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| 1 | Clinical efficacy of the over-the-scope clip device: A systematic review显示文摘BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and fistulas.Limited data exist evaluating the efficacy and safety of OTSC.AIM To determine the clinical success and adverse event(AE)rates of OTSC across all GI indications.METHODS A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI tract.Any article or case series reporting data for less than 5 total patients was excluded.The primary outcome was the rate of clinical success.Secondary outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC placement.Pooled rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of patients.RESULTS A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent fixation.AE’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent fixation.Clinical success in fistula management appears limited.Further studies,including randomized controlled trials comparing OTSC with conventional and/or surgical therapies,are needed to determine which indication(s)are the most effective for its use. | Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari Shivangi Kothari | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Massive duodenal variceal bleed; complication of extra hepatic portal hypertension: Endoscopic management and literature review显示文摘Bleeding from duodenal varices is reported to be a catastrophic and often fatal event. Most of the cases in the literature involve patients with underlying cirrhosis. However, approximately one quarter of duodenal variceal bleeds is caused by extrahepatic portal hypertension and they represent a unique population given their lack of liver dysfunction. The authors present a case where a 61-year-old male with history of remote crush injury presented with bright red blood per rectum and was found to have bleeding from massive duodenal varices. Injection sclerotherapy with ethanolamine was performed and the patient experienced a favorable outcome with near resolution of his varices on endoscopic follow-up. The authors conclude that sclerotherapy is a reasonable first line therapy and review the literature surrounding the treatment of duodenal varices secondary to extrahepatic portal hypertension. | Christopher Steevens Maisa Abdalla Truptesh H Kothari Vivek Kaul Shivangi Kothari | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 2 |
| 3 | Prospective evaluation of the hemorrhoid energy treatment for the management of bleeding internal hemorrhoids显示文摘BACKGROUND The hemorrhoid energy treatment(HET)system is a non-surgical bipolar electrotherapy device,which has previously demonstrated efficacy in the management of bleeding Grade I and II internal hemorrhoids;however,data is limited.AIM To prospectively assess the safety and efficacy of the HET device.METHODS This was an IRB-approved prospective study of 73 patients with Grade I or II internal hemorrhoids who underwent HET from March 2016 to June 2019.Patient factors and procedural data were obtained.A post-procedure questionnaire was administered by telephone to all patients at 1-wk and 3-mo following HET to assess for improvement and/or resolution of rectal bleeding and adherence to a stool softener regimen.A chart review was performed to observe recurrent symptoms and durability of response.Statistical analyses were performed using SPSS software(IBM;SPSS Version 25.0).RESULTS Seventy-three patients underwent HET during the study period.Mean post-HET follow-up was 1.89 years.Complete resolution of bleeding was reported in 65%at 1 wk(n=48),with improvement in bleeding in 97.2%(n=71)of patients.At 3-mo,resolution and/or improvement in bleeding was reported in 90%(n=64)of patients.No procedure-related pain or adverse events were reported.CONCLUSION HET is well tolerated,safe and highly effective in the majority of our patients presenting with Grade I and II symptomatic internal hemorrhoids. | Truptesh H Kothari Krystle Bittner Shivangi Kothari Vivek Kaul | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，8： | 2 |
| 4 | Contribution of VA myeorrhizal hyphae in acquisition of phosphorus and zine by maize grown in a calcareous soil 显示文摘 | Kothari S K Marschner H RomheId V | 1991 | Plant and Soil1991，131，： | 1 |
| 5 | Economic emission load dispatch with line flow constraints using a classical technique显示文摘 | Nanda J Lakshman H Kothari M L | 1994 | IEE ProceedingsGeneration Transmission and Distribution1994，141，1： | 1 |
| 6 | Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection 显示文摘 | Sen P Gopalakrishnan R Kothari H | 2011 | Blood2011，117，11： | 1 |
| 7 | Tumor necrosis factor gene polymorphism resultsin high TNF levelin sepsis and septic shock 显示文摘 | Kothari N Bogra J Abbas H | 2013 | Cytokine2013，61，2： | 1 |
| 8 | Mesophilic anaerobicdigestion:first option for waste treatment in tropical regions显示文摘 | Suryawanshi P C Chaudhari A B Kothari H M | 2010 | CriticalReviews in Biotechnology2010，30，4： | 1 |
| 9 | Inhibition of cholesterol ester transfer protein CGS 25159 and changes in lipoproteins in hamsters显示文摘 | Kothari H V Poirier K J Lee W H | 1997 | Atherosclerosis1997，128，1： | 1 |
| 10 | Classification of soil texture using remotely sensed brightness temperature over the Southern Great Plains 显示文摘 | CHANG D H KOTHARI R ISLAM S | 2003 | IEEE Transactions on Geoscience and Remote Sensing2003，41，3： | 1 |
| 11 | Biosorption of cadmium by live and dead Spirulina:IR spectroscopic,kinetics and SEM studies显示文摘 | Doshi H Ray A Kothari I L | 2007 | Current Microbiology2007，54，3： | 1 |
| 12 | Enantiospecific Electrodeposition of a Chiral Catalyst 显示文摘 | Switzer J A Kothari H M Poizot P | 2003 | Nature (S0028-0836)2003，425，6957： | 1 |
| 13 | Crystal structure of prunin-1, a major component of the almond (Prunus dulcis) allergen amandin显示文摘 | ZHANG Yuzhu KOTHARY M H FU Tongjen | 2009 | Jourmal of Agricultural and Food Chemistry2009，57，1： | 1 |
| 14 | Purification and characterization of enterotoxigenic E1 Tor-like hemolysin produced by Vibrio fluvialis 显示文摘 | Kothary MH Lowman H McCardell BA | 2003 | Infect lmmun2003，71，6： | 1 |
| 15 | NoveI method for solving radial distribution networks显示文摘 | Das D Nagi H S Kothari D P | 1994 | IEEE Proceedings-Generation Transmission and Distribution1994，41，4： | 1 |
| 16 | Thermodynamic to kinetic transition in epitaxial electrodeposition显示文摘 | Switzer J A Kothari H M Bohannan E W | | J Phys Chem B0，106，16： | 1 |
| 17 | Hypokalemic periodic paralysis显示文摘 | Abbas H Kothari N Bogra J | 2012 | Natl J Maxillofae Surg2012，3，2： | 1 |
| 18 | Simultaneous determination of ator- vastatin calcium and olmesartan medoxomil in a pharmaceutical for- mulation by reversed phase high-performance liquid chromatography, high-performance thin-layer chromatography, and UV spectrophoto- metric methods显示文摘 | Soni H Kothari C Khatri D | 2014 | J AOAC lnt2014，97，3： | 1 |
| 19 | Effect of harmonic scalpel on seroma formation following surgery for breast cancer: a prospective randomized study显示文摘 | Kontos M Kothari A Hamed H | 2008 | J BUON2008，13，2： | 1 |
| 20 | Syntactic probabilities affect pronunciation variation in spontaneous speech 显示文摘 | Tily H Gahl S Arnon I Kothari A Snider N Bresnan J | 2009 | Language & Cognition2009，，1： | 1 |
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