| 3 | 特发性扩张型心肌病患者血清胆固醇水平的预后意义显示文摘Aims: Previous studies indicate that low cholesterol levels are associated with adverse prognosis in heart failure patients, because elevated lipoprotein levels may negate bacterial endotoxin load induced by gastrointestinal congestion. Methods and results: We examined the prognostic significance of lipid levels in a cohort of 422 patients with idiopathic dilated cardiomyopathy(iDCM) [50± 12 years, 342 males, 80 females, left ventricular ejection fraction(LV-EF): 31.6± 10.6% ]. During 42 months of follow-up, 86 patients(20.3% ) died or received a heart transplant. In univariate Cox regression analysis, reduced LV-EF, high New York Heart Association(NYHA) class, and increased LV end-diastolic diameter(LVEDD) were strong risk factors associated with that endpoint, whereas decreased total cholesterol, HDL-cholesterol, and apoprotein I levels were identified as weak risk predictors. After step-wise multivariable analysis, only LVEDD, NYHA class, and LV-EF emerged as parameters independently contributing to the model predicting risk for death or heart transplantation(P< 0.05). Cholesterol levels were positively associated with LV-EF and negatively associated with LVEDD(P< 0.05). Circulating sCD14 levels, a marker of endotoxin exposure, were related to cholesterol levels(P< 0.05) and LV-EF(P< 0.05). Conclusion: Decreased cholesterol levels do not independently predict adverse prognosis in patients with iDCM. Our findings indicate that low cholesterol levels are dependent on the severity of cardiac disease. | Christ M. Klima T. Grimm W. 杨海涛(译) 孙凯(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员