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| 1 | Combinatorial strategies for cancer eradication by silibinin and cytotoxic agents:efficacy and mechanisms显示文摘以开发增加治疗学的功效并且最小化化学疗法的代理人的全身的毒性的有效其他的策略,更多的努力与反癌症药在联合为他们的 synergistic 功效向饮食的补充和另外的 phytotherapeutic 代理人的调查正在被指导。一如此的代理人 issilibinin,它显示出有希望的 chemopreventive 和反癌症完成在在 vitro 并且在 vivo 研究各种各样。现在的评论在前列腺,胸,和肺癌症系统在生长抑制,房间周期规定,和 apoptosis 正式就职上总结 silibinin 和化学疗法的药的联合的效果。一起,当与这些药交上联合时,结果在生长抑制, chemoresistance 的颠倒, apoptosis 正式就职,和 G_2-M 检查点拘捕的猛烈增加上显示 synergistic 效果 ofsilibinin。这些结果关于联合化疗途径是高度重要的,在那里为联合的标准是反应不得不是 synergistic 并且这些药不应该分享抵抗的普通机制并且不在他们的主要副作用重叠。 | Komal RAINA Rajesh AGARWAI | 2007 | Acta Pharmacologica Sinica2007，28，9： | 5 |
| 2 | Silibinin and colorectal cancer chemoprevention:a comprehensive review on mechanisms and efficacy显示文摘Globally,the risk of colorectal cancer(CRC) as well as the incidence of mortality associated with CRC is increasing.Thus,it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents,for the prevention of CRC.The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC,and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy.Over the years,pre-clinical studies have shown that silibinin(a flavonolignan isolated from the seeds of milk thistle,Silybum marianum) has strong preventive and therapeutic efficacy against various epithelial cancers,including CRC.The focus of the present review is to provide a comprehensive tabular summary,categorically for an easy accessibility and referencing,pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression. | Komal Raina Sushil Kumar Deepanshi Dhar Rajesh Agarwal | 2016 | The Journal of Biomedical Research2016，30，6： | 2 |
| 3 | Target Identification of Grape Seed Extract in Colorectal Cancer Using Drug Affinity Responsive Target Stability (DARTS) Technique: Role of Endoplasmic Reticulum Stress Response Proteins显示文摘 | Molly M. Derry Ranganatha R. Somasagara Komal Raina Sushil Kumar Joe Gomez Manisha Patel Rajesh Agarwal Chapla Agarwal | 2014 | Current Cancer Drug Targets2014，，4： | 1 |
| 4 | Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells显示文摘 | Samiha Mateen Komal Raina Anil K Jain | 2012 | Epigenetics2012，7，10： | 1 |
| 5 | Procyanidin B2 3,3″-di-O-gallate, a Biologically Active Constituent of Grape Seed Extract, Induces Apoptosis in Human Prostate Cancer Cells Via Targeting NF-κB, Stat3, and AP1 Transcription Factors显示文摘 | Alpna Tyagi Komal Raina Suraj Prakash Shrestha Bettina Miller John A. Thompson Michael F. Wempe Rajesh Agarwal Chapla Agarwal | 2014 | Nutrition and Cancer2014，，4： | 1 |
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