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| 1 | 妊娠期乳腺癌9例的诊断和综合治疗显示文摘目的 :研究妊娠期乳腺癌在诊断和手术、化疗、放疗综合治疗方面的特殊性。方法 :1992年 12月—1999年 6月 ,法国巴黎第十二大学附属HenriMondor医院放疗科收治 9例妊娠期乳腺癌患者 ,其中 3例诊断于妊娠期 ,6例诊断于分娩后 1年内。 5例行乳房保留治疗 ,4例改良根治术。所有病例行术后放疗。 7例接受化疗。结果 :9例钼靶摄片中 7例和所有的 5例超声检查提示肿瘤征象 ,诊断时总体病期晚 ,Ⅰ、Ⅱ、、Ⅲ期比例分别为11%、44 %和 44 %。中位随访 6 0月 (9— 89月 )时 ,6例无病生存 ,3例在治疗结束后 14月— 48月出现局部复发或远处转移。结论 :妊娠期乳腺癌诊断延误较为常见 ,对分娩后确诊的患者 ,应重视妊娠、哺乳期乳房体检和超声检查在鉴别诊断乳房肿块中的作用。治疗原则必须兼顾疾病的迫切性和胎儿的安全性。在可以及时开展化疗和放疗的综合治疗的前提下 。 | 陈佳艺 林原 Youlia KIROVA Franck FEUILLADE Jean-Paul Le BOURGEOIS | 2001 | 中国癌症杂志2001，11，5： | 21 |
| 2 | Recent advances in breast cancer radiotherapy:Evolution or revolution,or how to decrease cardiac toxicity?显示文摘Radiation therapy has a major role in the management of breast cancers.However,there is no consensus on how to irradiate and on volume definitions,and there are strong differences in strategies according to different centers and physicians.New treatment protocols and techniques have been used with the principal purpose of decreasing lung and heart toxicity and adapting radiation treatment to patients' anatomy.There is evidence that indicates internal mammary chain radiotherapy should be used carefully and that high quality techniques should be used for decreasing the dose delivered to the heart.This review of the literature presents the state of the art on breast cancer radiotherapy,with special focus on the indications,techniques,and potential toxicity. | Youlia M Kirova | 2010 | World Journal of Radiology2010，2，3： | 8 |
| 3 | Helical tomotherapy and volumetric modulated arc therapy:New therapeutic arms in the breast cancer radiotherapy显示文摘AIM To analyse clinical and dosimetric results of helical tomotherapy(HT) and volumetric modulated arc therapy(VMAT) in complex adjuvant breast and nodes irradiation.METHODS Seventy-three patients were included(31 HT and 42 VMAT). Dose were 63.8 Gy(HT) and 63.2 Gy(VMAT) in the tumour bed, 52.2 Gy in the breast, 50.4 Gy in supraclavicular nodes(SCN) and internal mammary chain(IMC) with HT and 52.2 Gy and 49.3 Gy in IMC and SCN with VMAT in 29 fractions. Margins to particle tracking velocimetry were greater in the VMAT cohort(7 mm vs 5 mm).RESULTS For the HT cohort, the coverage of clinical target volumes was as follows: Tumour bed: 99.4% ± 2.4%; breast: 98.4% ± 4.3%; SCN: 99.5% ± 1.2%; IMC:96.5% ± 13.9%. For the VMAT cohort, the coverage was as follows: Tumour bed: 99.7% ± 0.5%, breast: 99.3% ± 0.7%; SCN: 99.6% ± 1.4%; IMC: 99.3% ± 3%. For ipsilateral lung, Dmean and V20 were 13.6 ± 1.2 Gy, 21.1% ± 5%(HT) and 13.6 ± 1.4 Gy, 20.1% ± 3.2%(VMAT). Dmean and V30 of the heart were 7.4 ± 1.4 Gy, 1% ± 1%(HT) and 10.3 ± 4.2 Gy, 2.5% ± 3.9%(VMAT). For controlateral breast Dmean was 3.6 ± 0.2 Gy(HT) and 4.6 ± 0.9 Gy(VMAT). Acute skin toxicity grade 3 was 5% in the two cohorts.CONCLUSION HT and VMAT in complex adjuvant breast irradiation allow a good coverage of target volumes with an acceptable acute tolerance. A longer follow-up is needed to assess the impact of low doses to healthy tissues. | Olivier Lauche Youlia M Kirova Pascal Fenoglietto Emilie Costa Claire Lemanski Celine Bourgier Olivier Riou David Tiberi Francois Campana Alain Fourquet David Azria | 2016 | World Journal of Radiology2016，8，8： | 7 |
