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| 1 | Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis显示文摘AIM:To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP). METHODS:Forty-eight rats were randomly divided into 3 groups. AP was induced by intraperitoneal (i.p.) injection of cerulein (50 μg/kg) four times,at 1 h intervals. The rats received a single i.p. injection of 10 μg/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. In the sham group,animals were given a single i.p. injection of 2 mL saline. Experimental samples were collected for biochemical and histological evaluations at 24 h and 48 h after the induction of AP or saline administration. Blood samples were obtained for the determination of amylase,lipase,tumor necrosis factor (TNF)-a,interleukin (IL)-1β,macrophage inflammatory peptide (MIP)-2 and soluble intercellular adhesion molecule (sICAM)-1 levels,while pancreatic and lung tissues were removed for myeloperoxidase (MPO) activity,nitric oxide (NOx) level,CD40 expression and histological evaluation. RESULTS:Cerulein injection caused severe AP,confirmed by an increase in serum amylase and lipase levels,histopathological findings of severe AP,and pancreatic MPO activity,compared to the values obtained in the sham group. In the leptin group,serum levels of MIP-2,sICMA-1,TNF-a,and IL-1b,pancreatic MPO activity,CD40 expression in pancreas and lung tissues,and NOx level in the lung tissue were lower compared to those in the AP group. Histologically,pancreatic and lungdamage was less severe following leptin administration. CONCLUSION:Exogenous leptin attenuates inflammatory changes,and reduces pro-inflammatory cytokines,nitric oxide levels,and CD40 expression in ceruleininduced AP and may be protective in AP associated ALI. | Fatma Ayca Gultekin Mustafa Kerem Ertan Tatlicioglu Aysel Aricioglu Cigdem Unsal Neslihan Bukan | 2007 | World Journal of Gastroenterology2007，13，21： | 23 |
| 2 | Coexistence of Mirizzi syndrome with adenomyomatosis in the gallbladder:report of a case显示文摘BACKGROUND:Mirizzi syndrome is a rare complication of cholelithiasis. Adenomyomatosis is a common tumor-like lesion of the gallbladder. METHODS:A 52-year-old man was admitted to our hospital complaining of right hypochondriac pain and jaundice. Ultrasonography and computed tomography revealed stones in the gallbladder and dilation of the intrahepatic bile ducts. Magnetic resonance cholangiopancreatography revealed narrowing of the common bile duct caused by compression of the gallbladder. Laparotomy revealed type Ⅱ Mirizzi syndrome. RESULTS:Partial cholecystectomy with a Roux-en-Y hepaticojejunostomy reconstruction was performed. Histologically,Rokitansky-Aschoff sinus proliferation,hypertrophy of smooth muscles,and fibrosis were seen in the gallbladder. A segmental type of adenomyomatosis of the gallbladder was diagnosed. CONCLUSIONS:The pathogenic link between the two peculiar entities is unclear. A possible explanation is considered that the pathogenesis of Mirizzi syndrome is resulted from chronic inflammation due to adenomyomatosis. | Abdulkadir Bedirli Mustafa Kerem Hasan Bostanci Tarkan Karakan T. Tolga Sahin Nalan Akyurek | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，4： | 10 |
