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| 1 | Diabetic nephropathy in Africa:A systematic review显示文摘AIM:To determine the prevalence and incidence of diabetic nephropathy in Africa.METHODS:We performed a systematic narrative review of published literature following the MOOSE Guidelines for Meta-Analysis and Systematic Reviewsof Observational Studies.We searched Pub MedMEDLINE for all articles published in English and French languages between January 1994 and July 2014 using a predefined strategy based on the combination of relevant terms and the names of each of the 54 African countries and African sub-regions to capture the largest number of studies,and hand-searched the reference lists of retrieved articles.Included studies reported on the prevalence,incidence or determinants of chronic kidney disease(CKD) in people with diabetes within African countries.RESULTS:Overall,we included 32 studies from 16 countries;two being population-based studies and the remaining being clinic-based surveys.Most of the studies(90.6%) were conducted in urban settings.Methods for assessing and classifying CKD varied widely.Measurement of urine protein was the most common method of assessing kidney damage(62.5% of studies).The overall prevalence of CKD varied from 11% to 83.7%.Incident event rates were 94.9% for proteinuria at 10 years of follow-up,34.7% for endstage renal disease at 5 years of follow-up and 18.4% for mortality from nephropathy at 20 years of followup.Duration of diabetes,blood pressure,advancing age,obesity and glucose control were the common determinants of kidney disease.CONCLUSION:The burden of CKD is important among people with diabetes in Africa.High quality data from large population-based studies with validated measures of kidney function are still needed to better capture the magnitude and characteristics of diabetic nephropathy in Africa. | Jean Jacques N Noubiap Jashira Naidoo Andre P Kengne | 2015 | World Journal of Diabetes2015，6，5： | 3 |
| 2 | Pancreaticβ-cell dysfunction in type 2 diabetes:Implications of inflammation and oxidative stress显示文摘Insulin resistance and pancreaticβ-cell dysfunction are major pathological mechanisms implicated in the development and progression of type 2 diabetes(T2D).Beyond the detrimental effects of insulin resistance,inflammation and oxidative stress have emerged as critical features of T2D that defineβ-cell dysfunction.Predominant markers of inflammation such as C-reactive protein,tumor necrosis factor alpha,and interleukin-1βare consistently associated withβ-cell failure in preclinical models and in people with T2D.Similarly,important markers of oxidative stress,such as increased reactive oxygen species and depleted intracellular antioxidants,are consistent with pancreaticβ-cell damage in conditions of T2D.Such effects illustrate a pathological relationship between an abnormal inflammatory response and generation of oxidative stress during the progression of T2D.The current review explores preclinical and clinical research on the pathological implications of inflammation and oxidative stress during the development ofβ-cell dysfunction in T2D.Moreover,important molecular mechanisms and relevant biomarkers involved in this process are discussed to divulge a pathological link between inflammation and oxidative stress duringβ-cell failure in T2D.Underpinning the clinical relevance of the review,a systematic analysis of evidence from randomized controlled trials is covered,on the potential therapeutic effects of some commonly used antidiabetic agents in modulating inflammatory makers to improveβ-cell function. | Phiwayinkosi V Dludla Sihle E Mabhida Khanyisani Ziqubu Bongani B Nkambule Sithandiwe E Mazibuko-Mbeje Sidney Hanser Albert Kotze Basson Carmen Pheiffer Andre Pascal Kengne | 2023 | World Journal of Diabetes2023，14，3： | 2 |
