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| 1 | Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole显示文摘AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg(n = 201), vonoprazan 10 mg(n = 202), or vonoprazan 20 mg(n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maintenance treatment. Additional efficacy endpoints included the incidence of heartburn and acid reflux, and the EE healing rate 4 wk after the initiation of maintenance treatment. Safety endpoints comprised adverse events(AEs), vital signs, electrocardiogram findings, clinical laboratory results, serum gastrin and pepsinogen Ⅰ/Ⅱ levels, and gastric mucosa histopathology results.RESULTS Rates of EE recurrence during the 24-wk maintenance period were 16.8%, 5.1%, and 2.0% with lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg, respectively. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg(P < 0.0001 for both doses). In a post-hoc analysis, EE recurrence at Week 24 was significantly reduced with vonoprazan at both the 10 mg and the 20 mg dose vs lansoprazole 15 mg(5.1% vs 16.8%, P = 0.0002, and 2.0% vs 16.8%, P < 0.0001, respectively); by contrast, the EE recurrence rate did not differ significantly between the two doses of vonoprazan(P = 0.1090). The safety profiles of vonoprazan 10 and 20 mg were similar to that of lansoprazole 15 mg in patients with healed EE. Treatment-related AEs were reported in 11.4%, 10.4%, and 10.3% of patients in the lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg arms, respectively.CONCLUSION Our findings confirm the non-inferiority of vonoprazan 10 and 20 mg to lansoprazole 15 mg as maintenance therapy for patients with healed EE. | Kiyoshi Ashida Katsuhiko Iwakiri Naoki Hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki | 2018 | World Journal of Gastroenterology2018，24，14： | 18 |
| 2 | Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction显示文摘Esophageal lymphoepithelioma-like carcinoma(LELC) is extremely rare. We report the first case of esopha-geal LELC showing macroscopic reduction. A 67-year-old male presented with dysphagia and, by endoscopic examination, was found to have a significantly raised tumor of 10 mm in diameter in the thoracic esophagus. The biopsied material showed esophageal cancer. We performed endoscopic submucosal dissection. However, the tumor became flattened, similar to a scar, in only 2 mo. Histologically, the carcinoma cells had infiltrated the submucosal layer. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed aroundthe carcinoma cells. Therefore, this lesion was consid-ered to be an LELC with poorly differentiated squamous cells. Because the margin was positive, an esophagec-tomy was performed. Carcinoma cells were detected in the neck in one lymph node. The staging was T1N0M1 b. However, the patient has been well, without adjuvant therapy or recurrence, for more than 5 years. | Masaya Uesato Tuguaki Kono Tooru Shiratori Yasunori Akutsu Isamu Hoshino Kentarou Murakami Daisuke Horibe Tetsurou Maruyama Yoshihide Semba Ryuma Urahama Yukiko Ogura Takashi Oide Toru Tanizawa Hisahiro Matsubara | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 6 |
| 3 | Gastric endoscopic submucosal dissection via gastrostoma before the second operation for esophageal perforation: A case report显示文摘A 69-year-old man with advanced esophageal cancer and 2 early gastric cancers received chemoradiotherapy and was scheduled to undergo subtotal esophagectomy after gastric endoscopic submucosal dissection(ESD). However, left lower esophageal perforation induced by vomiting suddenly occurred, and he urgently underwent esophago-proximal gastrectomy and gastrostomy without reconstruction. The resected specimen showed a complete response of pretreatment for the esophageal cancer and radical resection of one gastric cancer. Radical resection of the other gastric lesion was necessary before reconstruction. The fistula of gastrostoma was gradually dilated from 6.7 to 9.3 mm in order to pass the endoscope. At nine months after emergent operation, gastric ESD was performed via only the gastrostoma. A hemoclip with thread was attached to the specimen, and the thread was pulled out of the gastrostoma. The specimen was able to be removed en bloc, resulting in radical resection. Gastric tube reconstruction through the posterior sternal route was performed at six months after the ESD. He has not developed recurrence of the esophageal or gastric cancer in the two years since the emergent operation. | Takuma Sasaki Masaya Uesato Takumi Ohta Kentarou Murakami Akira Nakano Hisahiro Matsubara | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，6： | 3 |
| 4 | 广州管圆线虫病所致嗜酸性细胞性脑膜脑炎18例临床分析显示文摘目的提高临床医师对广州管圆线虫病的认识. 方法分析18例广州管圆线虫病所致嗜酸粒细胞性脑膜脑炎的临床特征及实验室、流行病学调查资料. 结果发病前均有生食淡水螺肉史,潜伏期1-25天.以头痛、躯体痛为主要表现,头痛剧烈而脑膜刺激征不明显.周围血象、脑脊液中嗜酸粒细胞明显增高,血清广州管圆线虫抗体阳性(ELISA法).头颅CT正常,2例磁共振(MR)检查呈斑片状异常信号,脑电图α波变慢.用阿苯哒唑、氟美松治疗效果好,预后佳. 结论广州管圆线虫病是嗜酸粒细胞性脑膜脑炎的主要病因之一. | 王小同 黄汉津 董其谦 林燕 王宗敏 李方去 Yukifumi Nawa Kentars Yoshimura | 2002 | Chinese Medical Journal2002，，9： | 2 |
