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| 1 | Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants显示文摘The process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases(MMPs). Degradation of extracellular matrix(ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-teinase(TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK(reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2,-9 and-14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species(ROS) through mitochondrial dysfunction leading to altered protease/anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. | Sugreev Verma Kousik Kesh Nilanjan Ganguly Sayantan Jana Snehasikta Swarnakar | 2014 | World Journal of Biological Chemistry2014，5，3： | 10 |
| 2 | DYNAMICS ANALYSIS OF SPECIAL STRUCTURE OF MILLING-HEAD MACHINE TOOL显示文摘The milling-head machine tool is a sophisticated and high-quality machine tool of which the spindle system is made up of special multi-element structure.Two special mechanical configurations make the cutting performance of the machine tool decline.One is the milling head spindle supported on two sets of complex bearings.The mechanical dynamic rigidity of milling head structure is researched on designed digital prototype with finite element analysis(FEA) and modal synthesis analysis (MSA) for identifying the weak structures.The other is the ram structure hanging on milling head.The structure is researched to get dynamic performance on cutting at different ram extending positions.The analysis results on spindle and ram are used to improve the mechanical configurations and structure in design.The machine tool is built up with modified structure and gets better dynamic rigidity than it was before. | YANG Qingdong LIU Guoqing WANG Keshe | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 8 |
| 3 | Contact resistivity reduction through interfacial layer doping in metal-interfacial layer-semiconductor contacts显示文摘 | GUPTA S PARAMAHANS M P KESH M R | 2013 | J Appl Phys2013，113，23： | 1 |
| 4 | Fermi-level unpinning and low resistivity in contacts to n-type Ge with a thin Zn O interfacial layer显示文摘 | PARAMAHANS M P KESH M R PAVAN K V | 2012 | Appl Phys Lett2012，101，18： | 1 |
| 5 | A framework for analyzing e-commerce security显示文摘 | Someswar Kesh Sam Ramanujan Sridhar Nerur | 2002 | Journal of In- formation Management & Computer Security2002，，4： | 1 |
| 6 | Combating severe fluid erosion and corrosion of drilling bits using thermal spray coatings显示文摘 | KEMBAIYAN K T KESH KESHAVEN | 1995 | wear1995，，186187： | 1 |
| 7 | An overview of matrix metalloproteinase 9 polymorphism and gastric cancer risk 显示文摘 | Verma S Kesh K Gupta A | 2015 | Asian Pac J Cancer Prey2015，16，7： | 1 |
| 8 | TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation 显示文摘 | KESH S MENSAH NY PETERLONGO P | 2005 | Ann N Y Acad Sci2005，1062，： | 1 |
| 9 | High dose iept in activates human leuko- cy tes viar eccp to rexpressio non monocytes 显示文摘 | zar kesh Esfahani H Pockley G Metcalfe RA | 2001 | J Immuno l2001，67，8： | 1 |
| 10 | The Effects of Nonuniform and Correlated Noise on Superresolution Algorithms 显示文摘 | Don Torrieri Kesh Bakhru | 1997 | IEEE Trans AP1997，45，8： | 1 |
| 11 | An Overview of Matrix Metalloproteinase 9 Polymorphism and Gastric Cancer Risk显示文摘 | Verma S Kesh K Gupta A | 2015 | Asian Pae J Cancer Prey2015，16，17： | 1 |
| 12 | Brainstem evoked response audiometry (BAER) in neonates with hyperbilirubinemia显示文摘 | Pramod Sharma N. P. Chhangani Kesh Ram Meena Rakesh Jora Navratan Sharma B. D. Gupta | 2006 | The Indian Journal of Pediatrics2006，，5： | 1 |
| 13 | TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation显示文摘 | KESH S MENSAH N Y PETERLONGO P | 2005 | Ann N Y Acad Sci2005，1026，95： | 1 |
| 14 | Case-based reasoning显示文摘 | Kesh S | 1995 | Journal of Systems Management1995，46，4： | 1 |
| 15 | TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation 显示文摘 | Kesh S Mensah NY Peterlongo P | 2005 | Ann N Y Acad Sci2005，1062，： | 1 |
| 16 | Differential protein expression profiling by iTRAQ-2DLC-MS/MS of lung cancer cells undergoing epithelial mesenchymal transition reveals a migratory/invasive phenotype显示文摘 | Kesh amouni VG Michailidis G Grasso CS | 2006 | J Proteome Res2006，5，5： | 1 |
| 17 | An overview of matrix met- alloproteinase 9 polymorphism and gastric cancer risk 显示文摘 | VERMA S KESH K GUPTA A | 2015 | Asian Pac J Cancer Prey2015，16，17： | 1 |
| 18 | Measurement of cerebral oxyhaemoglobin saturation and jugular blood flow in term healthy newborn infants by near-infrared spectroscopy and jugular venous occlusion显示文摘 | Buchvald F Keshe K Griesen G | 1999 | Biol Neonate1999，75，2： | 1 |
| 19 | TLR1 and TLR6 poly-morphisms are associated with susceptibility to invasive aspergillo- sis after allogeneic stem cell transplantation显示文摘 | Kesh S Mensah NY Peterlongo P | 2005 | Ann N Y Acad Sci2005，1062，： | 1 |
| 20 | Evalua tion and comparison of three different anti hepatilis i virus antibody tests based on chemiluminescence and enzyme-linked immunosorbent assay methods used in the diagnosis of hepatitis C infections in Turkey显示文摘 | Kesh R Ozxlemir M Kurtoglu MG | 2009 | J Int Med Res2009，37，： | 1 |
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