAMURTHY K R POTFHOFF R W | 1999 | Trans IChemE1999，77，： | 1 |
| 7 | Studies on inverter-fed five-phase induction motor drive显示文摘 | Pavithran K N Parimelalagan R Krishnamurthy M R | 1988 | IEEE Transactions on PowerElectronics1988，3，2： | 1 |
| 8 | Palaeoclimatic changes deduced from ^13C/^12C and C/N ratios of Karewa lake sediments,India显示文摘 | Krishnamurthy R V Bhattacharya S K Kusumgar S | 1986 | Nature1986，323，： | 1 |
| 9 | Nucleotide sequences of the trailer, nucleocapsid protein gene and intergenic regions of Newcastle disease virus strain Beaudette C and completion of the entire genome sequence 显示文摘 | Krishnamurthy S Samal K | 1998 | J Gen Virol1998，79，： | 1 |
| 10 | Response of nicotiana species and varieties to the root-knot nematode Meloidogyne javanica 显示文摘 | Ramjial Nagarajan K Krishnamurthy GVG | 1986 | To- bacoo Research1986，14，2： | 1 |
| 11 | Structural health monitoring of composite structures using Lamb wave tomography显示文摘 | Prasad S M Balasubramaniam K Krishnamurthy C V | 2004 | Smart Materials and Struc tures2004，13，5： | 1 |
| 12 | wideband radio propagation modeling for indoor geolocation applications 显示文摘 | Pahlavan K Krishnamurthy P Beneat J | 1998 | IEEE Communications Magazine1998，，： | 1 |
| 13 | Nucleotide sequences of the trailer, nucleocapsid protein gene and intergenic regions of Newcastle disease virus strain Beaudette C and completion of the entire genome sequence显示文摘 | Krishnamurthy S Samal S K | 1998 | Journal of General Virology1998，79，： | 1 |
| 14 | Epidemiology of cancer of the cervix: global and national perspec- tive显示文摘 | SHANTA V KRISHNAMURTHI S GAJALAKSHMI C K | 2000 | J Indian Med Assoc2000，98，2： | 1 |
| 15 | Microscopic and spectroscopy evaluation of inactivation of Staphylococcus aureus by pulsed UV light and infrared heating显示文摘 | Krishnamurthy K Tewari J C Irudayaraj J | 2010 | Food and Bioprocess Technology2010，3，1： | 1 |
| 16 | Transforming growth factor-betal and TGF-beta2 act synergisti- cally in the fibrotic pathway in oral submucous fibrosis: an im- munohistochemical observation显示文摘 | KAMATH V V KRISHNAMURTHY S SATELUR K P | 2015 | Indian J Med Paediatr Oncol2015，36，2： | 1 |
| 17 | Analysis of WLAN' s Received Signal Strength Indication for Indoor Location Fingerprinting 显示文摘 | KAEMARUNGSI K KRISHNAMURTHY P | 2012 | Pervasive and Mobile Com- puting2012，，8： | 1 |
| 18 | Biological control of rice blast by Pseudomonasfluorescens strain Pf7-14: evaluation of a maker gene and formulations显示文摘 | Krishnamurthy K Gnanamanickam S S | 1998 | Biological Control1998，13，： | 1 |
| 19 | Change management for collaborative engineering显示文摘 | Krishnamurthy K Law K H | 1995 | Computing in Civil Engineering1995，2，： | 1 |
| 20 | Control of low velocity friction and gear backlash in a machine tool feed drive system显示文摘 | Menon K Krishnamurthy K | 1999 | Mechatronics1999，，9： | 1 |
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