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574篇 您的检索式：作者名="Kohn J"

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	题名	作者	年代	出处	被引量
1	Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9显示文摘RBPjk-dependent Notch signaling regulates both the onset of chondrocyte hypertrophy and the progression to terminal chondrocyte maturation during endochondral ossification. It has been suggested that Notch signaling can regulate Sox9 transcription, although how this occurs at the molecular level in chondrocytes and whether this transcriptional regulation mediates Notch control of chondrocyte hypertrophy and cartilage development is unknown or controversial. Here we have provided conclusive genetic evidence linking RBPjk-dependent Notch signaling to the regulation of Sox9 expression and chondrocyte hypertrophy by examining tissuespecific Rbpjk mutant(Prx1Cre;Rbpjkf/f), Rbpjk mutant/Sox9 haploinsufficient(Prx1Cre;Rbpjkf/f;Sox9f/1),and control embryos for alterations in SOX9 expression and chondrocyte hypertrophy during cartilage development. These studies demonstrate that Notch signaling regulates the onset of chondrocyte maturation in a SOX9-dependent manner, while Notch-mediated regulation of terminal chondrocyte maturation likely functions independently of SOX9. Furthermore, our in vitro molecular analyses of the Sox9 promoter and Notch-mediated regulation of Sox9 gene expression in chondrogenic cells identified the ability of Notch to induce Sox9 expression directly in the acute setting, but suppresses Sox9 transcription with prolonged Notch signaling that requires protein synthesis of secondary effectors.	Anat Kohn Timothy P Rutkowski Zhaoyang Liu Anthony J Mirando Michael J Zuscik Regis J O'Keefe Matthew J Hilton	2015	Bone Research2015，3，3：	8
2	Nontoxic block copolymer nanospheres: Design and characterization 显示文摘	Nardin C Bolikal D Kohn J	2004	Langmuir2004，20，11：	1
3	Phase Ⅲ study of weekly highdose infusional fluorouracil plus folinic acid with or without irinotecan in patients with metastatic colorectal cancer: European Organisation for Research and Treatment of Cancer Gastrointestinal Group study 40986 显示文摘	Kohne CH van Cutsem E Wils J	2005	J Clin Oncol2005，23，8：	1
4	Thyrocyles express a function- al toll - like receptor 3 : overexpression can be induced by viral in- fection and reversed by phenylmethimazole and is associated with Hashimoto autoimmune thyroiditis显示文摘	Harii N Lewis C J Kohn ID	2005	Mol Endocrinol2005，19，5：	1
5	Acoustic Emis- sion During Fatigue of Ti-6A1-4V: Incipient Fatigue Crack Detection Limits and Generalized Data Analy- sis Methodology 显示文摘	Kohn D H Dueheyne P Awerbuch J	1992	Journal of Materials Science1992，27，31：	1
6	Self-consistent equations including exchange and correlation effects 显示文摘	Kohn W Sham L J	1965	Phys Rev1965，140，：	1
7	Single agent lobapla- tin is active in patients with esophageal squamous cell carcinoma : a phase Ⅱ evaluation 显示文摘	Schmoll H J Kohne CH Papageorion E	1995	Proc ASCO1995，，14：	1
8	Pay satisfaction and organizational outcomes显示文摘	Currall S C Towler A J Judge T A Kohn L	2005	Personnel psychology2005，，58：	1
9	The influence of nonanatom- ical insertion and incongruence of meniscal transplants on the artic- ular cartilage in an ovine model 显示文摘	Van Lewinski G Kohn D Wirth C J etal	2008	Am J Sports Med2008，36，5：	1
10	Quantum density oscillations in an inhomogeneous electron gas显示文摘	KOHN W SHAM L J	1965	Phys Rev A1965，137，：	1
11	Guidelines for infection control indental health-care settings 2003显示文摘	KOHN W G COLLINS A S CLEVELAND J L	2003	Recommendations and Reports2003，53，17：	1
12	显示文摘	Kohn J Langer R	1984	American Chemical society1984，51，：	1
13	显示文摘	Kohn J	1993	Trends Polym SCi1993，1，7：	1
14	The relationship between trochlear dysplasia and medial patellofemoral ligament rupture location after patellar dislocation:an MRI evaluation显示文摘	Weber-Spickschen TS Spang J Kohn L	2011	Knee2011，18，：	1
15	The acrosomal protein Dickkopf-like 1(DKKL1)facilitates sperm penetration of the zona pellucida显示文摘	Kohn MJ Sztein J Yagi R		0，，05：	1
16	A new approach (cyano-transfer) for cyan- ogen bromide activation of Sepharose at neutral pH, which yields activated resins, free of interfering nitrogen derivatives 显示文摘	Kohn J M W	1982	Biochem Biophy Res Co1982，107，3：	1
17	Shaping the Australian crust over the last 300 million years:Insights from fission track thermotectonic and denudation studies of key terranes显示文摘	Kohn B P Gleadow A J W Brown R W	2002	Australian Journal of Earth Sciences2002，49，：	1
18	CAI inhibits the growth of small cell lung cancer cells显示文摘	Terry W Moody Jessica Chiles Elizabeth Moody Gregory J Sieczkiewicz Elise C Kohn	2003	Lung Cancer2003，，3：	1
19	Trace Element Zoning in Garnet as a Monitor of Crustal Melting显示文摘	SPEAR F S KOHN M J	1996	Geology1996，24，12：	1
20	A review of model applications for structured soils:Water flow and tracer transport显示文摘	KOHNE J M KOHNE S SIM/JNEK J	2009	Contaminant Hydrology2009，104，14：	1

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