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| 1 | Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis显示文摘AIM To investigate of pediatric ulcerative colitis activity index(PUCAI) in ulcerative colitis correlate with mucosal inflammation and endoscopic assessment of disease activity(Mayo endoscopic score).METHODS We reviewed charts from ulcerative colitis patients who had undergone both colonoscopy over 3 years. Clinical assessment of disease severity within 35 d(either before or after) the colonoscopy were included. Patients were excluded if they had significant therapeutic interventions(such as the start of corticosteroids or immunosuppressive agents) between the colonoscopy and the clinical assessment. Mayoendoscopic score of the rectum and sigmoid were done by two gastroenterologists. Inter-observer variability in Mayo score was assessed.RESULTS We identified 99 patients(53% female, 74% pancolitis) that met inclusion criteria. The indications for colonoscopy included ongoing disease activity(62%), consideration of medication change(10%), assessment of medication efficacy(14%), and cancer screening(14%). Based on PUCAI scores, 33% of patients were in remission, 39% had mild disease, 23% had moderate disease, and 4% had severe disease. There was 'moderate-substantial' agreement between the two reviewers in assessing rectal Mayo scores(kappa = 0.54, 95%CI: 0.41-0.68). CONCLUSION Endoscopic disease severity(Mayo score) assessed by reviewing photographs of pediatric colonoscopy has moderate inter-rater reliability, and agreement was less robust in assessing patients with mild disease activity. Endoscopic disease severity generally correlates with clinical disease severity as measured by PUCAI score. However, children with inflamed colons can have significant variation in their reported clinical symptoms. Thus, assessment of both clinical symptoms and endoscopic disease severity may be required in future clinical studies. | Basavaraj Kerur Heather J Litman Julia Bender Stern Sarah Weber Jenifer R Lightdale Paul A Rufo Athos Bousvaros | 2017 | World Journal of Gastroenterology2017，23，18： | 5 |
| 2 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | Genetic characterization ofIndian peste des petits ruminants virus (PPRV) by sequencing and phylogenetic analysis of fusion protein and nucleoprotein gene segments 显示文摘 | Kerur N Jhala MK Joshi CG | 2008 | Research in Veterinary Science2008，85，： | 1 |
| 4 | IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection显示文摘 | Nagaraj Kerur Mohanan Valiya Veettil Neelam Sharma-Walia Virginie Bottero Sathish Sadagopan Pushpalatha Otageri Bala Chandran | 2011 | Cell Host & Microbe2011，，5： | 1 |
| 5 | Active control of geometrically nonlinear transient response of smart laminated composite plate integrated with AFC actuator and PVDF sensor显示文摘 | Kerur S K Ghosh A | 2011 | Journal of Intelligent Material Systems and Structures2011，22，： | 1 |
| 6 | Thrombotic events in criti- cally ill children with myocarditis显示文摘 | Lin KY Kerur B Witmer CM | 2014 | Cardiol Young2014，24，5： | 1 |
| 7 | IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus in-fection显示文摘 | Kerur N Veettil MV Sharma-Walia Nv | 2011 | Cell Host Microbe2011，9，5： | 1 |
| 8 | Maternal genital bacteria and surface colonization in early neonatal sepsis显示文摘 | Kerur BM Vishnu Bhat B Harish BN | 2006 | Indian J Pediatr2006，73，1： | 1 |
| 9 | IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma associated herpesvirus infection显示文摘 | Kerur N Veettil MV Sharma-Walia N | 2011 | Cell Host Microbe2011，9，5： | 1 |
| 10 | IFI16 act as a nuclear pathogen sensor to induce the inflammasome in response to kaposi sarcoma-associated herpesvirus infection显示文摘 | KERUR N VEE33'IL M V SHARMA-WALIA N | 2011 | Cell Host Microbe2011，9，5： | 1 |
| 11 | IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi sarcoma-associated herpes virus infection 显示文摘 | Kerur N Veettil MV Sharmawalia N | 2011 | Cell Host Microbe2011，9，5： | 1 |
| 12 | TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3inflammasome activation in geographic atrophy显示文摘 | Kerur N Hirano Y Tarallo V | 2013 | Invest Ophthalmol Vis Sci2013，54，12： | 1 |
| 13 | Genetic characterization of Indian Peste des petits ruminants virus (PPRV) by sequencing and phylogenetic analysis of fusion protein and nucleoprotein gene segments显示文摘 | Kerur N Jhala MK Joshi CG | 2007 | Res Vet Sci2007，26，10： | 1 |
| 14 | IFI16 acts as a nuclearpathogen sensor to induce the inflammasome in response to KaposiSarcoma-associated herpesvirus infection 显示文摘 | Kerur N Veettil MV Sharma-Walia N | 2011 | Cell Host Microbe2011，9，5： | 1 |
| 15 | Polymeric ocular nanosus-pension for controlled release of acyclovir:in vitro release andocular distribution显示文摘 | P Kerur S Mastiholimath V | 2009 | J Pharm Res2009，8，2： | 1 |
| 16 | Genetic characterization of Indian peste des petits ruminants virus (PPRV) by se- quencing and phylogenetic analysis of fusion protein and nucleoprotein genesegments显示文摘 | Kerur N Jhala M K Joshi | 2007 | Res Vet Sci2007，85，1： | 1 |
| 17 | Kaposi's sarcoma-associated her- pesvirus latency in endothelial and B cells activates gamma interferon- inducible protein 16-mediated inflammasomes 显示文摘 | Singh VV Kerur N Bottero V | 2013 | J Virol2013，87，8： | 1 |
| 18 | Penicillium Mycelium Waste as Protein Supplement in Animals显示文摘 | Doctor V M Kerur L | 1968 | Applied Microbiology1968，16，11： | 1 |
| 19 | Maternal genital bacteria and surface colonization in early neonatal sepsis 显示文摘 | Kerur BM Vishnu Bhat B Harish BN | 2006 | Indian J Pediatr2006，73，1： | 1 |
| 20 | Genetic characterization of Indian peste des petits ruminants virus (PPRV) by sequencing and phylogenetie analysis of fusion protein and nucleoprotein gene segments 显示文摘 | Kerur N Jhala MK Joshi CG | 2007 | Res Vet Sci2007，26，10： | 1 |
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