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| 1 | Nanozymes: created by learning from nature显示文摘Nanozymes,a type of nanomaterials with enzyme-like activity,have shown great potential to replace natural enzymes in many fields such as biochemical detection,environmental management and disease treatment.However,the catalytic efficiency and substrate specificity of nanozymes still need improvement.To further optimize the enzymatic properties of nanozymes,recent studies have introduced the structural characteristics of natural enzymes into the rational design of nanozymes,either by employing small molecules to mimic the cofactors of natural enzymes to boost nanozymes’catalytic potential,or by simulating the active center of natural enzymes to construct the nanostructure of nanozymes.This review introduces the commonly used bio-inspired strategies to create nanozymes,aiming at clarifying the current progress and bottlenecks.Advances and challenges focusing on the research of bio-inspired nanozymes are outlined to provide ideas for the de novo design of ideal nanozymes. | Ruofei Zhang Kelong Fan Xiyun Yan | 2020 | Science China(Life Sciences)2020，63，8： | 13 |
| 2 | Temperature variability since A.D.1837 inferred from tree-ring maximum density of Abies fabri on Gongga Mountain,China显示文摘Two tree-ring MXD (maximum latewood density) chronologies of Abies fabri were developed from the eastern slopes of Gongga Mountain, and a regional chronology (RC) was established based on the two MXD chronologies. There were significant positive correlations between the three MXD chronologies and August-September temperature, and the RC had the highest correlation (r=0.733, n=48, P<0.001) with mean August-September temperature. Based on growth-climate analyses, we reconstructed mean August-September temperature during the past 171 years for the study area. The reconstruction explained 53.5% of the instrumental temperature variance during the period 1960-2007 (F=52.8, R2adj =52.4%). In the past 171 years, there were 22 very warm years and 23 very cold years, four cold periods (1837-1842, 1884-1891, 1899-1905 and 1984-1989) and three warm periods (1966-1973, 1916-1924 and 1876-1881). Our reconstruction was validated by other tree ring-based temperature reconstructions from the surrounding area and documented climate disaster events. | DUAN JianPing WANG Lily LI Lun CHEN KeLong | 2010 | Chinese Science Bulletin2010，55，26： | 11 |
| 3 | Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries显示文摘Interventional coronary reperfusion strategies are widely adopted to treat acute myocardial infarction,but morbidity and mortality of acute myocardial infarction are still high.Reperfusion injuries are inevitable due to the generation of reactive oxygen species(ROS)and apoptosis of cardiac muscle cells.However,many antioxidant and anti-inflammatory drugs are largely limited by pharmacokinetics and route of administration,such as short half-life,low stability,low bioavailability,and side effects for treatment myocardial ischemia reperfusion injury.Therefore,it is necessary to develop effective drugs and technologies to address this issue.Fortunately,nanotherapies have demonstrated great opportunities for treating myocardial ischemia reperfusion injury.Compared with traditional drugs,nanodrugs can effectively increase the therapeutic effect and reduces side effects by improving pharmacokinetic and pharmacodynamic properties due to nanodrugs’size,shape,and material characteristics.In this review,the biology of ROS and molecular mechanisms of myocardial ischemia reperfusion injury are discussed.Furthermore,we summarized the applications of ROS-based nanoparticles,highlighting the latest achievements of nanotechnology researches for the treatment of myocardial ischemia reperfusion injury. | Tianjiao Zhao Wei Wu Lihua Sui Qiong Huang Yayun Nan Jianhua Liu Kelong Ai | 2022 | Bioactive Materials2022，7，1： | 11 |
