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| 1 | Leptin levels in the differential diagnosis between benign and malignant ascites显示文摘AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites. | Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc Serdar Gergerlioglu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 2 | Therapeutic effect of caffeic acid phenethyl ester on cerulein-induced acute pancreatitis显示文摘AIM: To evaluate the therapeutic role of caffeic acid phenethyl ester (CAPE) in a rat model of ceruleaninduced acute pancreatitis (AP).METHODS: Seventy male Wistar albino rats were divided into seven groups. Acute edematous pancreatitis was induced by subcutaneous cerulein injection (20 μg/kg) four times at 1-h intervals. CAPE (30 mg/kg) was given by subcutaneous injection at the beginning (CAPE 1 group) and 12 h after the last cerulein injection (CAPE 2 group). Serum amylase, lipase, white blood cell count, and tumor necrosis factor (TNF)-α levels were measured, and pancreatic histopathology was assessed. RESULTS: In the AP group, amylase and lipase levels were found to be elevated and the histopathological evaluation showed massive edema and inflammation of the pancreas, with less fatty necrosis when compared with sham and control groups. Amylase and lipase levels and edema formation decreased signif icantly in the CAPE therapy groups (P < 0001); especially in the CAPE 2 group, edema was improved nearly completely (P = 0001). Inflammation and fatty necrosis were partially recovered by CAPE treatment. The pathologicalresults and amylase level in the placebo groups were similar to those in the AP group. White blood cell count and TNF-α concentration was nearly the same in the CAPE and placebo groups.CONCLUSION: CAPE may be useful agent in treatment of AP but more experimental and clinical studies are needed to support our observation of benef icial effects of CAPE before clinical usage of this agent. | Mehmet Buyukberber M Cemil Savas Cahit Bagci Mehmet Koruk Murat T Gulsen Ediz Tutar Tugba Bilgic Nurdan Ceylan | 2009 | World Journal of Gastroenterology2009，15，41： | 4 |
| 3 | Pretreatment with dexmedetomidine or thiopental decreases myoclonus after etomid- ate: a randomized, double - blind controlled trial 显示文摘 | MIZRAK A KORUK S BILGI M | 2010 | J Surg Res2010，159，1： | 1 |
| 4 | The Effects of Dexmedeto- midine on Ischemia Reperfusion Injury in Patients Undergoing Arthroscopy Under Spinal Anesthesia显示文摘 | Koruk S Mizrak A Kaya R | 2010 | J Med2010，42，： | 1 |
| 5 | Pretreatmentwithdexmedetomidine or thiopental decreases myoclonus after etomidate: a randomized, double-blind controlled trial显示文摘 | MizrakA KorukS BilgiM etal | 2010 | J Surg Res2010，159，1： | 1 |
| 6 | Pretreatmentwithdexmedetomi- dine or thiopental decreases myoclonus after etomidate: a random- ized, double- blind controlled trial显示文摘 | Mizrak A Koruk S Bilgi M | 2010 | J Surg Res2010，159，1： | 1 |
| 7 | Serum ubiquitin levels in patients with nonalcoholic steatohepatitis显示文摘 | Savas M C Koruk M Pirim I | 2003 | Hepatogastroenterology2003，50，51： | 1 |
| 8 | Serum level of acute phase proteins patients with nonalcoholic steatohepatitis显示文摘 | KORUK M TAYSI S SAVAS MC | 2003 | Turk J Gastroenterol2003，14，1： | 1 |
| 9 | Serum ubiquitin levels in patients with nonalcoholic steatohepatitis 显示文摘 | Savas MC Koruk M Pirim I | 2003 | Hepatogastroenterology2003，50，51： | 1 |
| 10 | Pretreatment with dexmedetomidine or thiopental decreases myoclonus after etomidate:A randomized,double-blind controlled trial显示文摘 | Mizrak A Koruk S Bilgi M | 2010 | J Surg Res2010，159，： | 1 |
| 11 | Serum thrombopoietin levelsin patiens with chronic hepatitis and liver cirrhosis,and itsrelationship with circulating thrombocyte counts显示文摘 | Koruk M Onuk MD Akcay F | 2002 | Hepatogastroenterology2002，49，48： | 1 |
| 12 | Demo- graphic and clinicopathological characteristics of nonal- coholic fatty liver disease in the East - Southeastern Anatolia regions in Turkey 显示文摘 | Bahcecioglu IH Koruk M Yilmaz O | 2006 | Med Princ Pract2006，15，1： | 1 |
| 13 | Evaluation of hepatic functions and biliary dynamics in patients with liver cirrhosis by quantitative scintigraphy 显示文摘 | Koruk M Ozkilic S Savas MC | 2003 | Hepatogastroenterology2003，50，54： | 1 |
| 14 | Bake hardening of laser welded dual phase steel 显示文摘 | Krizan D Waterschoot T Koruk A 1 el al | 2003 | Steel Research2003，74，10： | 1 |
| 15 | Intraoperative cholangioscopy with an ultrathin endoscope forhemobilia显示文摘 | M. Aydinli I. Koruk S. Koruk U. Aydin A. Kadayifci | 2011 | Endoscopy (S )2011，，02： | 1 |
| 16 | Comparative analysis of cerebrospinal fluid adenosine deaminase activity in meningitis显示文摘 | Karsen H Koruk ST Karahocagil MK | 2011 | Swiss Med Wkly2011，141，13： | 1 |
| 17 | Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis显示文摘 | Koruk M Taysi S Savas MC | 2004 | Acta Clin Lab Sci2004，34，： | 1 |
| 18 | Dexmedetomidine- ketamine and midazolam-ketamine combinations for sedation in pediatric patients undergoing extraeorporeal shock wave lithotripsy: a randomized prospective study显示文摘 | KORUK S MIZRAK A GUL R | 2010 | J Anesth2010，24，6： | 1 |
| 19 | Pretreatment with dexmedetomidine or thiopental decreases myoclonus after etomidate:a randomized,double-blind controlled trial显示文摘 | Mizrak A Koruk S Bilgi M | | 0，，01： | 1 |
| 20 | Oxidative stress and enzymatic antioxidant status in patients with nonalcoholic steatohepatitis显示文摘 | Koruk M Taysi S Savas MC | 2004 | Ann Clin Lab Sci2004，34，1： | 1 |
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