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| 1 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 2 | Expanding the functional role of long noncoding RNAs显示文摘 | Per Johnsson Kevin V Morris | 2014 | Cell Research2014，24，11： | 5 |
| 3 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 4 | Birth characteristics and risk of neuroblastoma in young children显示文摘 | Kevin Y Julie V | | 0，，5： | 1 |
| 5 | Supplier risk assessment and monitoring for the automotive industry显示文摘 | Jennifer V Blackhurst Kevin P Scheibe Danny J Johnson | 2008 | International Journal of Physical Distribution & Logistics Management2008，38，2： | 1 |
| 6 | Transgenic pigs as bioreactors: a comparison ofgamma-carboxylation of glutamic acid in recombinant humanprotein C and factor Ⅸ by the mammary gland显示文摘 | KEVIN E V C STEPHEN P B CHRISTOPHER G R | 1999 | Genetic Analysis: Biomolecular Engineering1999，15，： | 1 |
| 7 | Origin and seed phenotype of maize low phytic acid 1-1 and low phytic acid 2-1显示文摘 | Paola F Gerbasi Kevin A Young | 2000 | Plant Physiol2000，124，： | 1 |
| 8 | Biosensors employing ionic self-assembled multilayers adsorbed on long- period fiber gratings显示文摘 | Wang Z Y Heflin J R Kevin V C | 2009 | Sensors and Actuators B:Ohemical2009，139，2： | 1 |
| 9 | Characterization of isomeric sulfonamides using capilary zone exlectrophoresis coupled with nano-electrospray quasi-MS-MS-MS显示文摘 | Kevin P B Steven J L Dietrich A V | 1997 | J Mass Spectrom1997，，32： | 1 |
| 10 | Birth characteristics and risk of neuroblastoma in young children 显示文摘 | Kevin Y Julie V | 2007 | Am J Epidemio12007，165，5： | 1 |
| 11 | Birth characteristics and risk of neuroblastoma in young children 显示文摘 | Kevin Y Julie V | 2007 | Am J Epidemiol2007，165，5： | 1 |
| 12 | Investigating the role of natural phyto-oestrogens on bone health in postmenopausal women显示文摘 | Silvia V Kevin C Simon PR | 2003 | British Journal of nutrition2003，89，1： | 1 |
| 13 | Investigation of Path De- pendence in Commercial Lithium-ion Cells Chosen for Pulg-in Hy- bird Vehicle Duty Cycle Protocols 显示文摘 | Geing Kevin L Sazhin Serfiy V | 2011 | Journal of Power Source2011，196，： | 1 |
| 14 | Tobacco protein separation 1 aqueous two - phase extraction 显示文摘 | Deepa B Carol W Kevin V C | 2003 | Joural of Chromatography A2003，989，： | 1 |
| 15 | Neuromuscular Training Techniques to Target Deficits Before Return to Sport After Anterior Cruciate Ligament Reconstruction显示文摘 | Gregory D Myer Mark V Paterno Kevin R Ford Timothy E Hewett | 2008 | Journal of Strength and Conditioning Research2008，，3： | 1 |
| 16 | Noninvasive measurements of actively-induced change in muscle metabolism显示文摘 | KEVIN K M HITROOMI K KRISTA V | 1995 | J Bio1995，24，： | 1 |
| 17 | Synchronization of Lorenz- Based Chaotic Circuits withApplications to Communications显示文摘 | Kevin M Cuomo Alan V Oppenheim Steven H Strogatz | 1993 | IEEE Trans1993，40，： | 1 |
| 18 | The economics of copyright' fair use' in a networked world显示文摘 | KLEIN BENJAMIN ANDRES V LERNER KEVIN M MURPHY | 2002 | Ameri- can Economic Review2002，1，： | 1 |
| 19 | SMOTE : Synthetic Minor- ity Over-sampling technique显示文摘 | Nitesh V Kevin W Lawrence O | 2002 | Journal of Artificial Intelligence Research2002，12，6： | 1 |
| 20 | Processing,fracture toughness and vickers hardness of allylhydridopolycarbosilane-derived silicon carbide显示文摘 | MORAES KEVIN V INTERRANTE LEONARD V | 2003 | J Am Ceram Soc2003，86，2： | 1 |
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