| 4 | Quantification of trace amounts of impurities in high purity cobalt by high resolution inductively coupled plasma mass spectrometry显示文摘An analytical method using high resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) for rapid simultaneous determination of 24 elements (Be, Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Ge, As, Se, Mo, Ag, Cd, Sn, Sb, Ba, Pt, Au, and Pb) in high purity cobalt was described. Sample digestions were performed in closed microwave vessels using HNO3 and HCl. The matrix effects because of the presence of excess HCl and Co were evaluated. The usefulness of high mass resolution for overcoming some spectral interference was demonstrated. The optimum conditions for the deter- mination were tested and discussed. The standard addition method was employed for quantitative analysis. The detection limits were 0.016-1.50 μg?g?1, the recovery ratios were 92.2%-111.2%, and the RSD was less than 3.6%. The method was accurate, quick, and convenient. It was applied to the determination of trace impurities in high purity cobalt with satisfactory results. | XIE Hualin HUANG Kelong NIE Xidu TANG Yougen | 2007 | Rare Metals2007，26，3： | 10 |
| 5 | Transition metal-nitrogen-carbon nanostructured catalysts for the oxygen reduction reaction: From mechanistic insights to structural optimization显示文摘在阴极加速限制率的氧减小反应(ORR ) 为燃料房间的商品化仍然是最前的问题。转变 metal-nitrogen-carbon (M-N/C, M = Fe,公司,等等) nanostructures 在实际燃料房间应用与令人满意的活动和稳定性是非宝贵的金属催化剂(NPMC ) 的最有希望的班。然而,活跃地点的长争论的性质并且逃犯结构表演关联阻碍 M-N/C 材料的进一步的开发。在这评论,我们阐明的现在的最近的努力由采用可以提供 M-N/C 催化剂的深刻机械学的理解的许多物理化学的技术的活跃地点的实际结构。然后,我们为控制结构的一致性并且在催化材料最大化活跃地点的数字与定制的先锋体系结构和修改合成线路为 M-N/C 材料在结构的优化策略集中于惊人进步。恰好活跃的中心的识别和 nanostructures 的地点特定的工程为设计有益的 M-N/C 催化剂提供未来方向。 | Mengxia Shen Changting Wei Kelong Ai Lehui Lu | 2017 | Nano Research2017，10，5： | 8 |
| 6 | Nanozymes Inspired by Natural Enzymes显示文摘CONSPECTUS:Nanozymes,nanomaterials with enzyme-like activities with high structural stability,adjustable catalytic activity,functional diversity,recyclability,and feasibility in large-scale preparation,have become a hot spot in the field of artificial enzymes in recent years and are expected to become potential surrogates and competitors for natural enzymes in practical applications.With the development of in-depth research and a wide range of application requirements,creating nanozymes with catalytic performance comparable to or even surpassing that of natural enzymes has been the key research topic in this field.Most of the nanozymes reported in the past were obtained based on random synthesis and screening,for which the catalytic efficiency is far inferior to that of natural enzymes.Natural enzymes that have evolved over hundreds of millions of years have developed a lot of high-efficiency catalysis know-how hidden in their structural features.To create highly active nanozymes,we assumed that there is a general structure−activity relationship between nanozymes and natural enzymes and proposed the nanozyme optimization strategy by grafting the catalytic principles of natural enzymes into the rational design of nanozymes.On the basis of this bioinspired strategy,a series of nanozymes that exhibit similar catalytic activities that are closer to or even beyond those of natural enzymes have been successfully synthesized.By now,rationally designed high-activity bioinspired nanozymes have become a hot topic in the current research on nanozymes.In this Account,we focus on recent representative research progress in the systemic design and construction of bioinspired nanozymes and are devoted to introducing strategic concepts in the bioinspired optimization of nanozymes.We show that the de novo design of nanozymes by simulating the amino acid microenvironment and using metal-free architecture and the coordination structure of metal active sites in natural enzymes is an effective strategy for significantly improving the catalytic performance of nanozymes.A future perspective of the challenges and countermeasures of bioinspired nanozymes is proposed on the basis of these achievements.We hope that the biologically inspired perception will arouse widespread interest in fundamental research and practical applications as well as provide inspiration for the rational design of nanozymes. | Ruofei Zhang Xiyun Yan Kelong Fan | 2021 | Accounts of Materials Research2021，2，7： | 8 |