| 5 | Effects of Surface Roughness of Roll Metal Pins on Their Friction and Wear Characteristics 显示文摘 | Terumasa Hisakado Kentarou Miyazaki | 2000 | Wear2000，239，： | 1 |
| 6 | Endoscopic occlusion with silicone spigots for the closure of refractory esophago-bronchiole fistula after esophagectomy显示文摘A 65-year-old man with c T1 b N0M0 stage Ⅰ middle thoracic esophageal cancer underwent subtotal esophagectomy and gastric tube reconstruction through the posterior mediastinal route after preoperative carbon-ion radiotherapy and chemotherapy in a clinical trial. Anastomotic leakage occurred,but it spontaneously improved. At six months after the operation,he was rehospitalized with a cough and dysphagia. An esophago-bronchiole fistula and stenosis of the gastric tube were observed. He first underwent stent placement in the gastric tube. Two weeks later,the syringeal epithelium was burned by argon plasma coagulation after stent removal. Endoscopic occlusion was then performed for the fistula with two guidewire-assisted silicone spigots. Two weeks later,he was discharged on an oral diet,and he has not developed recurrence of the fistula or cancer for three years. This is the first report of endoscopic occlusion with a guidewire-assisted silicone spigot through the esophagus. | Masaya Uesato Tsuguaki Kono Yasunori Akutsu Kentarou Murakami Akiko Kagaya Yorihiko Muto Akira Nakano Mizuho Aikawa Tomohide Tamachi Hiroyuki Amagai Takahiro Arasawa Yasuhide Muto Hisahiro Matsubara | 2017 | World Journal of Gastroenterology2017，23，28： | 1 |
| 7 | The Effect of the Posterior Artificial Teeth Position on the Mobility of Lower Complete Dentures显示文摘 | Kentarou Mizuno Kenji Notani Takao Kawasald | 2001 | Jpn Prosthodont Soc2001，45，1： | 1 |
| 8 | Effects of surface roughness of roll metal pins on their friction and wear characteristics 显示文摘 | Terumasa Hisakado Kentarou Miyazaki | 2000 | Wear2000，239，1： | 1 |
| 9 | Analysis of Navigability of Web Applications for Improving Blind Usability 显示文摘 | Hironobu Takagi Shin Saito Kentarou Fukuda | 2007 | ACM Transac- tions on Computer-Human Interaction2007，14，3： | 1 |
| 10 | Evidence of spreading de- polarizations in a porcine cortical intracerebral hemorrhage model 显示文摘 | Orakeioglu B Uozurrd Y Kentar MM | 2012 | Aeta Neurochir Suppl2012，114，： | 1 |
| 11 | Carbon dioxide insufflation for colonoscopy: evaluation of gas volume, abdominal pain, examination time and transcutaneous partial CO2 pressure显示文摘 | Hiro-o Yamano Kenjirou Yoshikawa Tomoaki Kimura Eiichirou Yamamoto Eiji Harada Toyoki Kudou Ryusuke Katou Yasuko Hayashi Kentarou Satou | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 12 | Application of friction stir welding to construction of railway vehicles显示文摘 | Kawasaki Takeshi Makino Toshiaki Masai Kentarou | 2004 | SME Inter- national Joumal Series A Solid Mechanics and Material Engineering2004，47，3： | 1 |
| 13 | Vitrectomy combinede with phacoemulsification and intraocular lens implantation for diabetic macular edema显示文摘 | Kentar A Hidenobu T | 2002 | Jpn J Ophthalmol2002，46，： | 1 |
| 14 | Reinforcement learning for quasi-passive dynamic walking of an unstable biped robot显示文摘 | Kentarou Hitomi Tomohiro Shibata Yutaka Nakamura el al | 2006 | Robotics and Autonomous Systems2006，54，12： | 1 |
| 15 | Application of friction stir welding to construction of railway vehicles显示文摘 | Kawasaki Takeshi Makino Toshiaki Masai Kentarou | 2004 | JSME International Journal Series A: Solid Mechanics and Material Engineering2004，47，3： | 1 |
| 16 | Effect of Polymer density on polyethylene hollow fiber membrane formation via thermally induced phase separation 显示文摘 | Hideto Matsuyama Kentarou Hayashi Taisuke Maki | 2004 | Journal of Applied Polymer Science2004，93，1： | 1 |
| 17 | Effects of Quenching Conditions on Two-Step Aging Behavior of Al-Mg-Si Alloys显示文摘 | Yamada Kentarou Sato Tatsuo Kamio Akihiko | 2000 | 2000 (331)2000，，331： | 1 |
| 18 | Effects of ultrasonic waves on natural convection, nucleate boiling, and film boiling heat transfer from a wire to a saturated liquid 显示文摘 | YOSHIHIRO I KENTAROU T | 1992 | Experimental Thermal and Fluid Science1992，，5： | 1 |
| 19 | The Effect of the Posterior Artificial Teeth Position on the Mobility of Lower Complete Dentures显示文摘 | Kentarou Mizuno Kenji Notani Takao Kawasaki | 2001 | Jpn Prosthodont Soc2001，45，1： | 1 |
| 20 | Carbon dioxide insufflation for colonoscopy: evaluation of gas volume, abdominal pain, examination time and transcutaneous partial CO2 pressure显示文摘 | Hiro-o Yamano Kenjirou Yoshikawa Tomoaki Kimura Eiichirou Yamamoto Eiji Harada Toyoki Kudou Ryusuke Katou Yasuko Hayashi Kentarou Satou | 2010 | Journal of Gastroenterology2010，，12： | 1 |
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