| 4 | Preliminary experience of helical tomotherapy for locally advanced pancreatic cancer显示文摘Radiotherapy for locally advanced pancreatic cancer is technically difficult and frequently associated with high-grade digestive toxicity.Helical tomotherapy(HT)is a new irradiation modality that combines megavoltage computed tomography imaging for patient positioning with intensity-modulated fan-beam radiotherapy.Its recent availability opens new fields of exploration for pancreatic radiotherapy as a result of its ability to tailor very well-defined dose distributions around the target volumes.Here,we report the use of HT in two patients with locally advanced pancreatic cancer. Doses to the bowel,kidneys and liver were reduced significantly,which allowed for excellent treatment tolerance without any high-grade adverse effects in either patient. | Cyrus Chargari Francois Campana Philippe Beuzeboc Sofia Zefkili Youlia M Kirova | 2009 | World Journal of Gastroenterology2009，15，35： | 5 |
| 5 | Could helical tomotherapy do whole brain radiotherapy and radiosurgery?显示文摘Whole brain radiotherapy (WBRT) remains the standard management of breast cancer patients with brain metastases, allowing for symptomatic improvement and good local control in most patients. However, its results remain suboptimal in terms of both efficacy and toxicity. In highly selected breast cancer patients, stereotaxic radiotherapy demonstrates a very good local control with a low toxicity. With the purpose of improving the efficacy/toxicity ratio, we report the association of integrated boost with WBRT in a breast cancer patient with brain metastases. Two and a half years after completion of helical tomotherapy (HT), the patient experienced clinical and radiological complete remission of her brain disease. No delayed toxicity occurred and the patient kept her hair without need of radiosurgical procedure. The HT provided a high dosimetric homogeneity, delivering integrated radiation boosts, and avoiding critical structures involved in long-term neurological toxicity. Further assessment is required and recruitment of breast cancer patients into clinical trials is encouraged. | Youlia M Kirova Cyrus Chargari Sofia Zefkili Franois Campana | 2010 | World Journal of Radiology2010，2，4： | 5 |
| 6 | 艾滋病病毒相关性原发性脑淋巴瘤的放疗疗效显示文摘目的:探讨艾滋病病毒相关性原发性脑淋巴瘤放射治疗的疗效。方法:从 1995年1月至 1999年 12月法国巴黎第十二大学Henri Mondor医院放疗科共收治艾滋病病毒相关性原发性脑淋巴瘤病人8例,均为男性,中位年龄为32岁(21~57岁)。8例病人均接受全脑照射30 Gy,后有4例缩野照射原发肿瘤 15~20 Gy,中位照射剂量为 37 .5 Gy。所有病人均未接受化疗。结果:放疗结束时,肿瘤缩小4例,肿瘤无变化 3例,肿瘤增大 1例;病人对急性放射反应耐受性尚好。病人中位生存期为7.1个月(3~19个月)。结论:艾滋病病毒相关性原发性脑淋巴瘤病人的预后差,而放射治疗可在一定程度上延长病人的生存期。 | 曹卡加 Luo DF Kirova Y Le Bourguois JP | 2001 | 癌症2001，20，6： | 3 |
| 7 | Genome-level analysis of genetic regulation of liver gene expression networks显示文摘 | Gatti, D Maki, A Chesler, EJ Kirova, R Kosyk, O Lu, L Williams, RW Perkins, A Langston, MA Threadgill, DW Rusyn, I | 2007 | 中国生物学文摘2007，21，11： | 3 |
| 8 | 转移性黑色素瘤的姑息性放疗显示文摘目的 :根据恶性黑色素瘤的放射生物学特性 ,设计了短疗程的放射治疗 ,以评价其在转移性患者中的姑息疗效。方法 :2 1例 (2 7个部位 )转移性恶性黑色素瘤接受姑息性放疗 ,照射部位包括骨转移 15个 ,淋巴结和皮下转移 7个 ,脑转移 5个。结合黑色素瘤生物特点和患者一般情况而制定时间 -剂量模式 ,主要包括 30Gy/10次 /2周 (10例 ,占 37% )和 2 0Gy/5次 /1.5周 (8例 ,占 30 % )。结果 :总的姑息有效率为 89% (2 4 /2 7) ,其中 ,骨和软组织转移的有效率为 90 % (2 0 /2 2 ) ,脑转移有效率为80 % (4/5 )。有效患者的中位缓解持续时间为 6 0d ,占剩余生存时间的 6 7%。结论 :短程放射治疗作为姑息治疗的手段 ,可以在大多数晚期转移性黑色素瘤患者中达到有效的减症作用。在高于常规分割剂量的基础上 ,可以视正常组织耐受性而适当降低分次剂量。总剂量的生物效应需达到相当于常规分割 36Gy以获得较满意的姑息疗效。 | 陈佳艺 Kirova YM 潘自强 Le Bourgeois JP | 2003 | 中国临床医学2003，10，4： | 2 |
