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| 1 | 牡蛎壳体的同位素贝壳年轮研究显示文摘贝壳年轮学通过研究水生生物骨骼的周期性增长,来解译其生命历史及记录的环境信息。介绍了贝壳年轮研究的对象和方法、回顾了贝壳年轮的发展历程,并以渤海湾地区的现生和埋藏牡蛎壳体为例进行了贝壳年轮与壳体同位素剖面分析研究,首次同时关注牡蛎壳体剖面内的生长层和壳体韧带槽表面的特征层,二者共同指示了准确的生长年轮。结果显示,对应于壳体韧带槽表面凹沟的壳体剖面内灰色半透明生长层,具有一个年生长周期内最重的氧同位素比值,是晚秋至早春季节水温较低、食物来源匮乏时期形成的缓慢致密生长层;对应于壳体韧带槽表面外凸层中部的壳体剖面内灰色半透明生长层,具有较轻的氧同位素比值,是春季牡蛎产卵而形成的缓慢致密生长层;二者均具有良好的季节性指示意义,可以根据这些特征生长层对壳体的生长年龄进行准确的判断。 | 范昌福 王宏 裴艳东 Koeniger Paul 李延河 | 2010 | 地球科学进展2010，25，2： | 9 |
| 2 | How to use high-sensitivity cardiac troponins in acute cardiac care?显示文摘 | Kristian Thygesen Johannes Mair Evangelos Giannitsis Christian Mueller Bertil Lindahl Stefan Blankenberg Kurt Huber Mario Plebani Luigi M. Biasucci Marco Tubaro Paul Collinson Per Venge Yonathan Hasin Marcello Galvani Wolfgang Koenig Christian Hamm Joseph | 2012 | European Heart Journal2012，，18： | 1 |
| 3 | An easier method to remove migrated esophageal Z-stents显示文摘 | Paul Stephen Farkas Joshua David Farkas Kenneth Paul Koenigs | 1999 | Gastrointestinal Endoscopy1999，，2： | 1 |
| 4 | Mapping anterior temporal lobe language areas with fMRI: A multicenter normative study显示文摘 | Jeffrey R. Binder William L. Gross Jane B. Allendorfer Leonardo Bonilha Jessica Chapin Jonathan C. Edwards Thomas J. Grabowski John T. Langfitt David W. Loring Mark J. Lowe Katherine Koenig Paul S. Morgan Jeffrey G. Ojemann Christopher Rorden Jerzy P. Sza | 2010 | Neuroimage2010，，2： | 1 |
| 5 | Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial显示文摘 | Paul Emery Ferdinand C Breedveld Stephen Hall Patrick Durez David J Chang Deborah Robertson Amitabh Singh Ronald D Pedersen Andrew S Koenig Bruce Freundlich | 2008 | The Lancet2008，，9636： | 1 |
| 6 | How to use high-sensitivity cardiac troponins in acute cardiac care?显示文摘 | Kristian Thygesen Johannes Mair Evangelos Giannitsis Christian Mueller Bertil Lindahl Stefan Blankenberg Kurt Huber Mario Plebani Luigi M. Biasucci Marco Tubaro Paul Collinson Per Venge Yonathan Hasin Marcello Galvani Wolfgang Koenig Christian Hamm Joseph | 2012 | European Heart Journal2012，，18： | 1 |
| 7 | COMET研究结果并非最佳结论显示文摘Emery等进行的COMET研究表明,对于新发类风湿关节炎的多种结局指标,甲氨蝶呤联合依那西普优于单独使用甲氨蝶呤,然而,已知甲氩蝶呤单一疗法劣于缓解疾病的抗风湿药物(DMARD)联合治疗。因此,该试验设计使得研究结果对于循证风湿病学临床实践基本无用,循证风湿病学临床实践首先是应用常规DMARD联合治疗。 | Paul Emery Ferdinand Breedveld Andrew S Koenig Deborah Robertson 席莉(译) | 2009 | 世界临床医学2009，，9： | 0 |
| 8 | Direct imaging of shock wave splitting in diamond at Mbar pressure显示文摘Understanding the behavior of matter at extreme pressures of the order of a megabar(Mbar)is essential to gain insight into various physical phenomena at macroscales—the formation of planets,young stars,and the cores of super-Earths,and at microscales—damage to ceramic materials and high-pressure plastic transformation and phase transitions in solids.Under dynamic compression of solids up to Mbar pressures,even a solid with high strength exhibits plastic properties,causing the induced shock wave to split in two:an elastic precursor and a plastic