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| 1 | Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by α-lipoic acid in humans显示文摘AIM: To evaluate the protective effects of precondition- ing by α-lipoic acid (LA) in patients undergoing hepatic resection under inflow occlusion of the liver. METHODS: Twenty-four patients undergoing liver re- section for various reasons either received 600 mg LA or NaCl 15 min before transection performed under inflow occlusion of the liver. Blood samples and liver wedge bi- opsy samples were obtained after opening of the abdo- men immediately after inflow occlusion of the liver, and 30 min after the end of inflow occlusion of the liver. RESULTS: Serum levels of aspartate transferase and alanine transferase were reduced at all time points in patients who received LA in comparison to those who received NaCL. This was accompanied by reduced histo- morphological features of oncosis. We observed TUNEL- positive hepatocytes in the livers of the untreated patients, especially after 30 min of ischemia. LA attenu- ated this increase of TUNEL-positive hepatocytes. Under preconditioning with LA, ATP content was significantly enhanced after 30 min of ischemia and after 30 min of reperfusion. CONCLUSION: This is the first report on the poten- tial for LA reducing ischemia/reperfusion injury (IRI) of the liver in humans who were undergoing liver surgery. Beside its simple and rapid application, side effects did not occur. LA might therefore represent a new strategy against hepatic IRI in humans. | Fritz Dünschede Kirsten Erbes Achim Kircher Stefanie Westermann Joachim Seifert Arno Schad Kempski Oliver Alexandra K Kiemer Junginger Theodor | 2006 | World Journal of Gastroenterology2006，12，42： | 6 |
| 2 | Spreading depression and focal venous cerebral ischemia enhance cortical neurogenesis显示文摘Endogenous neurogenesis can arise from a variety of physiological stimuli including exercise, learning, or 'enriched environment' as well as pathological conditions such as ischemia, epilepsy or cortical spreading depression. Whether all these conditions use a common trigger to set off endogenous neurogenesis is yet unclear. We hypothesized that cortical spreading depression(CSD) induces neurogenesis in the cerebral cortex and dentate gyrus after cerebral venous ischemia. Forty-two Wistar rats alternatively underwent sham operation(Sham), induction of ten CSDs or venous ischemia provoked via occlusion of two adjacent superficial cortical vein followed by ten induced CSDs(CSD + 2-VO). As an additional control, 15 na?ve rats received no intervention except 5-bromo-2′-deoxyuridine(Brd U) treatment for 7 days. Sagittal brain slices(40 μm thick) were co-stained for Brd U and doublecortin(DCX; new immature neuronal cells) on day 9 or Neu N(new mature neuronal cells) on day 28. On day 9 after sham operation, cell proliferation and neurogenesis occurred in the cortex in rats. The sole induction of CSD had no effect. But on days 9 and 28, more proliferating cells and newly formed neurons in the ipsilateral cortex were observed in rats subjected to CSD + 2VO than in rats subjected to sham operation. On days 9 and 28, cell proliferation and neurogenesis in the ipsilateral dentate gyrus was increased in sham-operated rats than in na?ve rats. Our data supports the hypothesis that induced cortical neurogenesis after CSD + 2-VO is a direct effect of ischemia, rather than of CSD alone. | Ryo Tamaki Samuel Ige Orie Beat Alessandri Oliver Kempski Axel Heimann | 2017 | Neural Regeneration Research2017，12，8： | 3 |
| 3 | Cerebral edema 显示文摘 | Kempski O | 2001 | Semin Nephrol2001，21，3： | 2 |
| 4 | Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia in the UK:A population-based study of incidence and survival显示文摘 | Passmore SJ Chessells JM Kempski H | 2003 | Br J Haematol2003，121，5： | 1 |
| 5 | Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia 显示文摘 | Jacobs T P Kempski O Mckinley D | 1992 | Stroke1992，23，3： | 1 |
| 6 | Cerebral edema 显示文摘 | Kempski O | 2001 | Sermin-Nephrol2001，21，3： | 1 |
| 7 | Blood flow andvascular permeability during motor dysfunction in a rabbitmodel of spinal cord ischemia 显示文摘 | Jacbs TP Kempski O McKinley D et at | 1992 | Stroke1992，23，3： | 1 |
| 8 | Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia 显示文摘 | Jacobs TP Kempski O McKinley D | 1992 | Stroke1992，23，3： | 1 |
| 9 | Spreading depression induces permanent cell swelling under penumbra conditions显示文摘 | Kempski O Otsuka H Seiwert T | 2000 | Acta Neurochir Suppl2000，76，： | 1 |
| 10 | Hypertonic saline and stroke 显示文摘 | Kempski O | 2005 | Crit Care Med2005，33，： | 1 |
| 11 | Cerebral blood flow alterations in a rat model of cerebral sinus thrombosis显示文摘 | Ungersbock K Heimann A Kempski O | 1993 | Stroke1993，24，4： | 1 |
| 12 | Cerebral sinus and venous thrombosis in rats induces long term deficits in brain function and morphology evidence for a cytotoxic genesis显示文摘 | Frerichs KU Deckert M Kempski O | 1994 | J Cerb Blood Flow Metab1994，14，2： | 1 |
| 13 | Inhibition of lactate export by quercetin acidifies rat glial cells in vitro显示文摘 | Kempski B Kempski OS | 1997 | Neurosci Lett1997，223，2： | 1 |
| 14 | Local cerebral blood flow in a rat cortical vein occlusion model 显示文摘 | Nakase H Heimann A Kempski O | 1996 | Cereb Blood Flow Metab1996，16，4： | 1 |
| 15 | Microcirculatory alterations in a Mongolian gerbil sinus-vein thrombosis model显示文摘 | Miyamoto K Heimann A Kempski O | 2001 | J Clin Neurosci2001，8，1： | 1 |
| 16 | Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia in the UK: a population-based study of incidence and survival显示文摘 | Passmore SJ Chessells JM Kempski H | 2003 | Br J Haematol2003，121，5： | 1 |
| 17 | Microcirculatory alteration in a Mongolian gerbil sinus-vein thrombosis model显示文摘 | Heimann A Kempski O | 2001 | J Clin Neurosci2001，8，1： | 1 |
| 18 | Statistical approach to discharge bearing currents显示文摘 | Robert Smolenski Adam Kempski Jacek Bojarski | 2010 | COMPEL: The International Journal for Computation and Mathematics in Electrical and Electronic Engineering2010，，3： | 1 |
| 19 | Microsirculation after cerebral venous occlusions as assessed by laser Doppler scanning显示文摘 | Kempski OS Heimann A | 1997 | J Neurosurg1997，87，2： | 1 |
| 20 | Cerebral edema显示文摘 | Kempski O | 2001 | Semin-Nephrol2001，21，3： | 1 |
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