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| 1 | Nucleus-targeted Dmp1 transgene fails to rescue dental defects in Dmp1 null mice显示文摘Dentin matrix protein 1(DMP1) is essential to odontogenesis. Its mutations in human subjects lead to dental problems such as dental deformities, hypomineralization and periodontal impairment. Primarily, DMP1 is considered as an extracellular matrix protein that promotes hydroxyapatite formation and activates intracellular signaling pathway via interacting with avb3 integrin. Recent in vitro studies suggested that DMP1 might also act as a transcription factor. In this study, we examined whether full-length DMP1 could function as a transcription factor in the nucleus and regulate odontogenesis in vivo. We first demonstrated that a patient with the DMP1M1 V mutation, which presumably causes a loss of the secretory DMP1 but does not affect the nuclear translocation of DMP1, shows a typical rachitic tooth defect. Furthermore, we generated transgenic mice expressingNLSDMP1, in which the endoplasmic reticulum(ER) entry signal sequence of DMP1 was replaced by a nuclear localization signal(NLS) sequence, under the control of a 3.6 kb rat type I collagen promoter plus a 1.6 kb intron 1. We then crossbred theNLSDMP1 transgenic mice with Dmp1 null mice to express the NLSDMP1 in Dmp1-deficient genetic background. Although immunohistochemistry demonstrated thatNLSDMP1 was localized in the nuclei of the preodontoblasts and odontoblasts, the histological, morphological and biochemical analyses showed that it failed to rescue the dental and periodontal defects as well as the delayed tooth eruption in Dmp1 null mice. These data suggest that the full-length DMP1 plays no apparent role in the nucleus during odontogenesis. | Shu-Xian Lin Qi Zhang Hua Zhang Kevin Yan Leanne Ward Yong-Bo Lu Jian-Quan Feng | 2014 | International Journal of Oral Science2014，6，3： | 2 |
| 2 | Rereading urban regimen theory: a sympathetic critique 显示文摘 | Kevin Ward | 1996 | Geoforum1996，27，4： | 1 |
| 3 | Identification of miRNA Changes in Alzheimer’s Disease Brain andCSF Yields Putative Biomarkers and Insights into Disease Pathways显示文摘 | John P. Cogswell James Ward Ian A. Taylor Michelle Waters Yunling Shi Brian Cannon Kevin Kelnar Jon Kemppainen David Brown Caifu Chen Rab K. Prinjha Jill C. Richardson Ann M. Saunders Allen D. Roses Cynthia A. Richards | 2008 | Journal of Alzheimer’s Disease2008，，1： | 1 |
| 4 | Characterization of the intestinal microbiota of two Antarctic notothenioid fish species显示文摘 | Naomi L. Ward Blaire Steven Kevin Penn Barbara A. Methé William H. Detrich | 2009 | Extremophiles2009，，4： | 1 |
| 5 | The engi- neering aspects of automated prepreg layup: History, present and future 显示文摘 | Lukaszewicz D J Ward Carwyn Potter Kevin D | 2012 | Composites : Part B2012，43，3： | 1 |
| 6 | The effect of vitamin E on blood pressure in individuals with type 2 diabetes: a randomized, double-blind, placebo-controlled trial显示文摘 | Natalie C Ward Jason HY Wu Michael W Clarke Ian B Puddey Valerie Burke Kevin D Croft Jonathan M Hodgson | 2007 | Journal of Hypertension2007，，1： | 1 |
| 7 | Dilemmas in the management of temporary work agency staff 显示文摘 | Kevin Ward Damian Grimshaw Jill Rubery Huw Beynon | 2001 | Human Resource Management Journal2001，11，4： | 1 |
| 8 | An Empirical Investigation of a Biopsychosocial Model of Pain in Multiple Sclerosis显示文摘 | Melissa A. Day Dawn M. Ehde L. Charles Ward Narineh Hartoonian Kevin N. Alschuler Aaron P. Turner George H. Kraft Mark P. Jensen | 2016 | The Clinical Journal of Pain2016，，2： | 1 |
| 9 | Urban Political Economy,'New Urban Politics' and the Media Insights and Limits显示文摘 | Kevin Ward | | 0，，01： | 1 |
| 10 | Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle显示文摘 | Natalie C Ward Jonathan M Hodgson Ian B Puddey Trevor A Mori Lawrence J Beilin Kevin D Croft | 2003 | Free Radical Biology and Medicine2003，，2： | 1 |
| 11 | Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results Data, 1973 to 2009显示文摘 | Benjamin Ansa Michael Goodman Kevin Ward Scott A. Kono Taofeek K. Owonikoko Kristin Higgins Jonathan J. Beitler William Grist Trad Wadsworth Mark El‐Deiry Amy Y. Chen Fadlo Raja Khuri Dong M. Shin Nabil F. Saba | 2013 | Cancer2013，，14： | 1 |
| 12 | Constructing markets for temporary labor: Employment liberalization and the internationalization of the staffing industry显示文摘 | Jamie Peck Nik Theodore and Kevin Ward | 2005 | Global Networks2005，5，1： | 1 |
| 13 | Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer’s Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study显示文摘 | Noel G. Faux Kathryn A. Ellis Lorine Porter Chris J. Fowler Simon M. Laws Ralph N. Martins Kelly K. Pertile Alan Rembach Chris C. Rowe Rebecca L. Rumble Cassandra Szoeke Kevin Taddei Tania Taddei Brett O. Trounson Victor L. Villemagne Vanessa Ward David A | 2011 | Journal of Alzheimer’s Disease2011，，4： | 1 |
| 14 | ELEVATED HIGH-MOBILITY GROUP BOX 1 LEVELS IN PATIENTS WITH CEREBRAL AND MYOCARDIAL ISCHEMIA显示文摘 | Richard S. Goldstein Margot Gallowitsch-Puerta LiHong Yang Mauricio Rosas-Ballina Jared M. Huston Christopher J. Czura David C. Lee Mae F. Ward Annette N. Bruchfeld Haichao Wang Martin L. Lesser Adam L. Church Adam H. Litroff Andrew E. Sama Kevin J. Trace | 2006 | Shock2006，，6： | 1 |
| 15 | Hospital Readmission Is Associated With Poor Survival After Esophagectomy for Esophageal Cancer显示文摘 | Felix G. Fernandez Onkar Khullar Seth D. Force Renjian Jiang Allan Pickens David Howard Kevin Ward Theresa Gillespie | 2014 | The Annals of Thoracic Surgery2014，，： | 1 |
| 16 | Synthesis,characterization,and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugate显示文摘 | Kevin J Landmark Stassi DiMaggio Jesse Ward | 2008 | Dendrimers ACS Nano2008，2，4： | 1 |
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