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| 1 | DESIGN METHODOLOGY OF NETWORKED SOFTWARE EVOLUTION GROWTH BASED ON SOFTWARE PATTERNS显示文摘最近,建筑群的新特征联网的一些在不同领域里吸引科学家的注意,并且导致许多种新兴的研究方向。到目前为止,大多数研究工作被结构分析在大规模软件系统在复杂网络特征的发现限制了。这篇论文论述理论基础,设计方法,算法和研究的实验结果。它第一为网络拓扑学强调进化生长的设计方法的意义面向对象(OO ) 软件系统,并且主张有各种各样的拓扑学特征的网络模型的选择和调整将在设计的进程和 OO 软件系统的实现上带不可忽略的效果。然后,我们与不同拓扑学特征和软件建模方法的发展分析“在网络模型的进化之间的否定和妥协的否定”的类似的纪律。根据软件模式的生长特征的分析,我们连续建议一个面向对象的软件网络进化生长方法和它的算法。另外,我们也基于复杂网络理论为 OO 软件系统度量标准建议参数系统。基于这些参数系统,它能分析各种各样的节点的特征,连接并且本地世界,调制网络拓扑学并且指导软件度量标准。所有这些能对详细设计,实现和表演分析有用。最后,我们集中于进化算法的应用程序并且由案例研究表明它。在实验软件工程从我们的早实验把结果与方法论作比较,我们相信建议软件工程设计方法基于复杂网络理论是一条计算软件工程途径。我们主张这个方法应该是极大地为在大规模 OO 的功能,结构和性能的设计,实现,调整和度量标准有益软件建筑群系统。 | Keqing HE Rong PENG Jing LIU Fei HE Peng LIANG Bing LI | 2006 | Journal of Systems Science & Complexity2006，19，2： | 24 |
| 2 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 3 | Zircon U–Pb and Hf isotopic study of Neoproterozoic granitic gneisses from the Alatage area, Xinjiang:constraints on the Precambrian crustal evolution in the Central Tianshan Block显示文摘The architecture and growth history of Precambrian crustal basements in the Central Tianshan Block play a key role in understanding the tectonic evolution of the Chinese Tianshan Orogenic Belt.In this study,we present precise LA-ICP-MS zircon U–Pb dating and LAMC-ICPMS zircon Hf isotopic data for two granitic gneisses from Alatage area in the Central Tianshan Block.The magmatic zircons from both samples yield similar protolith ages of 945±6 and 942±6 Ma,indicating that the early Neoproterozoic magmatism is prevailed in the Alatage area.These zircons have crustal Hf model ages of1.82–2.22 and 1.70–2.03 Ga,respectively,which are significantly older than their crystallization ages.It indicates that their parental magmas were derived from the reworking of ancient crust.However,we suggest that these Paleoproterozoic Hf model ages might result from mixing of continental materials with different ages in the Neoproterozoic crust.The inherited(detrital)zircon cores not only yield a wide age range of ca.989–1617 Ma,but also exhibit large Hf-isotope variations with Hf model ages of1.54–2.30 Ga.In particular,some 1.4–1.6 Ga zircons show high initial176Hf/177Hf ratios,consistent with those of depleted mantle,which indicates that the Mesoproterozoic event involved both reworking of older crust and generation of juvenile crust.The Central Tianshan Block has different Precambrian crustal growth history from the Tarim Craton.Therefore,it would not be a fragment of the Precambrian basement of the Tarim Craton. | Botao Huang Zhenyu He Keqing Zong Zeming Zhang | 2014 | Chinese Science Bulletin2014，59，1： | 12 |
| 4 | Leveraging Auxiliary Knowledge for Web Service Clustering显示文摘By grouping Web services that share similar functionalities, Web service clustering can greatly enhance Web service discovery and selection. Most existing clustering techniques are designed to handle long text documents. However, the descriptions of most publicly available Web services are in the form of short text, which impairs the quality of service clustering due to the sparseness of useful information. Towards this issue, we propose a new service clustering approach based on transfer learning from auxiliary long text data obtained from Wikipedia.To handle the inconsistencies in semantics and topics between service descriptions and auxiliary data, we introduce a novel topic model – Tag aided dual Author topical model(TD-ATM), which jointly learns two sets of topics on the two data sets and automatically couples the topic parameters to avoid the potential inconsistencies between these two data sets. Experimental results show the proposed approach outperforms several existing Web service clustering approaches. | TIAN Gang WANG Jian HE Keqing SUN Cheng'ai | 2016 | Chinese Journal of Electronics2016，25，5： | 5 |
