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| 1 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 2 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 3 | Impacts and challenges of United States medical students during the COVID-19 pandemic显示文摘The delivery of medical student education has changed rapidly during the coronavirus disease 2019(COVID-19)pandemic.Students in their pre-clinical years have transitioned to online courses and examinations.Students in their clinical years are not permitted on clinical rotations,and face uncertainties in career exploration and the residency application process.Medical students in all stages of training are volunteering and helping their communities.The future presence of COVID-19 throughout the United States is unknown,and medical students are eager to return to their training.This paper outlines current challenges in medical student education and the various responses that have been adopted.We also discuss possible future directions for students through involvement in telemedicine,outpatient clinic visits,and non-respiratory inpatient care tasks as adequate personal protective equipment,COVID-19 testing,and resources become more widely available. | Stacey Rolak Alexis M Keefe Emily L Davidson Prabesh Aryal Sandesh Parajuli | 2020 | World Journal of Clinical Cases2020，8，15： | 2 |
| 4 | Interpersonal suicide risk for Allael'icarl Indians:investigating thwarted belongingness and perceived burden someness 显示文摘 | o' KEEFE V M WINGATE L R TUCKER R P | 2013 | Cultur Divers Ethnic Minor Psychol2013，26，： | 1 |
| 5 | Self-efficacy for Managing Pain, Symptoms, and Function in Patients with Lung Cancer and Their Informal Caregivers: Associations with Symptoms and Distress显示文摘 | Porter L S Keefe F J Garst J | 2008 | Pain2008，137，2： | 1 |
| 6 | Ageing-associated aberration in meiosis of oocytes from sensecence-accelerated mice 显示文摘 | Liu L Keefe D L | 2002 | Hum Reprod2002，17，： | 1 |
| 7 | Analysis of crab meat volatiles as possible spoilage indicators for blue crab (callinectes sapidus)meat by gas chromatography-Mass spec- trometry显示文摘 | Sarnoski P J O'Keefe S F Jahncke M L | 2010 | Food Chemistry2010，122，3： | 1 |
| 8 | Lamotrigine as add on therapy in schizuphrenia: results of 2 placebo-controlled trials 显示文摘 | Goff DC Keefe R Citrome L | 2007 | J Clin Psychophannaco12007，27，6： | 1 |
| 9 | Perspectives on cancer therapy-induced mucosal injury 显示文摘 | Sonis ST Ehing L Keefe D | 2004 | Cancer2004，10，： | 1 |
| 10 | Pharmacologic studies on radix puerariae: effect of puerarin on regional yocardial blood flow and cardiac hemodynamics in dogs with acute myocardial isochemia显示文摘 | Fan L L O'Keefe D D Powell W W J | 1985 | Chin Med J1985，98，： | 1 |
| 11 | LASIK surgery in children显示文摘 | Keefe M Nolan L | 2004 | Br J Ophthalmol2004，88，1： | 1 |
| 12 | Policy perspectives on occupational stress显示文摘 | O'KEEFE L C BROWN K C Christian B J | 2014 | Workplace Health Saf2014，62，10： | 1 |
| 13 | The self-efficacy of family caregivers for helping cancer patients ma-nage pain at end-of-life显示文摘 | Keefe F J Ahles T A Porter L S | | 0，，1： | 1 |
| 14 | Osteoclasts consititutively express regulators of bone resorption:an immunohistochemical and in situ hybridization study显示文摘 | O'Keefe R J Teot L A Singh D | 1997 | Lab Invest1997，76，4： | 1 |
| 15 | Determination of the binding of hexanal to soy glycinin and betaconglycinin in an aqueous model system using a headspace technique显示文摘 | O'KEEFE S F WILSON L A RESURRECCION A P | 1991 | Journal of Agricultural and Food Chemistry1991，39，6： | 1 |
| 16 | Trends in obesity and extreme obesity among US adults 显示文摘 | Main M L Rao S C O'Keefe J H | 2010 | JAMA2010，303，3： | 1 |
| 17 | Self-efficacy for managing pain, symptoms, and function in patients with lung cancer and their informal caregivers: Associations with symptoms and distress 显示文摘 | Porter L S Keefe F J Oarst J | 2008 | Pain2008，137，2： | 1 |
| 18 | Total parenteral nutrition in the critically ill patient:a meta-analysis显示文摘 | Heyland DK MacDonald S Keefe L | 1998 | JAMA1998，280，23： | 1 |
| 19 | Prostate cancer in african Americans : Relationship of patient and partner self-efficacy to quality of life显示文摘 | Campbell L C Keefe F J McKee D C | 2004 | J Pain Symptom Manage2004，28，5： | 1 |
| 20 | Telomerase deficiency impairs differentiation of mesenchymal stem cells显示文摘 | Liu L DiGirolamo C M Navarro P A Blasco M A Keefe D L | 2004 | Exp Cell Res2004，294，： | 1 |
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