| 7 | Nanozymes: an emerging field bridging nanotechnology and enzymology显示文摘Nanozyme,a class of nanomaterials with intrinsic enzymelike properties,is a new concept which has been included in the Encyclopedia of China and the textbook of enzyme engineering.Since the first evidence published in 2007(Gao et al.,2007),great progress has been achieved in the study of nanozyme from new concept,new material to its new application,and it becomes an emerging field bridging nanotechnology and biology(Gao and Yan,2016). | Xiangqin Meng Kelong Fan Xiyun Yan | 2019 | Science China(Life Sciences)2019，62，11： | 8 |
| 8 | Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics显示文摘Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics;however,fabricating adhesive hydrogels with multiple functions remains a challenge.In this study,a mussel-inspired tannic acid chelated-Ag(TA-Ag)nanozyme with peroxidase(POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles(NPs)with TA.The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid.The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone,providing the hydrogels with long-term and repeatable adhesiveness,similar to the adhesion of mussels.The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network,thereby improving its mechanical properties and conductivity.Furthermore,the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag.Owing to these advantages,the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive,antibacterial,and implantable bioelectrode to detect bio-signals,and as a wound dressing to accelerate tissue regeneration while preventing infection.Therefore,this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis. | Zhanrong Jia Xuanhan Lv Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu | 2021 | Bioactive Materials2021，6，9： | 7 |
| 9 | Fluorescence enhancement and cofluorescence in complexes of terbium(III) with trimellitic acid显示文摘The fluorescence of terbium (III) was enhanced by about three orders of magnitude in the presence of trimellitic acid (benzene-1, 2, 4-tricarboxylic acid (TLA)) in aqueous solution at pH 6. The fluorescence intensity could be greatly in- creased when the system of Tb3+-TLA was treated with La3+ (or Gd3+) and TritonX-100. The addition of La3+ (or Gd3+) en- hances the fluorescence of the system by about two orders of magnitude due to cofluorescence, and the TritonX-100 micel- lar medium plays an important role for stabilization of the system. Both the intermolecular energy transfer mode and in- tramolecular energy transfer mode are responsible for the mechanism of fluorescence enhancement. In the optimum condi- tions, the fluorescence intensity is a linear function of Tb3+ concentration in the range of 7.8 × 10?9-3.6 × 10?6 mol/L for the system Tb3+-La3+-TLA and 1.0 × 10?8-4.7 × 10?6 mol/L for the system Tb3+-Gd3+-TLA, and the limits of detection are 4.6 × 10?10 mol/L and 6.0 × 10?10 mol/L, respectively. | ZHAO Xuehui HUANG Kelong JIAO Feipeng LI Zhiaojian PENG Xiahui | 2006 | Rare Metals2006，25，2： | 4 |
| 10 | Analysis of ecological effects of comprehensive treatment in the Tarim River Basin using remote sensing data显示文摘Based on multi-type,multi-temporal remote sensing data,we have monitored recent changes in cultivated land use and vegetation,in sandy areas and salinized desertification in the Green Corridor zone of the main channel of the Tarim River Basin.The results of our investigation show that the ecological environment in the Green Corridor of the main channel of the Tarim River Basin has conspicuously improved from 2002 to 2004.These improvements show up largely in such aspects as an increase in the rate of vegetation cover,a reduction in desertification land areas and a weakening in the intensity of sandy and the salinized land.On the other hand,the cultivated area in the Tarim River Basin significantly increased from 2002 to 2004.The rate of growth in cultivated areas during this period was significantly higher than that from 1999 to 2002.The increase in the use of irrigation resulting from the substantial increase in cultivated areas has a long-term potential restraining effect on the restoration of ecological functions of the Tarim River. | Tan Kelong Wang Xiaofeng Gao Huijun | 2011 | Mining Science and Technology2011，21，4： | 4 |
