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| 1 | Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study)显示文摘AIM: To establish which scolicidal agents are superiorand more suitable for regular use.METHODS: Echinococcus granulosus protoscoleceswere obtained from 25 patients with liver hydatidcysts. Various concentrations of albendazole sulfone,albendazole sulfoxide, and albendazole sulfone andalbendazole sulfoxide mixed together in concentrationsof 50 μg/mL, and H2O2 in a concentration of 4%, NaCl20%, and 1.5% cetrimide-0.15% chlorhexidine (10%Savlon-Turkey) were used to determine the scolicidaleffects. Albendazole (ABZ) derivatives and otherscolicidal agents were applied to a minimum of 100scoleces for 5 and 10 min. The degree of viability wascalculated according to the number of living scolicesper fi eld from a total of 100 scolices observed underthe microscope.RESULTS: After 5 min, ABZ sulfone was 97.3%effective, ABZ sulfoxide was 98.4% effective, and thecombined solution was 98.6% effective. When sulfone,sulfoxide and the combined solutions were compared,the combined solution seemed more effective thansulfone. However, there was no difference when thecombined solution was compared with sulfoxide. After10 min, hypertonic salt water, sulfone, sulfoxide, andthe combined solution compared to other solutionslooked more effective and this was statisticallysignificant on an advanced level. When sulfone,sulfoxide, and the combined solutions were compared with each other, the combined solution appeared more effective than sulfone. When the combined solution was compared with sulfoxide, there was no difference.CONCLUSION: Despite being active, ABZ metabolites did not provide a marked advantage over 20% hypertonic saline. According to these results, we think creating a newly improved and more active preparation is necessary for hydatid cyst treatment. | Gokhan Adas Soykan Arikan Ozgur Kemik Ali Oner Nilgun Sahip Oguzhan Karatepe | 2009 | World Journal of Gastroenterology2009，15，1： | 19 |
| 2 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 3 | Effects of glutamine and curcumin on bacterial translocation in jaundiced rats显示文摘AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice. | Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 4 | The relationship among acute-phase response proteins,cytokines and hormones in cachectic patients with colon cancer显示文摘 | Kemik O Sumer A Kemik AS | 2010 | World J Surg Oncol2010，8，： | 1 |
| 5 | Metabolic and inflam- matory responses after ERCP显示文摘 | Adas G Kemik A Adas M | 2013 | Int J Biomed Sci2013，9，4： | 1 |
| 6 | Outcome of surgical treatment of intestinal perforation in typhoid fever显示文摘AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively.RESULTS:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or constipation.Sixteen cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair following debridement,one case with multiple perforations received 2-layered primary repair and end ileostomy,one case received segmental resection and end-to-end anastomosis followed by an end ileostomy,and one case received segmental resection and end ileostomy with mucous fistula operation.Postoperative morbidity was seen in 5 cases and mortality was found in one case.CONCLUSION:Intestinal perforation resulting from Salmonella typhi is an important health problem in Eastern and Southeastern Turkey.In management of this illness,early and appropriate surgical intervention is vital. | Aziz Sümer zgür Kemik Ahmet Cumhur Dülger Aydemir Olmez Ismail Hasirci Erol Kisli Vedat Bayrak Gulay Bulut etin Kotan | 2010 | World Journal of Gastroenterology2010，16，33： | 1 |
| 7 | The association between serum Dickkopf-1 levels and esophageal squamous cell carcinoma显示文摘 | Begenik H Kemik A Emre H | 2014 | Hum Exp Toxicol2014，33，8： | 1 |
| 8 | Increase in the circulating level of hepatocyte growth factor in pancreatic cancer patients 显示文摘 | Kemik O Purisa S Kemik AS | 2009 | Bratisl Lek Listy2009，110，10： | 1 |
| 9 | Serum thymidine kinase is associated with gastric adenocarcinoma显示文摘 | Kemik O Kemik AS Purisa S | | 0，，09： | 1 |
| 10 | Use of alhendazole sulloxide, albendazole sulfone, and combined solutions as seoliciclal agents on hydatid cysts (in vitro study)显示文摘 | Adas G Arikan S Kemik O | 2009 | World J Gastroenterol2009，15，： | 1 |
| 11 | Alpha-1 proteaseinhibitor and antichymotrypsin levels in acute pancreatitis显示文摘 | Karsidag T Tüzün S Kemik AS | 2012 | Ulus Travma Acil Cerrahi Derg2012，18，3： | 1 |
| 12 | Circulating levels of VEGF family and their receptors in hepatocellular carcinoma显示文摘 | Kemik O Sumer A Kemik S A | | 0，，09： | 1 |
| 13 | A novel screening test for colon cancer:Talin-1显示文摘 | Bostanci O Kemik O Kemik A | 2014 | Eur Rev Med Pharmacol Sci2014，18，： | 1 |
| 14 | Outcome of surgicaltreatmentofintestinal perforationintyphoidfever显示文摘 | Siimer A Kemik O Dalger AC | 2010 | world J Gastroenterol2010，16，33： | 1 |
| 15 | The Removal ofHeavy Metal Ions from Aqueous Solutions by NovelpH-Sensitive Hydrogels 显示文摘 | Yildiz U Kemik O F Hazer B | 2010 | Journal of HazardousMaterials2010，183，123： | 1 |
| 16 | Serum YKL- 40 Levels in Patients with Gastric Cancer 显示文摘 | Itik V Kemik O Kemik A | 2011 | Biomark Cancer2011，，3： | 1 |
| 17 | Lipopolysaccharide activates nuclear factor κB in rat intestine:role of endogenous platelet-activating factor and tumour necrosis factor 显示文摘 | De Plaen IG Tan XD Chang H Wang L Kemik DG Hsueh W | 2000 | BrJ Pharrnacol2000，129，2： | 1 |
| 18 | Serum thymidine ki nase is associated with gastric adenocarcinoma 显示文摘 | Kemik O Kemik A S Purisa S | 2011 | Bratisl Lek Listy2011，112，9： | 1 |
| 19 | The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer 显示文摘 | Kemik 0 Sumer A Kemik AS | 2010 | World J Surg Oncol2010，8，1： | 1 |
| 20 | Role of serum my- eloperoxidase, CPK, CK - MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP显示文摘 | Yildiz K Ince AT Sarbay Kemik A | 2014 | Turk J Gastroenterol2014，25，3： | 1 |
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