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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Delayed ad- ministration of antibiotics and atypical presentation in community-acquired pneumonia 显示文摘 | Waterer GW Kessler LA Wunderink RG | 2006 | Chest2006，130，： | 1 |
| 3 | Comparative epidemiology of dependence on tobacco,alcohol,controlled substances,and inhalants:basic findings from the national co-morbidity survey显示文摘 | Anthony JC Warner LA Kessler RC | 1994 | Exp Clin Psychopharmacol1994，2，： | 1 |
| 4 | Sacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction:Systematic Review and Meta-analysis显示文摘 | Kessler TM La Framboise D Trella S | 2010 | Eur Urnl2010，58，6： | 1 |
| 5 | Sacral Neuromodulafion for Neurogenic Lower Urinary Tract Dysfunction: Systematic Review and Meta-analysis 显示文摘 | Kessler TM La Framboise D Trelle S | 2010 | Eur Urol2010，58，6： | 1 |
| 6 | Sacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction: Systematic Review and Meta-analysis显示文摘 | Thomas M. Kessler David La Framboise Sven Trelle Clare J. Fowler Gustav Kiss Jürgen Pannek Brigitte Schurch Karl-Dietrich Sievert Daniel S. Engeler | 2010 | European Urology2010，，6： | 1 |
| 7 | Delayed administration of antibiotics and atypical presentation in community-acquired pneumonia显示文摘 | Waterer GW Kessler LA Wunderink RG | | 0，，： | 1 |
| 8 | Sacral neuromodu- lation for neurogenie lower urinary tract dysfunction: systematic review and meta-analysis 显示文摘 | Kessler TM La Framboise D Trelle S | 2010 | Eur Urol2010，58，： | 1 |
| 9 | Regulation of interleukin (IL)-1a,IL-1b and IL-6 expression by growth hormone and prolactin in bovine thymic stromal cells显示文摘 | Tseng YH Kessler MA Schuler LA | 1997 | Mol Cell Endocrinol1997，128，12： | 1 |
| 10 | Lifetime co-oc- currence of DSM-II -R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey 显示文摘 | Kessler RC Crum RM Warner LA | 1997 | Arch Gen Psychiatry1997，54，4： | 1 |
| 11 | Sacral neuro-modulation for neurogenic lower urinary tract dysfunction : sys-tematic review and Meta-analysis 显示文摘 | Kessler TM La Framboise D Trelle S | 2010 | Eur Urol2010，58，6： | 1 |
| 12 | Syndrome of the cervical plexus caused by high cervical nerve root,compression显示文摘 | Kessler LA Abla A | 1991 | Neurosurgery1991，28，4： | 1 |
| 13 | Sacral neuromodulation for neurogenic lower urinary tract dysfunction:systematic review and meta-analysis显示文摘 | Kessler T M La Framboise D Trelle S | 2010 | Eur Urol2010，58，6： | 1 |
| 14 | Prevalence and correlates of drug use and dependence in the United States : results from the National Comorbidity Survey显示文摘 | Warner LA Kessler RC Hughes M | 1995 | Arch Gen Psychiatry1995，52，3： | 1 |
| 15 | Delayed adminis- tration of antibiotics and atypical presentation in community- acquired pneumonia 显示文摘 | Waterer GW Kessler LA Wunderink RG | 2006 | Chest2006，130，1： | 1 |
| 16 | Sacral neuromodulation for neurogenic lower urinary tract dysfunction:systematic review and meta-analysis显示文摘 | Kessler TM La Framboise D Trelle S | 2010 | Eur Urol2010，58，6： | 1 |
| 17 | Sonographic as- sessment of volar digital nerve injury in the context of pene- trating trauma 显示文摘 | Umans H Kessler J de la Lama M | 2010 | Am J Roentgenol2010，194，5： | 1 |
| 18 | Sacral Neu- romodulation for Neurogenic Lower Urinary Tract Dys- function: Systematic Review and Meta--analysis显示文摘 | Kessler TM La Framboise D Trolle S | 2010 | Eur Urol2010，58，6： | 1 |
| 19 | Adverse effects associated with use of nevirapine in HIVpostexposure prophylaxis for 2 health care workers显示文摘 | Sha BE Proia LA Kessler HA | 2000 | JAMA2000，284，12： | 1 |
| 20 | Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey显示文摘 | Kessler RC Crum RM Warner LA | 1997 | Arch Gen Psy- chiatry1997，54，4： | 1 |
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