| 3 | Incidence,Time and Deter- minants of Tuberculosis Treatment Default in Yaounde, Cameroon:A Retrospective HospilLal Register-Based Cohort Study显示文摘 | Pefura Yone E W Kengne A P | 2011 | BMJ Open2011，1，2： | 1 |
| 4 | Mild hyponatremia and risk of fracture in the ambulatory elderly显示文摘 | Gankam Kengne F Andres C Sattar L | 2008 | Quarterly Journal of Medicine2008，101，7： | 1 |
| 5 | Mild hyponatremia and risk of fracture in the ambulatory eld- erly 显示文摘 | Gankam Kengne F Andres C Sattar L | 2008 | QJM: Monthly Journal of the Association of Physicians2008，101，7： | 1 |
| 6 | Effect of high temperature during embryogenesis on the sex differentiation process in the Nile tilapia, Oreochromis niloticus 显示文摘 | Rougeot C Prignon C Kengne C V N | 2008 | Aquaculture2008，276，： | 1 |
| 7 | Trichomonas vaginalis:Repeated DNA target for highly sensitive and specific polymerase chain reaction diagnosis显示文摘 | Veas Francisco Vidal Nicole | 1994 | Cellular and Molecular Biology Noisy Le Grand1994，40，6： | 1 |
| 8 | Type 2 diabetes management in nurse-led primary healthcare settings in urban and rural Cameroon显示文摘 | Kengne A P Fezeu L Sobngwi E | 2009 | Primary care diabetes2009，3，3： | 1 |
| 9 | Cardiovascular Complications of Diabetes Mellitus in Sub-Saharan Africa显示文摘 | André Pascal Kengne Albert G.B. Amoah Jean-Claude Mbanya | 2005 | Circulation2005，，23： | 1 |
| 10 | Inappropriate secretion of ADH and central diabetes insipidus are related to antiphospholipid antibodies in SLE case report and review of the literature显示文摘 | Kengne FG Decaux G | 2006 | Nephrol Dial Transplant2006，21，11： | 1 |
| 11 | Mosquito development in a macrophyte-based wastewater treatment plant in Cameroon ( Central Africa) 显示文摘 | Kengne I M Brissaud F Akoa A | 2003 | Ecological Engineering2003，21，： | 1 |
| 12 | Trichomonas v哗inalis?? repeated DNA target for highly sensitive and specific polymerase chain reactiondiagnosis显示文摘 | Kengne P Veas F Vidal N | 1994 | Cell Mol Biol:Noisy-le-grand1994，40，6： | 1 |
| 13 | Mild hyponatremia and risk of frac- ture in the ambulatory elderly显示文摘 | Kengne FG Andres C Sattar L | 2008 | QJM2008，101，7： | 1 |
| 14 | Blood pressure variables and cardiovascular risk:new findings from ADVANCE显示文摘 | Kengne AP Czernichow S Huxley R | 2009 | Hypertension2009，54，2： | 1 |
| 15 | Prediction models for the risk of cardiovascular disease in patients with type 2 diabetes: a systematic review显示文摘 | VAN DIEREN S BEULENSJ W KENGNE A P | 2012 | Heart2012，98，5： | 1 |
| 16 | The ADVANCE cardiovascular risk model and current strategies for cardiovascular disease risk evaluation in people with diabetes显示文摘 | KENGNE A P | 2013 | CardiovascJ Afr2013，24，910： | 1 |
| 17 | The efficacy of lowering glycated haemoglobin with a gliclazide modified release-based intensive glucose lowering regimen in the ADVANCE trial显示文摘 | Zoungas S Chalmers J Kengne AP | 2010 | Diabetes Res Clin Pract2010，89，2： | 1 |
| 18 | Gamma-glutamyl- transferase and risk of cardiovascular disease mortality in people with and without diabetes : pooling of three British Health Surveys 显示文摘 | Kengne A P Czernichow S Stamatakis E | 2012 | J Hepatol2012，57，5： | 1 |
| 19 | Contemporary model for cardiovascular risk prediction in people with type 2 diabetes显示文摘 | KENGNE A P PATEL A MARRE M | 2011 | EurJ Cardiovasc Prev Rehabil2011，18，3： | 1 |
| 20 | The Framingham and UK Prospective Diabetes Study (UKPDS) risk equations do not reliably estimate the probability of cardiovascular events in a large ethnical- ly diverse sample of patients with diabetes: the Action in Diabetes and Vascular Disease: Preterax and Diamicron-MR Controlled E- valuation (ADVANCE) Study 显示文摘 | Kengne AP Patel A Colagiuri S | 2010 | Diabetologia2010，53，5： | 1 |
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