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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Histogram analysis of MR imaging-derived cerebral blood volume maps:combined glioma grading and identification of low-grade oligodendroglial subtypes显示文摘AJNR, 2008 Jun 26.BACKGROUND AND PURPOSE: Inclusion of oligodendroglial tumors may confound the utility of MR based glioma grad-ing. Our aim was, first, to assess retrospectively whether a histogram-analysis method of MR perfusion images may both | Emblem KE Scheie D Due-Tonnessen P Nedregaard B Nome T Hald JK Beiske K Meling TR Bjornerud A | 2008 | 中国神经肿瘤杂志2008，6，2： | 5 |
| 3 | Preparation and photocatalytic activity of dysprosium doped tungsten trioxide nanoparticles 显示文摘 | Liu H J Peng T Y Ke D N | 2007 | Materials Chemistry and Physics2007，104，23： | 1 |
| 4 | The MYB transcription factor super-family of Arabidopsis:expression analysis and phylogenetic comparisonwith the rice MYB family显示文摘 | CHEN Y H YANG X Y HE Ke t al | 2006 | Plant Molecular Biology2006，60，： | 1 |
| 5 | Relative validity of a semi-quantitative food frequency questionnaire versus 3 day weighed diet records in middle-aged inhabitants in chaoshan area,china显示文摘 | Ke L Toshiro T Feng YS | 2005 | Asia Pac J Cancer Prev2005，6，： | 1 |
| 6 | Gene expression correlates of neurofibrillary tangles in Alzheimer's disease显示文摘 | Dunckley T Beach TG Ramsey KE | 2005 | Neurobiol Aging2005，19，： | 1 |
| 7 | Deep desulfurization of model gasoline by adsorption on mesoporous CeMCM-41 显示文摘 | KE T XIN H | 2010 | Pet Sci Technol2010，28，6： | 1 |
| 8 | Preparation and photocatalytic activity of WO3/TiO2 nanocomposite particles 显示文摘 | Ke D N Liu H J Peng T Y | 2008 | Materials Letters2008，62，3： | 1 |
| 9 | A comparison of intrathecal fentanyl and sufentanil for labor analgesia 显示文摘 | Nelson KE Rauch T Terebuh V | 2002 | Anesthesiology2002，96，5： | 1 |
| 10 | Acute abdominal pain as cause of hospitalization显示文摘 | Bjerkeset T Hivik S Aunu KE | 2006 | Tiddkr Nor Laegefoern2006，126，12： | 1 |
| 11 | Algal Growth Control Within Natural Water Purification Systems: Maerophyte Light Shading Effects显示文摘 | Yeh T Y Ke T Y Lin Y L | 2011 | Water Air Soil Pollut2011，214，： | 1 |
| 12 | Shadow prices of SO2 abate- ments ~or regions in China显示文摘 | KE T Y HU J L LI Y | 2008 | Agricultural and Resources Economics2008，5，2： | 1 |
| 13 | Novel CACNAIS mutation cau- ses autosomal dominant hypokalemic periodic paralysis in a South A- merican family显示文摘 | Ke T Gomez CR Mateus HE | 2009 | J Hum Genet2009，54，11： | 1 |
| 14 | Open reduction of subcondylar fractures: A study of functional rehabilitation显示文摘 | Bagenholm T Kahnberg KE | 1996 | Jnt J Oral Maxillofac Surg1996，25，： | 1 |
| 15 | Numerical simulation for optimizingthe design of subway environmental control system显示文摘 | Ke M Cheng T Wang W | 2002 | Building and Environment2002，37，11： | 1 |
| 16 | The economic burden of major adult visual disorders in the United States显示文摘 | Rein DB Zhang P Wirth KE Lee PP Hoerger T J McCall N | 2005 | Arch Ophthalmol2005，124，12： | 1 |
| 17 | Matrix cells from Wharton's jelly form neu- rons and glia显示文摘 | Mitchell KE ML Weiss BM Mitchell P Martin D Davis L Mo- rales B Helwig M Beerenstrauch K Abou - Easa T Hildreth D rroyer and S Medicetty | 2003 | Stem Cells2003，21，： | 1 |
| 18 | An Optimization Based Total Variation Image Denoising显示文摘 | Chan T F Chen Ke | 2006 | SIAM Journal on Multiscale Modeling and Simulation2006，5，2： | 1 |
| 19 | Integrated residential treatment for persons with severe and persistent mental illness: lessons in recovery显示文摘 | Davis KE Devitt T Rollins A | 2006 | Journal of Psychoactive Drugs2006，38，3： | 1 |
| 20 | PTX3 is located at the membrane of late apop- to-tic macrophages and mediates the phagocytosis of macrophages 显示文摘 | Guo T Ke L Qi B | 2012 | J Clin Immunol2012，32，2： | 1 |
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