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20篇 您的检索式:作者名="Kimm L"
    题名 作者 年代 出处 被引量
1难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) 2019英国医学杂志中文版2019,22,2:1
2Detection of VX contamination in soil through solid - phase microextraction sampling and gas chromatography/mass spectrometry of the VX degradation product bis (diisopropyl aminoethyl) disulfide显示文摘HOOK G L KIMM G KOCH D 2003Journal of Chromatography A2003,992,12:1
3Just whose quality of life is it anyway? Controversies and consistencies in measurements of qual- ity of liIe显示文摘Paul L Kimme L 2000Kidney Int2000,57,74:1
4Algorithms for the car sequencing and the level scheduling problem显示文摘Drexl A Kimms A Matthiessen L 2006Journal of Scheduling2006,9,2:1
5Otoacoustic emissionsand auditory brainstem responses in the newborn 显示文摘Kennedy CR Kimm L Dees DC 1991Arch DisChild1991,66,:1
6Effect ofenamel etching time on roughness and bond strength显示文摘Barkmeier W W Erickson R L Kimmes N S 2009Oper Dent2009,34,2:1
7Engineering DNA vaccine codelivery of co-stimulatory molecule genes显示文摘 Nottingham L K Wilson D M 1998Vaccine1998,16,:1
8Methodological factors involved in neonatal screening using evoked otoacoustic emissions and automated auditory brainstem response testing 显示文摘Thornton AR Kimm L Kennedy CR 2003Hear Res2003,182,:1
9Methodological factorsinvolved in neonatal screening using evoked otoacousticemis-sions and automated auditory brainstem response testing显示文摘Thornton AR Kimm L Kennedy CR 2003Hear Res2003,182,:1
10Self-perceived barriers to activity participation among sedentary adolescent girls显示文摘KIMM S GLYNN N W MCMAHON R P et a l 2006Med Sei Sports Exe2006,38,3:1
11Otoacoustic emissions and auditory brainstem responses in the newborn显示文摘Kennedy CR Kimm L Dees DC 1991Arch Dis Child1991,66,:1
12Otoacoustic emissions and auditory brainstem responses in the newborn显示文摘Kennedy CR Kimm L Dees DC 0,,66:1
13External-and middle -ear factors affecting evokedotoacoustic emissions in neonates显示文摘3,Thornton ARD Kimm L Kennedy CR 1993British Journal Audiology1993,27,:1
14Traffic flooding allack detection wilh Snmp Mib uskag Svm 显示文摘Yu J L I KimM S etal 2008Comput Commtm2008,31,17:1
15Estimating corn leaf chlorophyll concentration from leaf and canopy reflectance 显示文摘Daughtry C S T Walthall C L KimM S 2000Remote Sensng of Enviornment2000,74,:1
16Bond strength of self-etch adhesives to pre-etched enamel显示文摘ERICKSON R L BARKMEIER W W KIMMES N S 2009Dent Mater2009,25,10:1
17Feasibility of Otoacoustic emission detection followed by ABR as a universal neonatal screening test for hearing impairment显示文摘 Kimm L Cafarelli Dees D 1994Br J Audiol1994,28,:1
18Algorithms for the car sequencing and the level scheduling problem 显示文摘DREXL A KIMMS A MATTHIESSEN L 2006Journal of Scheduling2006,9,2:1
19External- and middle- ear factors affecting evoked otoacoustic emissions in neonates显示文摘Thornton ARD Kimm L Kennedy CR 1993Br J Audiol1993,27,:1
20转变观念 类风湿关节炎疑似患者应及早转诊至风湿专科显示文摘临床问题 类冈湿关节炎可以影响1%的成年人,并与进展性关节损害、致残以及死亡率增高相关。用缓解疾病的抗风湿性药物(DMARDs)治疗,如甲氨蝶呤,可以减慢关节损害的进程,从而改善长期残疾,这从影像学上已得到证实。因此,改变传统的做法,尽可能早地开始DMARD治疗便应运而生。指南建议患者应尽早就诊,Kimme L Hyrich 李君(译) 2008英国医学杂志中文版2008,11,3:0
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