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| 1 | Treatment outcomes for multidrug-resistant tuberculosis under DOTS-Plus:a systematic review and meta-analysis of published studies显示文摘Background:Anti-tuberculosis drug resistance is a major public health problem that threatens the progress made in tuberculosis care and control worldwide.Treatment success rates of multidrug-resistant tuberculosis(MDR-TB)is a key issue that cannot be ignored.There is a paucity of evidence that assessed studies on the treatment of MDR-TB,which focus on the effectiveness of the directly observed treatment,short-course(DOTS)-Plus program.Therefore,it is crucial to assess and summarize the overall treatment outcomes for MDR-TB patients enrolled in the DOTS-Plus program in recent years.The purpose of this study was to thus assess and summarize the available evidence for MDR-TB treatment outcomes under DOTS-Plus.Methods:A systematic review and meta-analysis of published literature was conducted.Original studies were identified using the databases MEDLINE®/PubMed®,Hinari,and Google Scholar.Heterogeneity across studies was assessed using the Cochran’s Q test and I2 statistic.Pooled estimates of treatment outcomes were computed using the random effect model.Results:Based on the 14 observational studies included in the meta-analysis,it was determined that 5047 patients reported treatment outcomes.Of these,the pooled prevalence,63.5%(95%CI:58.4-68.5%)successfully completed full treatment(cured or treatment completed)with a pooled cure rate of 55.6%,whereas 12.6%(95%CI:9.0-16.2%)of the patients died,14.2%(95%CI:11.6-16.8%)defaulted from therapy,and 7.6%(95%CI:5.6-9.7%)failed therapy.Overall 35.4%(95%CI:30-40.8%)of patients had unsuccessful treatment outcomes.An unsatisfactorily high percentage 43%(95%CI:32-54%)of unsuccessful treatment outcomes was observed among patients who were enrolled in standardized treatment regimens.Conclusion:This study revealed that patients with MDR-TB exhibited a very low treatment success rate compared to the World Health Organization 2015 target of at least 75 to 90%.The high default rate observed by conducting this literature review could possibly explain the spread of the MDR-TB strain in various populations.A better treatment success rate was observed among patients in individualized treatment regimens than in standardized ones.Conducting further individual-based meta-analysis is recommended to identify potential factors for defaulting treatment using large-scale and multi-center studies. | Kelemu Tilahun Kibret Yonatan Moges Peter Memiah Sibhatu Biadgilign | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | A survey on intrabody communications for body area network applications 显示文摘 | Seyedi M Kibret B Lai DTH | 2013 | IEEE Trans Biomed Eng2013，60，8： | 1 |
| 3 | Characterization of a phenol degrading mixed population by enzyme assay显示文摘 | Kibret M Somitsch W Robra K H | | 0，，04： | 1 |
| 4 | Investigation of galvanic- coupled intrabody communication using the human body circuit model 显示文摘 | Kibret B Seyedi M Lai DTH | 2014 | IEEE J Biomed Health2014，18，4： | 1 |
| 5 | A Survey on Intrabody Communications for Body Area Network Applications显示文摘 | Seyedi M Kibret B Lai D T H | 2013 | IEEE Transactions on Biomedical Engineering2013，，8： | 1 |
| 6 | Characterization of a phenol degrading mixed population by enzyme assay显示文摘 | KIBRET M SOMITSCH W ROBRA K H | 2000 | Water Res2000，34，4： | 1 |
| 7 | Characterization of a enol degrad- ing mixed population by enzyme assay显示文摘 | KIBRET M SOMITSEH W ROBRAK H | 2000 | Water Res2000，34，4： | 1 |
