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| 1 | Gender Affects the Median Effective Dose and 95% Effective Dose of Oxycodone for Blunting the Hemodynamic Response to Tracheal Intubation in Narcotic-Naive Adult Patients显示文摘 | Xian-Hui Kang Fang-Ping Bao Hong-Gang Zhang Dan-Jun Yu Ke Ha Qing Xie Sheng-Mei Zhu | 2018 | Chinese Medical Journal2018，，16： | 10 |
| 2 | Kavalactone yangonin induces autophagy and sensitizes bladder cancer cells to flavokawain A and docetaxel via inhibition of the mTOR pathway显示文摘Consumption of kava(Piper methysticum Forst) has been linked to reduced cancer risk in the South Pacific Islands.Kavalactones are major bioactive components in kava root extracts, which have recently demonstrated anti-cancer activities. However, molecular mechanisms of kavalactones' anti-cancer action remain largely unknown. We have identified two kavalactones, yangonin and 5' 6'-dehydrokawain, as potent inducers of autophagic cell death in bladder cancer cells. The effect of yangonin inducing autophagy is associated with increased expression of beclin and ATG5.In addition, yangonin increases the expression of LKB1 and decreases the phosphorylation of Akt, PRAS40, rpS6,p70S6 K and 4E-BP1, leading to increased binding of 4E-BP1 to m7 GTP. The growth inhibitory effects of yangonin were attenuated in TSC1 or LKB1 knockout mouse embryonic fibroblasts, suggesting that TSC1 and LKB1 expression may contribute to optimal growth inhibition by yangonin. Furthermore, yangonin reduces the viability of bladder cancer cell lines derived from different stages of human bladder cancer, and acts synergistically with apoptosis-inducing agents such as docetaxel and flavokawain A. Our results support a novel anti-bladder cancer mechanism by yangonin and further studies are needed to assess the potential use of yangonin for bladder cancer prevention and | Zhongbo Liu U-Syn Ha Ke Yu Chunli Wu Noriko Yokoyama Xiaolin Zi | 2017 | The Journal of Biomedical Research2017，31，5： | 4 |
| 3 | Clonal analysis of the differentiation potential of human adipose-derived adult stem cells 显示文摘 | Guilak F Lott KE Awad HA | 2006 | J Cell Physiol2006，206，1： | 1 |
| 4 | Association of testosterone and estradiol deficiency wtth osteoporosis and rapid bone loss in older men显示文摘 | Ewing SK Ensrud KE | 2006 | J Clin Endocrine Metab2006，91，10： | 1 |
| 5 | Droloxifene,a new estrogen antagonist/agonist, prevents bone loss in ovariectomized rats显示文摘 | Ke HZ Simmons HA Piric CM | 1995 | Endocrinology1995，136，： | 1 |
| 6 | Epidemiology and prognosis of breast cancer in young women显示文摘 | Assi HA Khoury KE Dbouk H | 2013 | J Thorac Dis2013，5，1： | 1 |
| 7 | Medical management to prevent recurrent nephrolithiasis in adults: A systematic review for an American College of Physicians Clinical Guideline显示文摘 | Fink HA Wilt TJ Eidman KE | 2013 | Ann Intern Med2013，158，7： | 1 |
| 8 | Differences in verbal memory performance in postmenopausal women receiving hormone therapy:17β-estradiol versus conjugated equine estrogens显示文摘 | Wroolie TE Kenna HA Williams KE | 2011 | Am J Geriatr Psychiatry2011，19，9： | 1 |
| 9 | Clonal analysis of multipotent differentiation of human adipose-derived adult stem sells显示文摘 | Guilak F Lott KE Awad HA | 2006 | J Cell Physiol2006，206，1： | 1 |
| 10 | Intussusception in adults: Intussusception review显示文摘 | Leon KE John DC Arthur HA | 1999 | J Am Coll Surg1999，188，4： | 1 |
| 11 | Epidemiology and prognosis of breast cancer in young women显示文摘 | Assi HA Khoury KE Dbouk H | 2013 | J Thorac Dis2013，51，： | 1 |
| 12 | Postcatheteriza-tion femoral artery pseudoaneurysms : therapeutic options, acase - controlled study显示文摘 | Heis HA Bani - Hani KE Elheis MA | 2008 | Int J Surg2008，6，3： | 1 |
| 13 | Splenic metastasis from adenocarcinoma of the prostate 显示文摘 | Naseem MS Jan HA Britton KE | 1998 | Br J Urol1998，82，4： | 1 |
| 14 | Clonal analysis of the differentiation potential of human adipose-derived adult stem cells显示文摘 | Guilak F Lott KE Awad HA | | 0，，： | 1 |
| 15 | Adrenal cav- ernous haemangioma显示文摘 | Heis HA Bani - Hani KE Bani - Hani BK | 2008 | Singapore ned J2008，49，9： | 1 |
| 16 | Use of statins and fracture:results of 4 prospective studies and cumulative meta-analysis of observational studies and controlled trials显示文摘 | Bauer DC Mundy GR Jamal SA Black DM Cauley JA Ensrud KE van der Klift M Pols HA | | 0，，2： | 1 |
| 17 | Uncertainties in the prevention and treatment of glucocorticoid-induced osteoporosis显示文摘 | Hansen KE Wilson HA Zapalowski C | 2011 | J Bone Miner Res2011，26，9： | 1 |
| 18 | Clonal analysis of the differentiation potential of human adipose-derived adult stem cells 显示文摘 | Guilak F Lott KE Awad HA | 2006 | J Cell Physiol2006，206，1： | 1 |
| 19 | Prolonged coagulation defeat ( deftbrination syndrome) in Malayan viper bite 显示文摘 | Reid HA Chan KE Thean PC | 1963 | Lancet1963，1，： | 1 |
| 20 | Carotid body tumors显示文摘 | Heis HA Bani-Hani KE | 2003 | Int Surg2003，88，4： | 1 |
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