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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Differential feed- back in codehook-based multiuser MIMO systems in slowly varying channels 显示文摘 | KIM K KIM T LOVE D J etal | 2012 | IEEE Transactions on Communications2012，60，2： | 1 |
| 3 | MIMO systems with limited rate differential feedback in slowly var- ying channets显示文摘 | KIM T LOVE D J CLERCKX | 2011 | IEEE Transactions on Communica- tions2011，59，4： | 1 |
| 4 | Association of health lit-eracy with self-management behavior in patients with diabetes显示文摘 | kim S Love F Quistberg DA | 2004 | Diabetes Care2004，2712，： | 1 |
| 5 | Inactivation of MS2 coliphage by ferrous ion and zero-valent iron nanoparticles 显示文摘 | Kim JY Lee C Love DC | 2011 | Environ Sci Technol2011，45，： | 1 |
| 6 | A conceptual framework fur integrating building information modeling with augmented reality 显示文摘 | Wang X Love P E D Kim M J | 2013 | Automation in Construction2013，，34： | 1 |
| 7 | Association of health literacy with self-management behavior in patients with diabetes显示文摘 | Kim S Love F Quistberg DA | 2004 | Diabetes Care2004，27，12： | 1 |
| 8 | Association of health literacy with self-management behavior in patients with diabetes 显示文摘 | Kim S Love F Quistbeg DA | 2004 | Diabetes Care2004，27，12： | 1 |
| 9 | Inactivation of MS2coliphage by ferrous ion and zero-valent iron nanoparticles显示文摘 | Kim J Y Lee C Love D C | 2011 | Environmental Science&Technology2011，45，16： | 1 |
| 10 | Association of health literacy with self management behavior in patients with diabetes 显示文摘 | Kim S Love F Quistberg A | 2004 | Diabetes Care2004，27，12： | 1 |
| 11 | Association of health literacy with self--management behavior in patients with di- abetes显示文摘 | Kim S Love F Quistberg DA | 2004 | Diabetes Care2004，27，12： | 1 |
| 12 | Nod1/Nod2 mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure显示文摘 | Loving C L Osorio M Kim Y G | 2009 | Infect Immun2009，77，10： | 1 |
| 13 | Inactivation of MS2 coliphage by ferrous ion and zero-valent iron nanoparticles 显示文摘 | Kim J Y Lee C Love D C | 2011 | Environmental Science & Technology2011，45，16： | 1 |
| 14 | Inactivation of MS2 coliphage by ferrous ion and zero-valent iron nanoparticles 显示文摘 | Kim J Y Lee C Love D C | 2011 | Environmental Science and Technology2011，45，16： | 1 |
| 15 | Limited feedback beamforming sys-tems for dual-polarized MIMO channel 显示文摘 | Kim T Clerckx B Love D J | 2010 | IEEE Transactions on Wireless Communications2010，11，9： | 1 |
| 16 | Disruption Management for an Airline-Rescheduling of Aircraft显示文摘 | Jesper Larsen Michael Love Kim Riis Sorensen | 2002 | Applications of Evolutionary Computing2002，2279，3： | 1 |
| 17 | Nodl/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure 显示文摘 | Loving CL Osorio M Kim YG | 2009 | Infect Imm2009，77，10： | 1 |
| 18 | Millimeter wave beamforming for wireless backhaul and access in small cell networks显示文摘 | HUR S KIM T LOVE D J | 2013 | IEEE Transactions on Communications2013，61，10： | 1 |
| 19 | Millimeter wave beamforming for wireless baekhaul and access in small cell networks显示文摘 | Hur S Kim T Love D | 2013 | IEEE Transactions on Communications2013，61，10： | 1 |
| 20 | Association of health literacy with self-management behavior in patients with diabetes 显示文摘 | Kim S Love F Quistberg DA | 2004 | Diabetes Care2004，27，12： | 1 |
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