| 8 | Prosthetic aortic heart valves:Modeling and design显示文摘 | Hadi M Kibret M | 2011 | Medical Engineering and Physics2011，33，2： | 1 |
| 9 | The Sanitary Conditions of Food Service Establishments and Food Safety Knowledge and Practices of Food Handlers in Bahirdar Town显示文摘 | Mulugeta Kibret Bayeh Abera | | 0，，01： | 1 |
| 10 | A survey on intrabody communications for body area network applications显示文摘 | SEYEDI M KIBRET B LAI D T H | 2013 | IEEE Transactions on Biomedical Engineering2013，60，8： | 1 |
| 11 | Characterization of a phenol degrading mixed population by enzyme assay 显示文摘 | Kibret M Somitsch W Robra K H | 2000 | Water Reaserch2000，34，4： | 1 |
| 12 | Characterization of a phenol degrading mixed population by enzyme assay显示文摘 | KIBRET M SOMITSCH W ROBRA K H | 2000 | Water Res2000，34，4： | 1 |
| 13 | A survey on intrabody communications for body area network applications 显示文摘 | Seyedi M Kibret B Lai DTH | 2013 | IEEE Trans Biomed Eng2013，60，8： | 1 |
| 14 | A survey on intrabody communications for body area network applications显示文摘 | Seyedi Kibret Lai | 2013 | lEEE Transactions on Biomedical Engineering2013，60，8： | 1 |
| 15 | Prevalence and antibiogram of bacterial isolates from urinary tract infections at Dessie Health Research Laboratory,Ethiopia显示文摘Objective:To determine the prevalence and antimicrobial susceptibility of bacteria from suspected urinary tract infections.Methods:A retrospective analysis of Imcterial pathogens and their antimicrobial susceptibility was done on urine samples at Dessic Regional Laboratory in the period 2003 to 2010.Antimicrobial susceptibility tests were done using disc diffusion technique as per the standard of Kirby-Bauer method.Results:The male to female ratio of the patients was 1:1.96.Of the total 1404 samples..119(22.7%,were culture positive.Escherirhia coli was the dominant isolate(63.6%) followed by Klebsiella spp.(8.5%) and Proteus spp.(8.2%).The overall resistance rates to erythromycin,amoxycillin,and tetracycline were 85.6%,88.9%and 76.7%,respectively,The three most frequently isolated bacteria had resistance rates of 80.1%-90.0%to.amoxycillin,and tetracycline and sensitivity rates of 0to 25%to nitrofurantoin,ciprofloxacin and genlamiein.Antibiogram of isolates showed that 152i47.85%isolates were resistance to two and more antimicrobials.Conclusions:In the study area resistance rates to erythromycin,amoxycillin and tetracycline were high.Since most isolates were sensitive to nitrofurantoin and gentamicin.they are considered as appropriate antimicrobials for empirical treatment urinary tract infections. | Mulugeta Kibret Bayeh Abera | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，2： | 1 |
| 16 | Prosthetic Aortic Heart Valves:Modeling and Design显示文摘 | HADI M KIBRET M | 2011 | Medical Engineering and Physics2011，33，2： | 1 |
| 17 | Avidity of onconeural antibodies is of clinical relevance显示文摘 | Cecilie Totland Ming Ying Mette Haugen Kibret Mazengia Anette Storstein Jan Aarseth Aurora Martinez Christian Vedeler | 2013 | Cancer Immunology Immunotherapy2013，，8： | 1 |
| 18 | Mechanisms and applications of plant growth promoting rhizobacteria:Current perspective显示文摘 | AHEMAD M KIBRET M | 2014 | Journal of King Saud University-Science2014，26，1： | 1 |
| 19 | Mechanisms and applications of plantgrowth promoting rhizobacteria: Current perspective显示文摘 | AHEMAD M KIBRET M | 2014 | Journal ofKing Saud University-Science2014，26，1： | 1 |
| 20 | Design and Implementation of Network Management Based-on SNMP显示文摘 | Wu Tao Mamo Tigist Kibret Zhao Hai-bao | 2010 | 中国电子商情(通信市场)2010，，2： | 0 |
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