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| 1 | Diagnosis and management of insulinoma显示文摘Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general population.Common autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and coma.Diagnosis of suspected cases is based on standard endocrine tests,especially the prolonged fasting test.Non-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin secretion.Invasive modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization techniques.The range of techniques available for the localization of insulinomas means thatblind resection can be avoided.Intraoperative manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with surgery.In patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of life.In patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life. | Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi Ito Yasuhiro Ogawa Michiya Kobayashi Kazuhiro Hanazaki | 2013 | World Journal of Gastroenterology2013，19，6： | 78 |
| 2 | Comparison of pancreatic acinar cell carcinoma and adenocarcinoma using multidetector-row computed tomography显示文摘AIM:To distinguish acinar cell carcinoma(ACC)from pancreatic adenocarcinoma(AC)by comparing their computed tomography findings.METHODS:Patients with ACC and AC were identified on the basis of results obtained using surgically resected pancreatectomy specimens.The preoperative computer tomographic images of 6 acinar cell carcinoma patients and 67 pancreatic adenocarcinoma patients in 4 phases(non-contrast,arterial,portal venous,and delayed phase)were compared.The scan delay times were 40,70,and 120 s for each contrast-enhanced phase.The visual pattern,tomographic attenuation value,and time attenuation curve were assessed and compared between AC and ACC cases using the 2test,Wilcoxon signed-rank test,and Mann Whitney U test.RESULTS:The adenocarcinomas tended to be hypodense in all 4 phases.The acinar cell carcinomas also tended to be hypodense in the 3 contrast-enhancedphases,although their computed tomographic attenuation values were higher.Further,5 of the 6 acinar cell carcinomas(83%)were isodense in the non-contrast phase.The time attenuation curve of the adenocarcinomas showed a gradual increase through the 4 phases,and all adenocarcinomas showed peak enhancement during the delayed phase.The time attenuation curve of the acinar cell carcinomas showed peak enhancement during the portal venous phase in 4 cases and during the arterial phase in 2 cases.None of the 6 acinar cell carcinomas showed peak enhancement during the delayed phase.CONCLUSION:The tumor density in the non-contrast phase and time attenuation curve pattern clearly differ between acinar cell carcinomas and adenocarcinomas,and multidetector-row computed tomography can thus distinguish these tumors. | Tatsuaki Sumiyoshi Yasuo Shima Takehiro Okabayashi Akihito Kozuki Toshio Nakamura | 2013 | World Journal of Gastroenterology2013，19，34： | 5 |
| 3 | CT/^(99m)Tc-GSA SPECT fusion images demonstrate functional differences between the liver lobes显示文摘AIM: To evaluate the functional differences between the 2 liver lobes in non-cirrhotic patients by using computed tomography/99mTc-galactosyl human serum albumin (CT/99mTc-GSA) single-photon emission computed tomography (SPECT) fusion images. METHODS: Between December 2008 and March 2012, 264 non-cirrhotic patients underwent preoperative liver function assessment using CT/99mTc-GSA SPECT fusion images. Of these, 30 patients, in whom the influence of a tumor on the liver parenchyma was estimated to be negligible, were selected. Specifically, the selected patients were required to meet either of the following criteria: (1) the presence of an extrahepatic tumor; or (2) presence of a single small intrahepatic tumor. These 30 patients were retrospectively analyzed to calculate the percentage volume (%Volume) and the percentage function (%Function) of each lobe. The ratio between the %Function and %Volume (function-to-volume ratio) of each lobe was also calculated, and the ratios were compared between the 2 lobes. Furthermore, the correlations between the function-to-volume ratio and each of 2 liver parameters [lobe volume and diameter ratio of the left portal vein to the right portal vein (LPV-to-RPV diameter ratio)] were investigated. RESULTS: The median values of %Volume and %Function were 62.6% and 67.1% in the right