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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Developing a donation after cardiac death risk index for adult and pediatric liver transplantation显示文摘AIM To identify objective predictive factors for donor after cardiac death(DCD) graft loss and using those factors, develop a donor recipient stratification risk predictive model that could be used to calculate a DCD risk index(DCD-RI) to help in prospective decision making on organ use.METHODS The model included objective data from a single institute DCD database(2005-2013, n = 261). Univariate survival analysis was followed by adjusted Cox-regressional hazard model. Covariates selected via univariate regression were added to the model via forward selection, significance level P = 0.3. The warm ischemic threshold was clinically set at 30 min. Points were given to each predictor in proportion to their hazard ratio. Using this model, the DCD-RI was calculated. The cohort was stratified to predict graft loss risk and respective graft survival calculated.RESULTS DCD graft survival predictors were primary indication for transplant(P = 0.066), retransplantation(P = 0.176), MELD > 25(P = 0.05), cold ischemia > 10 h(P = 0.292) and donor hepatectomy time > 60 min(P = 0.028).According to the calculated DCD-RI score three risk classes could be defined of low(DCD-RI < 1), standard(DCD-RI 2-4) and high risk(DCD-RI > 5) with a 5 years graft survival of 86%, 78% and 34%, respectively.CONCLUSION The DCD-RI score independently predicted graft loss(P < 0.001) and the DCD-RI class predicted graft survival(P < 0.001). | Shirin Elizabeth Khorsandi Emmanouil Giorgakis Hector Vilca-Melendez John O'Grady Michael Heneghan Varuna Aluvihare Abid Suddle Kosh Agarwal Krishna Menon Andreas Prachalias Parthi Srinivasan Mohamed Rela Wayel Jassem Nigel Heaton | 2017 | World Journal of Transplantation2017，7，3： | 3 |
| 3 | Patient satisfaction after MRCP and ERCP显示文摘 | Krishna Menon Alan N Barkun Joseph Romagnuolo Gad Friedman Shailesh N Mehta Caroline Reinhold Patrice M Bret | 2001 | The American Journal of Gastroenterology2001，，9： | 1 |
| 4 | New variation of median arcuate ligament compression causing hepatic arterial hypoperfusion during liver transplantation显示文摘Satisfactory blood flow after hepatic arterial anastomosis in liver transplantation is a critical point of the operation.Problems with this anastomosis can result in hepatic artery thrombosis with resultant graft failure and patient morbidity and mortality.Causes of hepatic artery thrombosis include problematic technique,hepatic artery dissection,external compression(e.g.from hematoma),hypercoagulable state,splenic arterial steal and rarer causes such as median arcuate ligament compression(MALC).A careful review of preoperative radiology and imaging will reveal these rare instances and enable a proper intraoperative plan. | Noel Cassar Stephen Gregory Krishna Menon | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 1 |
| 5 | Modulation of adipogenesis and glucose uptake by Curcuma longa extract in 3T3L1 and L6 cell lines – An in vitro study显示文摘 | A. Prathapan Mahesh S Krishna P.C Lekshmi K.G Raghu A. Nirmala Menon | 2012 | Asian Pacific Journal of Tropical Disease2012，，： | 1 |
| 6 | Mid-infrared quasi-BIC resonances with sub-wavelength slot mode profiles in germanium-based coupled guided-mode resonance structures显示文摘We experimentally demonstrate a novel quasi-bound state in the continuum(BIC) resonance in the mid-infrared wavelength region with the resonant electric field confined as a slot mode within a low-refractive-index medium sandwiched between high-index layers.The structures studied here comprise coupled amorphous germanium guided-mode resonance(GMR) structures with a top one-dimensional grating layer and bottom uniform layer separated by a low-index silicon nitride layer.The slot-mode profile within the silicon nitride layer with mode field confinement >30% is achieved as a solution to the electromagnetic wave propagation through the coupled GMR structure with the dominant field component being perpendicular to the layers.The quasi-BIC resonance in symmetric 1D grating structures can be observed even at normal incidence when considering a realistic excitation beam with finite angular spread.The measured transmission peak is found to redshift(remain almost unchanged)under classical(full-conical) mounting conditions.The highest quality factor of ~400 is experimentally extracted at normal incidence under a classical mounting condition with a resonance peak at 3.41 μm wavelength.Such slot-mode GMR structures with appropriately chosen low-index intermediate layers can find applications in resonantly enhanced sensing and active photonic devices. | A.S.LAL KRISHNA SRUTI MENON ASISH PROSAD VARUN RAGHUNATHAN | 2022 | Photonics Research2022，10，1： | 0 |