shock wave.This phenomenon is described by theoretical models based on indirect measurements of material response.The advent of x-ray free-electron lasers(XFELs)has made it possible to use their ultrashort pulses for direct observations of the propagation of shock waves in solid materials by the method of phase-contrast radiography.However,there is still a lack of comprehensive data for verification of theoretical models of different solids.Here,we present the results of an experiment in which the evolution of the coupled elastic-plastic wave structure in diamond was directly observed and studied with submicrometer spatial resolution,using the unique capabilities of the x-ray free-electron laser(XFEL).The direct measurements allowed,for the first time,the fitting and validation of the 2D failure model for diamond in the range of several Mbar.Our experimental approach opens new possibilities for the direct verification and construction of equations of state of matter in the ultra-high-stress range,which are relevant to solving a variety of problems in high-energy-density physics. | Sergey Makarov Sergey Dyachkov Tatiana Pikuz Kento Katagiri Hirotaka Nakamura Vasily Zhakhovsky Nail Inogamov Victor Khokhlov Artem Martynenko Bruno Albertazzi Gabriel Rigon Paul Mabey Nicholas JHartley Yuichi Inubushi Kohei Miyanishi Keiichi Sueda Tadashi Togashi Makina Yabashi Toshinori Yabuuchi Takuo Okuchi Ryosuke Kodama Sergey Pikuz Michel Koenig Norimasa Ozaki | 2023 | Matter and Radiation at Extremes2023，8，6： | 0 |
| 9 | 瑞舒伐他汀治疗后c反应蛋白、LDL胆固醇及心血管事件率的降低:JUPITER试验的一项前瞻性研究显示文摘背景他汀类药物可降低高敏c反应蛋白(hsCRP)和胆固醇的浓度,而假设生成分析提示,若予以他汀类药物治疗后能使hsCRP浓度〈2mg/L同时LDL胆固醇浓度〈1.8mmol/L(〈7mg/L),则患者的临床结局可得到改善。然而,对他汀类药物治疗使LDL胆固醇和hsCRP同时降低的临床益处仍存有争议。该研究旨在前瞻性验证这一假设。方法在对JUPITER试验的15548例(占全部队列的87%)初始健康的个体进行的分析中,前瞻性评估瑞舒伐他汀20mg与安慰剂相对比的疗效。按治疗时LDL胆固醇浓度(〈1.8mmol/L、≥1.8mmol/L)和hsCRP浓度(〈2mg/L、〉/2mv2L)划分,以非致死性心肌梗死率、非致死性卒中率、因不稳定型心绞痛入院率、动脉血运重建率、心血管性死亡率(预设终点)为指标进行疗效评价。该研究最长随访时间为5年(M=1.9)。将随机分组后发生的所有事件均纳入。该试验在Clinical Trails.gov的注册编号为NCT00239681。结果与安慰剂组相比,瑞舒伐他汀治疗组中达到LDLJ胆固醇〈1.8mmol/L人群的血管事件减少了55%[事件发生率1.11/100(人·年)US0.51/100(人·年);HR0.45,95%C10.34~0.60,P〈0.0001],达到hsCRP〈2mg/L.h.群的血管事件减少了62%[事件发生率0.42/100(人·年);HR0.38,95%CI0.26~0.56,P〈0.0001]。虽然对于患者个体而言,LDL胆固醇与hsCRP的降低仅有微弱相关(r〈0.15),但研究发现,瑞舒伐他汀治疗组中同时达到LDL)胆固醇〈1.8mmol/L和hsCRP〈2mg/L人群的血管事件减少了65%[事件发生率0.38/100(人·年);校正HR0.35,95%CI0.23~0.54],而仅达到其中一项或两项均未达到的人群的血管事件仅减少了33%[事件发生率0.74/100(人·年);HR0.67,95%CI0.52~0.87](治疗组间P〈0.0001)。在达到LDL胆固醇〈1.8mmol/L和hsCRP〈1mg/L的人群中,血管事件减少了79%[事件发生率0.24/100(人·年);HR0.21,95%CI0.09~0.52]。无论选用何种脂质检测项目(包括载脂蛋白B/载脂蛋白AI比)作为终点,所达到的hsCRP浓度均为事件发生率的预测指标。结论对于选择开始进行药物预防的人群,LDL胆固醇和hsCRP浓度同时降低可作为瑞舒伐他汀治疗成功的指标。 | Paul M Ridker Eleanor Danielson Francisco A H Fonseca Jacques Genest Antonio M Gotto Jr John J P Kastelein Wolfgang Koenig Peter Libby Alberto J Lorenzatti Jean G MocFadyen Barge G Nordestgaard James Shepherd James T Willerson Robert J Glynn 徐斌(译) | 2009 | 世界临床医学2009，，10： | 0 |
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