| 1 | Heme Oxygenase-1 May Play A Protective Role in Acetic Acid Induced Gastric Mucosa Damage by Decreasing iNOS Activity显示文摘Preliminary studies showed that the inducible form of heme exygenase-1 (HO-1) was induced and played a protective role in the process of inflammation. The present study aimed to investigate the possible role of HO-1 in acetic acid-induced gastric mucosa damage in rats. HO-1 mRNA and protein expressions were determined at 1 day, 3 days, and 7 days after ulceration by RT-PCR and western blotting, respectively. The severity of ulcer was assessed by ulcer area. Inducible nitric oxide synthase (iNOS) which are involved in oxidative injury were also measured. HO-1 gene expression in gastric mucosa was markedly increased after luminal application of an acetic acid solution. | ShenXZ KooMWL ChoCH | 2000 | 胃肠病学2000，5，B08： | 0 |
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