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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Germanium waveguide photodetectors integrated on silicon with MBE显示文摘 | Oehme M Wemer J Kaschel M Kirfel O Kasper E | | 0，，01： | 1 |
| 3 | Germanium on silicon photodetectors with broad spectral range显示文摘 | Oehme M Kaschel M Wemer J Kirfel O Kasper E Schulze J | | 0，，02： | 1 |
| 4 | Interface formation during molecular beam epitaxial growth of neodymium oxide on silicon 显示文摘 | FISSEL A ELASSAR Z KIRFEL O | 2006 | J Appl Phys2006，99，07： | 1 |
| 5 | First in vitro and in vivo results of an anti-human CD133-antibody coated coronary stent in the porcine model显示文摘 | Alexander Sedaghat Jan-Malte Sinning Kathrin Paul Gregor Kirfel Georg Nickenig Nikos Werner | 2013 | Clinical Research in Cardiology2013，，6： | 1 |
| 6 | Cell migration:mechanisms of rear detachment and the formation of migration tracks显示文摘 | Kirfel G Rigort A Borm B | 2004 | Eur J Cell Biol2004，83，1112： | 1 |
| 7 | Cell migration: mechanisms of rear detachment and the formation of migration tracks 显示文摘 | Kirfel G Rigort A Bonn B | 2004 | Eur J Cell Biol2004，83，1112： | 1 |
| 8 | Neutron powder diffraction study of the thermal expansion of cuprite显示文摘 | SCH(A)FER W KIRFEL A | 2002 | Appl Phys A2002，74，： | 1 |
| 9 | Experimental charge density in polythionate anions: II. X-ray study of the electron density distribution in potassium tetrathionate, K2S4O6显示文摘 | P. C. Christidis P. J. Rentzeperis A. Kirfel G. Will | 1989 | Zeitschrift für Kristallographie . 1989 (1-2)1989，，： | 1 |
| 10 | Complete cytolysis and neonatal lethality in keratin 5 knockout mice reveal its fundamental role in skin integrity and in epidermolysis bullosa simplex显示文摘 | Peters B Kirfel J Bussow H | 2001 | Mol Biol Cell2001，12，： | 1 |
| 11 | Electron-density distribution in stishovite, SiO2: A new high-energy synchrotron-radiation study 显示文摘 | Kirfel A Krane H-G Blaha P Schwartz K Lippmann T | 2001 | Acta Cryst2001，57，： | 1 |
| 12 | Differential ligand- dependent protein-protein interactions between nuclear receptors and a neuronal-specific cofactor显示文摘 | Greiner EF Kirfel J Schule R | 2000 | Proc Nat Acad Scie USA2000，97，13： | 1 |
| 13 | Cell migration: mechanisms of rear detachment and the formation of migration tracks 显示文摘 | Kirfel G Rigort A Borm B | 2004 | Eur J Cell Biol2004，83，1112： | 1 |
| 14 | Mechanisms of rear detachment and the formation of migration tracks 显示文摘 | Kirfel G Riqort A Borm B | 2004 | Eur J Cell Biol2004，83，1112： | 1 |
| 15 | Charge density and chemical bo- nding in cubic boron nitride显示文摘 | WILL G KIRFEL A JOSTEN B | 1986 | Journal of the Less Common Metals1986，117，： | 1 |
| 16 | Keratins:a stuctural scaffold with emerging functions显示文摘 | Kirfel J Magin TM Reichelt J | 2003 | Cell Mol Life Sci2003，60，1： | 1 |
| 17 | Keratins:structural scaffold with emerging functions显示文摘 | KIRFEL J MARGIN TM REICHELT J | 2003 | Cell Mol Life Sci2003，60，1： | 1 |
| 18 | FHL2 expression in peritu- moural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer显示文摘 | Gullotti L Czerwitzki J Kirfel J | 2011 | Lab Invest2011，91，12： | 1 |
| 19 | Experimental charge density in polythionate anions显示文摘 | P. C. Christidis P. J. Rentzeperis A. Kirfel G. Will | 1985 | Zeitschrift für Kristallographie . 1985 (1-2)1985，，： | 1 |
| 20 | Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells显示文摘 | SCHULTE J H KIRFEL J LIM S | 2008 | Cancer Letters2008，271，1： | 1 |
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