| 5 | Meta-modeling of Requirement for Networked Software-An Open Hierarchical & Cooperative Unified Requirement Framework URF 显示文摘 | He Keqing Liang Peng Li Bing | 2007 | DCDIS-B2007，14，6： | 1 |
| 6 | Non-matrix-matched analysis of U-Th-Pb geochronology of bastn?site by laser ablation inductively coupled plasma mass spectrometry显示文摘Bastn?site is widespread in alkali granite, carbonatite and REE ore deposits. The U-Th-Pb ages of bastn?site can constrain the mineralization age. Currently, the lack of suitable in situ analysis reference material is the major obstacle of bastn?site U-Th-Pb geochronology. In this study, the matrix effects of U-Pb and Th-Pb age determination in bastn?site using glass NIST 610 as the external calibration reference were evaluated with the 193-nm excimer LA-ICP-MS analysis in normal and additional gases laser ablation modes. The obtained U-Th-Pb ages of bastn?site were approximately 7–11% lower than their reference values in the normal analytical mode(without additional gas). Fortunately, the determined systematic age biases in UTh-Pb dating were significantly reduced(less than 1–2%) with the addition of water vapor within the ablation chamber. This reduction may be attributed to the observed significant suppression of206 Pb/238 U and208 Pb/232 Th downhole fractionation in both NIST 610 glass and bastn?site by introducing a small quantity of water vapor in the ablation chamber. In addition, the obtained206 Pb/238 U and208 Pb/232 Th ages of bastn?site K-9, LZ1384, and MAD809 showed great consistency with their corresponding recommended values. The obtained results show that accurate and precise U-Th-Pb ages of bastn?site can be simultaneously obtained by using glass NIST 610 as the primary calibration standard in 193-nm LA-ICP-MS with the water vapor-assisted method. This simple and effective water vapor-assisted non-matrix-matched laser ablation method helps to promote the geological application of bastn?site U-Th-Pb geochronology. | Tao LUO He ZHAO Wen ZHANG Jingliang GUO Keqing ZONG Yongsheng LIU Junfeng ZHANG Zhaochu HU | 2021 | Science China Earth Sciences2021，64，4： | 1 |
| 7 | A transformation definition metamodel for model transformation 显示文摘 | Liu Jin He Keqing Li Bing | 2005 | International Conference on Information Technology: Coding and Computing ITCC2005，2，1： | 1 |
| 8 | 5-methyl-2--benzenesuifonic acid as a chromogenic reagent of N -cetylpytidinium chloride Synthesis,mechanism and analytical application显示文摘 | HE Xiaoling WANG Yongqiu LING Keqing | 2008 | Talanta2008，74，： | 1 |
| 9 | 5-Methyl-2-benzenesulfonic acid as a chromogenic rengent of N-cetylpyridinium chloride synthesis,mechanism and analytical application显示文摘 | HE Xiaoling WANG Yongqiu LING Keqing | 2008 | Talanta2008，74，： | 1 |
| 10 | Web service aggrega tion using semantic interoperability oriented method显示文摘 | Jianxiao Liu Keqing He Da Ning | | 0，，03： | 1 |
| 11 | Requirements dynamic elicitation and analysis:heavyweight semantic inducement solution显示文摘 | Liu Wei He Keqing | 2007 | Special Issue on Software Engineering and Complex Networks:DCDIS Series B2007，14，6： | 1 |
