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| 1 | Effect of thrombectomy on oedema progression and clinical outcome in patients with a poor collateral profile显示文摘Background and purpose The impact of the cerebral collateral circulation on lesion progression and clinical outcome in ischaemic stroke is well established.Moreover,collateral status modifies the effect of endovascular treatment and was therefore used to select patients for therapy in prior trials.The purpose of this study was to quantify the effect of vessel recanalisation on lesion pathophysiology and clinical outcome in patients with a poor collateral profile.Materials and methods 129 patients who had an ischaemic stroke with large vessel occlusion in the anterior circulation and a collateral score(CS)of 0-2 were included.Collateral profile was defined using an established 5-point scoring system in CT angiography.Lesion progression was determined using quantitative lesion water uptake measurements on admission and follow-up CT(FCT),and clinical outcome was assessed using modified Rankin Scale(mRS)scores after 90 days.Results Oedema formation in FCT was significantly lower in patients with vessel recanalisation compared with patients with persistent vessel occlusion(mean 19.5%,95%CI:17%to 22%vs mean 27%,95%CI:25%to 29%;p<0.0001).In a multivariable linear regression analysis,vessel recanalisation was significantly associated with oedema formation in FCT(ß=−7.31,SD=0.015,p<0.0001),adjusted for CS,age and Alberta Stroke Program Early CT Score(ASPECTS).Functional outcome was significantly better in patients following successful recanalisation(mRS at day 90:4.5,IQR:2-6 vs 5,IQR:5-6,p<0.001).Conclusion Although poor collaterals are known to be associated with poor outcome,endovascular recanalisation was still associated with significant oedema reduction and comparably better outcome in this patient group.Patients with poor collaterals should not generally be excluded from thrombectomy. | Gabriel Broocks Andre Kemmling Tobias Faizy Rosalie McDonough Noel Van Horn Matthias Bechstein Lukas Meyer Gerhard Schon Jawed Nawabi Jens Fiehler Helge Kniep Uta Hanning | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 2 | Collateral Vessels on CT Angiography Predict Outcome in Acute Ischemic Stroke显示文摘 | Matthew B. Maas Michael H. Lev Hakan Ay Aneesh B. Singhal David M. Greer Wade S. Smith Gordon J. Harris Elkan Halpern André Kemmling Walter J. Koroshetz Karen L. Furie | 2009 | Stroke2009，，9： | 1 |
| 3 | Dysphagia in patients with acute striatocapsular hemorrhage显示文摘 | Suntrup S Warnecke T Kemmling A | 2012 | J Neurol2012，259，1： | 1 |
| 4 | Serum tau protein Level as a marker of axonal damage in acute isehemic stroke 显示文摘 | Bitsch A Horn C Kemmling Y | 2002 | Eur Neurol2002，47，： | 1 |
| 5 | Hos- pital acquired pneumonia is linked to right hemispheric peri-insular stroke显示文摘 | KEMMLING A LEV M H PAYABVASH S | 2013 | PLoS One2013，8，8： | 1 |
| 6 | Variable selection and prediction using a nested,matched case-control study:application to hospital acquired pneumonia in stroke patients显示文摘 | Qian J Payabvash S Kemmling A | 2014 | Biometrics2014，70，1： | 1 |
| 7 | Serum tau protein level as a marker of axonal damage in acute ischemic stroke显示文摘 | Bitsch A Horn C Kemmling Y | 2002 | Eur Neurol2002，47，： | 1 |
| 8 | Case report of MR perfusion imaging in sinking skin flap syndrome:growingevidence for hemodynamic impairment显示文摘 | Kemmling A Duning T Lemcke L | 2010 | BMC Neurology2010，，10： | 1 |
| 9 | Spontaneous recanalization of occluded standard extracranial-intracranial arterial bypass 显示文摘 | Scharf J Kemmling A Gerigk L | 2007 | Cerebrovasc Dis2007，23，23： | 1 |
| 10 | Hospital ac-quired pneumonia is linked to right hemispheric peri-insular stroke显示文摘 | Kemmling A Lev MH Payabvash S | | 0，，8： | 1 |
| 11 | Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice显示文摘 | Diaz SL Kemmling AK Rubio MC | 2001 | Behav Pharmacol2001，12，1： | 1 |
| 12 | Baclofen pre-vents morphine withdrawal irrespective of seasonal vari-ation显示文摘 | Kemmling AK Rubio MC Balerio GN | 2002 | Behav Pharmacol2002，13，1： | 1 |
| 13 | Serum tau protein le~,el as a marker of axonal damage in acute ischemic stroke 显示文摘 | Bitsch A Horn C Kemmling Y | 2002 | Eur Neurol2002，47，1： | 1 |
| 14 | Morphine withdrawal syndrome: involvement of the dopaminergic system in prepubertal male and female mice显示文摘 | Diaz SL Kemmling AK Rubio MC Balerio GN | 2005 | Pharmacol Biochem Behav2005，82，4： | 1 |
| 15 | A diagnostic pitfallfor intracranial aneurysms in time-of-flight MR angiography:small intracranial lipomas显示文摘 | Kemmling A Noelte I Gerigk L | 2008 | Am J Roentgenol2008，190，1： | 1 |
| 16 | Reperfusion by combined thrombolysis and mechanical thrombectomy in acute stroke:effect of collateralization,mismatch,and time to and grade of recanalization on clinical and tissue outcome显示文摘 | Hesselmann V Niederstadt T Dziewas R Ritter M Kemmling A Maintz D | | 0，，： | 1 |
| 17 | Serum tau protein Level as a marker of axonal damage in acute ischemic stroke 显示文摘 | Bitsch A Hom C Kemmling Y | 2002 | Eur Neurol2002，47，： | 1 |
| 18 | CTP-Based tissue outcome: promising tool to prove the beneficial effect of mechanical recanalization in acute ischemic stroke 显示文摘 | Drewer-Gutland F Kemmling A Ligges S | 2015 | Europe PMC2015，187，6： | 1 |
| 19 | Serum Tau protein level as a marker of axonal damage in acute ischemic stroke显示文摘 | Bitsch A Horn C Kemmling Y | 2002 | Eur Neurol2002，47，1： | 1 |
| 20 | Current issues and perspec- tives in small rodent magnetic resonance imaging using clinical MRI scanners 显示文摘 | Brockmann MA Kemmling A Groden C | 2007 | Methods2007，43，1： | 1 |
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