| 9 | Concurrent use of aromatase inhibitors and hypofractionated radiation therapy显示文摘AIM: To retrospectively assess the acute and long-term toxicity using aromatase inhibitors (AI) therapy concurrently with hypofractionated radiotherapy (HFRT) in breast cancer patients. METHODS: From November 1999 to October 2007, 66 patients were treated with breast HFRT and concurrent AI. In 63 patients (95.5%), HFRT delivered a total dose of 32.5 Gy to the whole breast within 5 wk (five fractions, one fraction per week). Other fractionations were chosen in three patients for the patients' personal convenience. A subsequent boost to the tumor bed was delivered in 35 patients (53.0%). Acute toxicities were scored according to the Common Toxicity Criteria for Adverse Events v3. Late toxicity was defined as any toxicity occurring more than 6 mo after completion of HFRT and was scored according to the Late Effects Normal Tissue Task Force-Subjective, Objective, Management and Analytic scale. RESULTS: At the end of the HFRT course, 19 patients (28.8%) had no irradiation-related toxicity. Acute grade 1-2 epithelitis was observed in 46 patients (69.7%). One grade 3 toxicity (1.5%) was observed. With a median follow-up of 34 mo (range: 12-94 mo), 31 patients (47%) had no toxicity, and 35 patients (53%) presented with grade 1-2 fibrosis. No grade 3 or greater delayed toxicity was observed. CONCLUSION: We found that AI was well tolerated when given concurrently with HFRT. All toxicities were mild to moderate, and no treatment disruption was necessary. Further prospective assessment is warranted. | Cyrus Chargari Pablo Castro-Pena Ivan Toledano Marc A Bollet Alexia Savignoni Paul Cottu Fatima Laki Franois Campana Patricia De Cremoux Alain Fourquet Youlia M Kirova | 2012 | World Journal of Radiology2012，4，7： | 2 |
| 10 | Excitons, polar- ons, and bipolarons in conducting polymers显示文摘 | BRAZOVSKII S A KIROVA N N | 1981 | Soy Phys Jetp Lett1981，33，1： | 1 |
| 11 | Plastic sliding,strained and current conversion in density waves显示文摘 | Brazovskii S Kirova N | 1999 | Synthetic Metals1999，103，： | 1 |
| 12 | Anatomical, clinical and radiological delineation of target volumes in breast cancer radiotherapy planning:individual variabili- ty,questions and answers 显示文摘 | Castro Pena P Kirova YM Campana F | 2009 | Br J Radiol2009，82，979： | 1 |
| 13 | optical and electroopitcal absorption in conducting polymers显示文摘 | Kirova N Brazovskii S | 2002 | Thin Solid Film2002，403，： | 1 |
| 14 | Sensory aroma andtaste profiles of raw-dried sausages manufactured with a li-polytically active yeast culture 显示文摘 | Miteva E Kirova E Gadjeva D | 1986 | Nahrung1986，30，8： | 1 |
| 15 | Dislocations in charge density wave crystals 显示文摘 | Brazovskii S A Kirova N hi | 1981 | Soy Phys JETP1981，3348，： | 1 |
| 16 | Exergy analysis of industry ammonia plants显示文摘 | Ralev N Kirova Z | | 0，，01： | 1 |
| 17 | The acute skin and heart toxicity of a concurrent association of trastuzumab and locore- gional breast radiotherapy including internal mammary chain : a single-institution study显示文摘 | Canssa L Kirova YM Gault N | 2011 | Eur J Cancer2011，47，1： | 1 |
| 18 | Simplified rules for everyday delineation of lymph node areas for breast cancer radiotherapy显示文摘 | Kirova YM Castro Pena P Dendale R | 2010 | Br J Radiol2010，83，： | 1 |
| 19 | Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review显示文摘 | Kirova YM Vilcoq JR Asselain B | 2005 | 104(4) :856-8632005，104，4： | 1 |
| 20 | Electrical remodeling of cardiac myocytes from mice with heart failure due to the overexpression of tumor necrosis factor - alpha 显示文摘 | Petkova - Kirova PS Gursoy E Mehdi H | 2006 | Am J Physiol2006，290，5： | 1 |
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