lobe, with %Function being significantly higher than %Volume (P < 0.01). The median values of %Volume and %Function were 31.0% and 28.7% in the left lobe, with %Function being significantly lower than %Volume (P < 0.01). The function-to-volume ratios of the right lobe (1.04-1.14) were significantly higher than those of the left lobe (0.74-0.99) (P < 0.01). The function-to-volume ratio showed no significant correlation between the lobe volume in either lobe. In contrast, the function-to-volume ratio showed significant correlations with the LPV-to-RPV diameter ratio in both lobes (right lobe: negative correlation, rs = -0.37, P = 0.048; left lobe: positive correlation, r s = 0.71, P < 0.001). The function-to-volume ratio in the left lobe tended to be higher, and that in the right lobe tended to be lower, in accordance with the increase in the LPV-to-RPV diameter ratio. CONCLUSION: CT/99mTc-GSA SPECT fusion images demonstrated that the function of the left lobe was significantly decreased compared with that of the right lobe in non-cirrhotic livers. | Tatsuaki Sumiyoshi Yasuo Shima Ryoutarou Tokorodani Takehiro Okabayashi Akihito Kozuki Yasuhiro Hata Yoshihiro Noda Yoriko Murata Toshio Nakamura Kiminori Uka | 2013 | World Journal of Gastroenterology2013，19，21： | 3 |
| 4 | Combination of SN-38 with gefitinib or imatinib overcomes SN-38-resistant small-cell lung cancer cells 显示文摘 | Takigawa N Takeyama M Kozuki T | 2007 | Oncol Rep2007，17，5： | 1 |
| 5 | Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease 显示文摘 | Kurata T Miyazaki K Kozuki M | 2012 | Neurol Res2012，34，6： | 1 |
| 6 | Intrapartum-relatedneonatal encephalopathy incidence and impairment at regional andglobal levels for 2010 with trends from 1990显示文摘 | Lee A C Kozuki N Blencowe H | 2013 | Pediatr Res2013，74，： | 1 |
| 7 | Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer's disease显示文摘 | Kurata T Miyazaki K Kozuki M | 2012 | Neurol Res2012，34，6： | 1 |
| 8 | A Human Damage Prediction Method for Tsunami Disasters Incorporating Evacuation Activities 显示文摘 | Sugimoto T Murakami H Kozuki Y | 2003 | Natural Hazards2003，29，3： | 1 |
| 9 | DNA Topoisomerase II enzymesas molecular targets for cancer chemotherapy显示文摘 | Chikamori K Grozav AG Kozuki T | 2010 | Curt Cancer DrugTargets2010，10，7： | 1 |
| 10 | DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy 显示文摘 | Chikamori K Grozav AG Kozuki T | 2010 | Curr Cancer Drug Targets2010，10，7： | 1 |
| 11 | STELLIUM 1:First-in-man follow-up evaluation of bioabsorbable polymer-coated paclitaxel-eluting stent显示文摘 | Kozuki A Shite J Shinke T | | 0，，： | 1 |
| 12 | Progressive neurovascular disturbances in the cerebral cortex of Alzheimer's disease-model mice: protection by atorvastatin and pitavastatin显示文摘 | Kurata T Miyazaki K Kozuki M | 2011 | Neuroscience2011，197，： | 1 |
| 13 | Intrapartum-relatedneonatal encephalopathy incidence and impairment at re-gional and global levels for 2010 with trends from 1990显示文摘 | Lee AC Kozuki N Blencowe H | 2013 | Pediatr Res2013，741，： | 1 |
| 14 | Moderate to severe, but not mild, maternal anemia is associated with increased risk of small-for- gestational-age outcomes显示文摘 | Kozuki N Lee AC Katz J | 2012 | J Nutr2012，142，2： | 1 |
| 15 | Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-alpha显示文摘 | Kozuki M Kurata T Miyazaki K | 2011 | Brain Res2011，1388，： | 1 |
| 16 | Long-term follow-up of phase II trial of docetaxel and cisplatin with concurrent thoracic ra- diation therapy for locally advanced non-small cell lung cancer 显示文摘 | Tokuda Y Takigawa N Kozuki T | 2012 | Acta Oncologica2012，51，4： | 1 |
| 17 | Atorvastatin and pitavastatin improve cognitive function and reduce senile plaque and phosphorylated tau in aged APP mice显示文摘 | Kurata T Miyazaki K Kozuki M | 2011 | Brain Res2011，1371，： | 1 |
| 18 | Long-term effect of gefitinib (ZD1839) on squamous cell carcinoma of the lung显示文摘 | Kozuki T Kiura K Ueoka H | 2004 | Anticancer Res2004，24，： | 1 |
| 19 | DNA Topoisomerase II enzymes as molecular targets for cancer chemotherapy 显示文摘 | Chikamori K Grozav AG Kozuki T | 2010 | Curt Cancer Drug Targets2010，10，7： | 1 |
| 20 | Theoretical application of smoking cessation intervention to individuals with medical educations: women's initiative for nonsmoking(WINS)-Part Ⅲ显示文摘 | FROELICHER ES KOZUKI Y | 2002 | Int J Nurs Stud2002，39，1： | 1 |
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