| 3 | Adipokines and ghrelin in gastric cancer cachexia显示文摘AIM:To investigate the roles of the adipocytokines,ghrelin and leptin in gastric cancer cachexia. METHODS:Resistin,ghrelin,leptin,adiponectin,insulin and insulin-like growth factor(IGF-Ⅰ),were measured in 30 healthy subjects,and 60 gastric cancer patients of which 30 suffered from cancer-induced cachexia and 30 served as a control group. The relationships between hormones,body mass index(BMI) loss ratio,age,gender,and Glasgow Prognostic Score(GPS) were investigated. RESULTS:Cachexia patients had higher tumor stage and GPS when compared with non-cachexia patients(P < 0.05). Ghrelin,resistin,leptin,adiponectin and IGF-Ⅰ,showed a significant correlation with BMI loss ratio and GPS(P < 0.05). A strong correlation was seen between GPS and BMI loss(R = -0.570,P < 0.0001). Multivariate analysis indicated that BMI loss was significantly independent as a predictor of ghrelin,resistin,leptin and IGF-Ⅰ(P < 0.05). Existence of an important significant relationship between resistin and insulin resistance was also noted. CONCLUSION:These results showed that serum ghrelin,leptin,adiponectin,and IGF-Ⅰ play important roles in cachexia-related gastric cancers. No relationshipwas found between resistin and cancer cachexia. Also,because of the correlation between these parameters and GPS,these parameters might be used as a predictor factor. | Mustafa Kerem Zafer Ferahkose Utku Tonguc Yilmaz Hatice Pasaoglu Ebru Ofluoglu Abdulkadir Bedirli Bulent Salman Tevfik Tolga Sahin Murat Akin | 2008 | World Journal of Gastroenterology2008，14，23： | 4 |
| 4 | 冷却系统阻力对汽车总阻力影响的数值预测模型研究(英文)显示文摘采用CFD方法数值模拟了小型汽车发动机冷却系统对全车阻力的影响特性。汽车的内部及外部(发动机舱及舱内)均设置了数值模拟网格。分别计算了散热器及风扇对阻力的影响,采用本校实验结果(散热器压力损失)及制造商提供的数据(散热器及风扇的质量流率)确定初始及边界条件,为基于RNS的CFD提供输入。对汽车轮胎运动模式及行驶速度对散热系统阻力及汽车总阻的影响特性也进行了计算分析。预测结果表明,冷却系统阻力占汽车总阻的6.9%,与实测值吻合。 | A. Rustem Aslan Kerem Anbarci M.Berkay Acikgoz Omur Icke Ozgur Asian Cenk Dinc | 2016 | 空气动力学学报2016，34，2： | 4 |
| 5 | Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development显示文摘 | Assaf C. Bester Maayan Roniger Yifat S. Oren Michael M. Im Dan Sarni Malka Chaoat Aaron Bensimon Gideon Zamir Donna S. Shewach Batsheva Kerem | 2011 | Cell2011，，3： | 2 |
| 6 | Specifc inflammatory osteoclast precursors induced during chronic inflammation give rise to highly active osteoclasts associated with inflammatory bone loss显示文摘Elevated osteoclast(OC)activity is a major contributor to inflammatory bone loss(IBL)during chronic inflammatory diseases.However,the specific OC precursors(OCPs)responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood.We identified two distinct OCP subsets:Ly6C^(hi)CD11b^(hi) inflammatory OCPs(iOCPs)induced during chronic inflammation,and homeostatic Ly6C^(hi)CD11b^(lo)OCPs(hOCPs)which remained unchanged.Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions,they expanded during chronic inflammation and generated OCs with enhanced activity.In contrast,hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment.Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs,highlighting that different osteoclast populations are formed by distinct precursors.We further identified the TNF-αand S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation.Furthermore,we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α^(-/-)mice,in correlation with attenuated IBL.Our findings suggest a central role for iOCPs in IBL induction.iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions. | Yaron Meirow Milena Jovanovic Yuval Zur Juliana Habib Daniele Filippo Colombo Nira Twaik Hadas Ashkenazi-Preiser Kerem Ben-Meir Ivan Mikula Jr. Or Reuven Guy Kariv Leonor Daniel Saja Baraghithy Yehuda Klein Jeroen Krijgsveld Noam Levaot Michal Baniyash | 2022 | Bone Research2022，10，3： | 2 |
| 7 | 真空辅助熔模铸造制备A6063/SiC-B_4C混杂复合材料(英文)显示文摘采用真空辅助熔模铸造技术制备A6063/SiC-B4C混杂复合材料。首先,采用平均粒径分别为60μm和55μm、质量比为85%和15%的SiC和B4C粉末制备圆柱形的SiC-B4C预制块。然后,将预制块放入圆柱形石膏粘结块熔模中,在真空辅助铸造机中将A6063铝熔体浸渗到预制块中。采用阿基米德方法测定预制块中的孔隙度。对制备的复合材料进行硬度测试、图像分析、SEM观察和EDX成分分析。结果表明,采用真空辅助熔模铸造技术,铝熔体能将够成功地浸渗到预制块中。 | Alptekin KISASOZ Kerem Altug GULER Ahmet KARAASLAN | 2012 | Transactions of Nonferrous Metals Society of China2012，22，7： | 2 |