| 11 | Preparation and electrochemical performance of spherical Fe_3O_4 as anode materials for Li-ion batteries显示文摘Fe3O4 nano-powder was prepared by the hydrothermal method. The structure and morphology of the product were characterized by X-ray diffraction (XRD) and scanning electronic microscopy (SEM). The as-prepared powder has regularly spherical morphology, and the average size of product is about 25 nm. The possible application use of this material as the active mass of anode for rechargeable Li batteries was examined by cyclic voltammeter (CV), galvanostatic charge/discharge.The experimental results showed that this material exhibited large specific capacity at the first cycle, and the discharge and charge capacity retention of this electrode are 37.04% and 48.76%, respectively. Furthermore, the impedance change of Fe3O4 electrode under different cycle number and potential was examined. | WANG FangBin, CHEN Jie, HUANG KeLong & LIU SuQin College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, China | 2009 | Science China(Technological Sciences)2009，52，11： | 3 |
| 12 | Thermal Behavior Investigation of LiNi1/3CO1/3Mn1/3O2-Based Li-ion Battery under Overcharged Test显示文摘它象隔板,电解质,阴极,阳极,和每个文件夹那样的部件的热行为被微分扫描热量测定和热 gravimetric (DSC/TG ) 调查在超载测试下面解释 Li 离子电池的热逃走的机制。DSC 结果显示了在阳极的层在大约 126 漠 ? 桴 ? 潢瑴敬的 SEI (稳固的电解质接口) 的分解反应温度吗? | Wang, Haiyan Tang, Aidong Huang, Kelong | 2011 | Chinese Journal of Chemistry2011，29，1： | 3 |
| 13 | Development history and prospect of remote sensing technology in coal geology of China显示文摘Coal remote sensing technology was founded in the period of coal resources survey after the founding of People’s Republic of China.Aerophoto Grammetry&Remote Sensing Bureau of China National Administration of Coal Geology was established,specializing in the application and promotion of coal remote sensing technology.With the rapid development of coal geological exploration in China,coal remote sensing technology has evolved from coal geology based survey to comprehensive survey that factors in resources,environment,ecology and so on.This paper summarizes the general situation,theories,development process,key research and future of remote sensing technology for coal mining in China.Spanning over 50 years,the history of China’s coal remote sensing technology can be divided into five stages:aero-geological mapping,coal remote sensing theory experimental research,application research and promotion,architecture planning and productionisation,“3S”technology integration and application.This paper expounds the main technical progress,application fields,major projects and major achievements in various historical periods,and points out that the coal remote sensing has entered a unified development stage of“Aviation,Aerospace and Ground”,with a focus on high-resolution remote sensing,hyperspectral remote sensing,radar remote sensing,“3S”technology integration and multi-means comprehensive exploration and evaluation.In the future,coal remote sensing technology will develop rapidly in data mass,technology integration,evaluation intelligence,integration application programming,system visualization,etc.Coal remote sensing technology has entered the industrial development from technology application. | Kelong Tan Junwei Qiao | 2020 | International Journal of Coal Science & Technology2020，7，2： | 3 |
| 14 | Study on the lift and propulsive force shares to improve the flight performance of a compound helicopter显示文摘To investigate the effects of lift and propulsive force shares on flight performance,a compound helicopter model is derived.The model consists of a helicopter model,a wing model and a propeller model.At a low speed of 100 km/h,the Lift-to-Drag ratio(L/D)of the compound helicopter is improved when the wing provides 20.2%of the take-off weight.At high speeds,the L/D can be improved when the propeller provides the total propulsive force.Lowering the main rotor speed increases the wing lift share,however,the maximum L/D increases first and then decreases.The maximum L/D increases with decreasing the blade twist of the main rotor.Decreasing the blade twist from-16°to-8°increases the maximum L/D by 2.3%,and the wing lift share is increased from 65.0%to 74.7%.When the main rotor torque is balanced by the rudder,the maximum L/D is increased by 2.2%without changing the wing lift share.The wing should provide more lift as increasing the take-off weight,which reduces the induced power of the main rotor and increases the L/D.When increasing the take-off weight from 9500 kg to 11000 kg,the maximum L/D is increased by 6.5%,and the wing lift share is increased from 74.7%to 80.2%. | Kelong YANG Dong HAN Qipeng SHI | 2022 | Chinese Journal of Aeronautics2022，35，1： | 2 |