| 12 | Meta modeling of requirement for networked software--An open hierarchical & cooperative unified requirement framework URF 显示文摘 | He Keqing Liang Peng Li Bing | 2007 | Dynamics of Continuous Discrete and Impulsive Systems: Series B Applications and Algorithms2007，14，6： | 1 |
| 13 | Web Service Aggregation Using Semantic Interoperability Oriented Method显示文摘 | Liu Jianxiao He Keqing Ning Da | 2012 | Journal of Information Science and Engineering2012，28，3： | 1 |
| 14 | Requirements Dynamic Elicitation and Analysis:Heavyweight Semantic Inducement Solution显示文摘 | Liu Wei He Keqing | 2007 | Special Issue on Software Engineering and Complex Networks DCDIS Series B2007，14，6： | 1 |
| 15 | Towards Semantic Interoperability Aggregation in Service Requirements Refinement显示文摘 | HE Keqing WANG Jian LIANG Peng | 2010 | Journal of Computer Science and Technology2010，25，3： | 1 |
| 16 | 5-Methyl-2- benzenesulfonic acid as achromogenic rengent of N-cetylpyridinium chloride synthesis, mechanism and analytical application 显示文摘 | HE Xiaoling WANG Yongqiu LING Keqing | 2008 | Talanta2008，74，： | 1 |
| 17 | Requirement E mergence Computation of Networked Software 显示文摘 | He Keqing Liang Peng Peng Rong | 2007 | Frontier of Computer Science in China2007，1，3： | 1 |
| 18 | Meta- modeling of Requirement for Networked Software-An Open Hierarchical & Cooperative Unified Requirement Framework URF显示文摘 | He Keqing Liang Peng Li Bing et at | 2007 | Dynamics of Contiunous Discrete and Impulsive Systems (Series B:Applications and Algorithms)2007，14，6： | 1 |
| 19 | 5 - Methyl - 2 - - benzenesulfonic acid as a chromogenic reagent of N -cetylpyridinium chloride synthesis,mecha- nism and analytical application 显示文摘 | HE XIAOLING WANG YONGQIU LING KEQING | 2008 | Talanta2008，74，： | 1 |
| 20 | Detector development at the Back-n white neutron source显示文摘Purpose Back-n is a white neutron beamline at China spallation neutron source,which was established in the year of 2018.It is a powerful facility for nuclear data measurement,neutron detector calibration,and radiation effect research.Method A series of detectors were built for different experiments,including beam monitoring,beam profile measurement,neutron induced secondaries(fission fragments,light charged particles and gamma)cross section measurement,and neutron resonance radiography,etc.A common digitization electronics and a cluster-based DAQ were developed for these detector systems.Most detectors have been employed at Back-n and serviced for experiments from the beginning of the beamline running.Results and conclusion As an overview of detectors of Back-n,the details of the detector design and the experiment performing are described in this paper.Some developing systems,e.g.,MTPC and B-MCP,are also included. | Fan Ruirui Li Qiang Bao Jie Li Yang Liu Rong Jiang Wei Ren Jie Zhang Qiwei Cao Ping Gu Minhao Ren Zhizhou Yi Han Tang Jingyu An Qi Bai Haofan Bai Jiangbo Chen Qiping Chen Yonghao Chen Zhen Cui Zengqi Fan Anchuan Feng Changqing Feng Fanzhen Gao Keqing Han Changcai Han Zijie He Guozhu He Yongcheng Hong Yang Hu Yiwei Huang Hanxiong Jia Weihua Jiang Haoyu Jiang Zhijie Jin Zhengyao Kang Ling Li Bo Li Chao Li Gong Li Jiawen Li Xiao Liu Jie Liu Shubin Luan Guangyuan Ning Changjun Qi Binbin Ruan Xichao Song Zhaohui Sun Kang Tan Zhixin Tang Shengda Wang Pengcheng Wang Zhaohui Wen Zhongwei Wu Xiaoguang Wu Xuan Xie Likun Yang Yiwei Yu Yongji Zhang Guohui Zhang Linhao Zhang Mohan Zhang Xianpeng Zhang Yuliang Zhang Yue Zhang Zhiyong Zhao Maoyuan Zhou Luping Zhou Zhihao Zhu Kejun The CSNS Back-n Collaboration | 2023 | Radiation Detection Technology and Methods2023，7，2： | 0 |
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