| 7 | Artery of Percheron occlusion:role of diffusion-weighted imaging in the early diagnosis显示文摘Bilateral thalamic infarcts have a low frequency among different subtypes of strokes.Since it does not involve a particular vascular territory,it therefore usually involves the occlusion of the artery of Percheron(AOP).Here we report a 79-year-old right-handed Parkinsonian female patient,who was found unresponsive in bed.On examination,the patient was drowsy with a Glasgow Coma Score(GCS)of 10/15(E2M5V3).She had absent doll’s eye response with anisocoric pupils and intermittent vertical gaze palsy.Although the patient had no apparent motor deficits,she was in a state of persistent somnolence with memory impairment and lack of initiative.Diffusion-weighted magnetic resonance imaging(MRI)of the brain showed focal areas of restricted diffusion in the medial part of the thalami bilaterally and the rostral part of mid-brain(right>left)(bilateral paramedian thalamic with mid-brain pattern),suggestive of a hyper-acute infarct in the territory of AOP.The patient was anticoagulated with 40 mg subcutaneous low molecular weight heparin and was started on double anti-platelets along with supportive measures.The level of consciousness is improved at a slow rate to a GCS of 12/15(E4M5V3).The patient had marked abulia with periods of drowsiness interspersed with periods of restlessness and uttering of abnormal sounds,but she was able to execute simple commands.In conclusion,occlusion of the AOP is a rare cause of coma in elderly patients.Diffusion-weighted MRI is the imaging modality of choice for early diagnosis.Early diagnosis of AOP occlusion may lead to favorable outcomes. | Murali Krishna Menon Suma Mariam Jacob Muhammed Jasim Abdul Jalal | 2016 | Neuroimmunology and Neuroinflammation2016，3，1： | 0 |
| 8 | Spontaneous intracranial hypotension complicated with cerebral venous thrombosis and subdural effusion:a case report显示文摘Spontaneous intracranial hypotension treatment can be complicated by concomitant cerebral venous thrombosis and subdural hematoma.A 48 years old male,presenting orthostatic headache and neck pain for 1 month displayed sagittal sinus thrombosis and bilateral subdural effusions,as well as extradural fluid collection at T3-T8 level,upon magnetic resonance imaging.Cerebrospinal fluid opening pressure was 50 mmH2O,and a leak was confirmed at C2-C3 level by computed tomography(CT)myelogram.The presence of subdural hematoma precluded anticoagulation treatments.An autologous epidural blood patch at C2-C3 level under CT guidance improved the patient’s condition,remaining free of residual symptoms or recurrence at six-month follow-up. | Murali Krishna Menon Thara Prathap Muhammed Jasim Abdul Jalal | 2016 | Neuroimmunology and Neuroinflammation2016，3，1： | 0 |
| 9 | Decompressive craniectomy in herpes simplex encephalitis显示文摘Intracranial hypertension is a common cause of morbidity in herpes simplex encephalitis(HSE).HSE is the most common form of acute viral encephalitis.Hereby we report a case of HSE in which decompressive craniectomy was performed to treat refractory intracranial hypertension.A 32-year-old male presented with headache,vomiting,fever,and focal seizures involving the right upper limb.Cerebrospinal fluid-meningoencephalitic profile was positive for herpes simplex.Magnetic resonance image of the brain showed swollen and edematous right temporal lobe with increased signal in gray matter and subcortical white matter with loss of gray,white differentiation in T2-weighted sequences.Decompressive craniectomy was performed in view of refractory intracranial hypertension.Decompressive surgery for HSE with refractory hypertension can positively affect patient survival,with good outcomes in terms of cognitive functions. | Muhammed Jasim Abdul Jalal Shirley Joan Fernandez Prithvi Varghese Murali Krishna Menon | 2015 | Neuroimmunology and Neuroinflammation2015，2，1： | 0 |
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