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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | Three-week neonatal hypoxia reduces blood CGRP and cause persistent pul Monary hy Pretension in rats显示文摘 | Tjen-A-LooicS K ralcziH | 2000 | Am J Physiol Heart Cite Physiol2000，279，4： | 1 |
| 3 | mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung显示文摘 | Qing X Svaren J Keith IM | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，3： | 1 |
| 4 | The role of endogenous lung neuropeptid regulation of the pulmonary circulation显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
| 5 | 显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
| 6 | The role of endogenous lung neuropeptid regulation of the pulmonary circulation显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
| 7 | Cell relationship in a Wistar rat model of sponeaneous prostatitis显示文摘 | Keith IM Jin J Neal D Jr | 2001 | J Urol2001，166，1： | 1 |
| 8 | mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung 显示文摘 | Qing X Svaren J Keith IM | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，3： | 1 |
| 9 | The role of endogenous lung neuropeptides in regulation of the pulmonary eireulation显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
| 10 | Three week neonatal hypoxia reduces blood CGRP and cause persistent pul monary hypretension in rats显示文摘 | Keith IM Tjen - A - Looic S Kraiczi H | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 1 |
| 11 | The role of endogenous lung neuropeptides in regulation of the pulmonary circulation 显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
| 12 | Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results显示文摘AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) infection.METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic regression.RESULTS SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs. | Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch | 2017 | World Journal of Virology2017，6，4： | 1 |
| 13 | Cell relationship in a Wistar rat model of spontaneous prostatitis显示文摘 | Keith IM Jin J Neal D Jr | 2001 | J Urol2001，166，： | 1 |
| 14 | Cell relationship in a wistar rat model of spontaneous prostatitis显示文摘 | KEITH IM JIN J NEAL JR D | 2001 | J Urol2001，166，： | 1 |
| 15 | mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung 显示文摘 | Qing X Svaren J Keith IM | 2001 | Am J Physiol Lung Cell Mol Physiol2001，280，3： | 1 |
| 16 | Cell relationship in a Wister rat model Of spontaneous prostatitis显示文摘 | KEITH IM JIN J NEAL D | 2001 | J Urol2001，166，1： | 1 |
| 17 | The role of endogenous lung neuropeptides in regulation of the pulmonary circulation显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
| 18 | Three-week neonatal hypoxia reduces blood CGRP and cause persistent pulmonary hypretension rats显示文摘 | Keith IM Tjen-A-Looic S Kraiczi H | 2000 | Am J Physiol Heart Circ Physiol2000，279，4： | 1 |
| 19 | Dynamic aspects of regulatory peptides in chronic pulmonary hypertension显示文摘 | Keith IM Ekman R | 1992 | Exp Lung Res1992，18，： | 1 |
| 20 | The role of endogenous lung neuropeptid regulation of the pulmonary circulation 显示文摘 | Keith IM | 2000 | Physiol Res2000，49，5： | 1 |
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