| 15 | Effect of organic additives on positive electrolyte for vanadium redox battery显示文摘 | Sha Li Kelong Huang Suqin Liu Dong Fang Xiongwei Wu Dan Lu Tao Wu | 2011 | Electrochimica Acta2011，，16： | 2 |
| 16 | Zuogui pills for myelinolysis in a rat model of experimental autoimmune encephalomyelitis显示文摘Zuogui pills have been shown to attenuate the inflammatory reaction in a rat model of experimental autoimmune encephalomyelitis(EAE).The present study attempted to investigate the pathology underlying the influence of Zuogui pills on myelinolysis in EAE rats.Hematoxylin-eosin and Luxol fast blue staining showed that the myelinolysis foci in the cerebrum,cerebellum,brain stem,and the spinal cord of EAE rats were significantly decreased,along with serum myelin basic protein content following treatment with Zuogui pills. | Yongping Fan Kelong Chen Kangning Li Jianping Zhou Yan Shao Hongyan Liu WenjingYang | 2011 | Neural Regeneration Research2011，6，9： | 2 |
| 17 | Hydrothermal ammoniated treatment of PAN-graphite felt for vanadium redox flow battery显示文摘 | Tao Wu Kelong Huang Suqin Liu Shuxin Zhuang Dong Fang Sha Li Dan Lu Anqun Su | 2012 | Journal of Solid State Electrochemistry2012，，2： | 2 |
| 18 | Nanoparticulate X-ray CT contrast agents显示文摘X-ray computed tomography(CT) has been widely used as a powerful diagnostic tool in clinics because it can provide high-resolution 3D tomography of the anatomic structure based on the distinctive X-ray absorptions between different tissues. Currently, CT contrast agents are mainly small iodinated molecules, which suffer from drawbacks such as short blood- retention time, nonspecific in vivo biodistribution, and renal toxicity. Utilization of nanoparticles as potential CT contrast agents to overcome the aforementioned issues has advanced rapidly. In this mini review, we introduce current research efforts in the development of nanoparticulate CT contrast agents and discuss the challenges for additional breakthroughs in this field. | Wenya He Kelong Ai Lehui Lu | 2015 | Science China Chemistry2015，58，5： | 2 |
| 19 | SYNTHESIS,PROPERTY AND HEAT STABILITY FO RPOLYVINYLCHLORIDSOFANTIMONYTRIS(MERCAPTOACIDESTER)显示文摘SYNTHESIS,PROPERTYANDHEATSTABILITYFORPOLYVINYLCHLORIDSOFANTIMONYTRIS(MERCAPTOACIDESTER)SYNTHESIS,PROPERTYANDHEATSTABILITYFORP... | Huang Kelong Liu Younian Gu Yingying Shu Wanyin(Department of Chemistry, Central South University of Technology, Changsha, 410083, China) | 1994 | Journal of Central South University1994，6，1： | 2 |
| 20 | Nanozyme:A promising tool from clinical diagnosis and environmental monitoring to wastewater treatment显示文摘Natural enzymes,owing to their outstanding catalytic efficiency and substrate specificity,have been used in a variety of applications including clinical diagnosis,environmental monitoring and wastewater treatment.However,they face inevitable problems such as relatively high cost and lack of stability,dramatically hindering their practical applications in the industry.Recently,a class of nanomaterial that possesses intrinsic enzyme-like properties,nanozyme,has emerged exhibiting numerous advantages over its natural counterpart and has been used as a viable enzyme alternative.In the past decade there are many reviews on nanozyme.The previous discussions tend to view nanozyme as a type of nanomaterial rather than an enzyme.However,it is the enzyme-like activity of nanozymes that provides foundation for their application and nanozymes with the same enzymatic activity usually have some regularity in application.Herein,in this review,we attempt to classify nanozymes by their enzyme-like activity to explain the application principle and relevant cases of nanozymes in clinical diagnosis,environmental monitoring and wastewater treatment,expecting to promote deeper thinking of nanozymes as enzyme mimics and provide useful guidance for future research. | Chaoyi Hong Xiangqin Meng Jiuyang He Kelong Fan Xiyun Yan | 2022 | Particuology2022，，12： | 2 |
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