| 8 | Investigation of carbon contamination in lost foam castings of low carbon steel显示文摘Lost foam casting(LFC) process is a special casting method in which polymeric foam patterns with refractory coatings are utilized as a mould component. In this work, four types of foam: expandable polyethylene(EPE), expandable polypropylene(EPP) and expandable polystyrene(EPS) foams with two different densities were employed as pattern materials. LFC and conventional green sand mould casting methods were used to cast a low carbon steel, A216 Grade WCB. Both casting processes were carried out at 1,580 °C. Chemical analysis results showed that the carbon contamination level was high and was influenced by pattern type. Metallographic investigations revealed a significant increase in the percentage of pearlite phase in all LFC samples. Densities of manufactured samples were calculated in order to evaluate porosity of the products. It was determined that the densities of the LFC samples were lower than the green sand mould cast reference sample(RS). Vickers hardness tests were also carried out and increments in hardness values with increased carbon content was observed. | Oznur Kilic Serhat Acar Alptekin Kisasoz Kerem Altug Guler | 2018 | China Foundry2018，15，5： | 2 |
| 9 | T6热处理对触变锻造加低过热铸造制备的A356和A380铝合金的影响(英文)显示文摘研究T6热处理对触变锻造A356和A380铝合金的影响。采用低过热铸造(LSC)技术制备用于触变锻造的样品。为了获得等轴晶粒并防止枝晶生长,将样品在高于液相温度20°C时进行浇铸,将浇铸坯料再加热不同时间(20~80 min)后进行触变锻造,变形量为50%,再将触变锻造后的A356和A380铝合金样品进行T6热处理。用光学显微镜、能量弥散X射线谱仪、扫描电镜和布氏硬度仪对经触变锻造、固溶处理和时效处理后样品的显微组织和硬度变化进行检测。结果表明,T6热处理后合金的显微组织更均匀,并分别在A356和A380坯料中形成了新的析出相Mg_2Si和Al_2Cu。相应地,经过人工时效后,样品的硬度大幅度提高,A356铝合金的硬度达到HB 93,A380铝合金的硬度达到HB 120。 | Ridvan GECU Serhat ACAR Alptekin KISASOZ Kerem ALTUG GULER Ahmet KARAASLAN | 2018 | Transactions of Nonferrous Metals Society of China2018，28，3： | 2 |
| 10 | Invariant chain, a chain of command显示文摘 | Matza D Kerem A Shachar I | 2003 | Trends in Immunology2003，24，： | 1 |
| 11 | Identification of the cystic fibrosis gene:genetic analysis显示文摘 | Kerem B Rommens JM Buchanan JA Markiewicz D Cox TK Chakravarti A | | 0，，： | 1 |
| 12 | Chemical constituents from Rumex bucephalorus 显示文摘 | Kerem Z Regev S G Flaishman M A | 2003 | J Nat Prod2003，66，9： | 1 |
| 13 | The biological action of saponins in animal systems: a review显示文摘 | FRANCIS G KEREM Z MAKKAR H P | 2002 | British Journal of Nutrition2002，88，6： | 1 |
| 14 | Developmental Dyscalculia is a Familial Learning Disability显示文摘 | SHALEV R S MANOR O KEREM B | 2001 | Journal of Learning Disabilities2001，34，1： | 1 |
| 15 | Alopecia treat ment with scalp expansion : some surgical fine points and a simple modification to improve the resuhs显示文摘 | Bilkay U Kerem H Ozek C | 2004 | The Journal of Craniofacial Surgery2004，27，12： | 1 |
| 16 | Long-term patency of sequential and in- dividual saphenous vein coronary bypass grafts 显示文摘 | Kerem M Sener E Tasdemir O | 2001 | Eur J Cardiovasc Surg2001，19，2： | 1 |
| 17 | The cranially based contralateral nasolabial flap for reconstruction of paranasal and periorbital surgical defects显示文摘 | KEREM H BALI U SONMEZ E | 2014 | J Plast Reconstr Aesthet Surg2014，67，： | 1 |
| 18 | Midterm results of total knee arthroplasty in degenerative knee joint diseases with severe deformity显示文摘 | Bahaddin Guael Kerem Basarir | 2008 | Acts Orthop Traumatol Turc2008，42，1： | 1 |
| 19 | Identifcation of the cystic fibrosis gene:cloning and characterization of complementary DNA显示文摘 | Riordan JR K0nlolens JM Kerem B | 1989 | Science1989，245，： | 1 |
| 20 | Identification of the cystic fi- brosis gene: chromosome walking and jumping显示文摘 | Rommens JM lannuzzi MC Kerem B | 1989 | Science1989，245，： | 1 |
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