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| 1 | 高纤维膳食和补充乙酸盐改变肠道菌群,预防醋酸脱氧皮质酮-盐型高血压小鼠高血压和心力衰竭的发展显示文摘水果和蔬菜的膳食摄入与高血压的发生率较低有关,但所涉及的机制尚未阐明。该研究评估了高纤维膳食和短链脂肪酸(short-chain fatty acid,SCFA)(乙酸盐)对肠道微生物群和预防心血管病的影响。方法:用盐皮质激素诱发小鼠高血压模型,观测正常喂食组、高纤维喂食组和补充乙酸盐组的肠道微生物、心脏结构/功能和血压水平。 | 刘莉 叶鹏 Marques FZ Nelson EM Chu PY Horlock D Fiedler A Ziemann M Tan JK Kuruppu S Rajapakse NW El-Osta A Mackay CR Kaye DM | 2016 | 中华高血压杂志2016，24，12： | 8 |
| 2 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 3 | Client-level predictors of treatment engagement,outcome and dropout:moving beyond demographics显示文摘Background Despite the availability of evidence-based treatments for posttraumatic stress disorder(PTSD),significant heterogeneity in the effectiveness of PTSD treatment persists,especially in community settings.Client demographics used to understand this variability in treatment outcome and dropout have yielded mixed results.Despite increasing evidence for the importance of attending to treatment engagement in community settings,few studies have explored client-level predictors.Aim The purpose of this study is to explore client-level predictors of treatment outcome and dropout beyond client demographics,and to identify client-level predictors of treatment engagement in community settings.Method Secondary data analysis was conducted with data collected as part of an implementation-effectiveness hybrid study of cognitive processing therapy(CPT)for PTSD in a diverse community healthcentre.Providers(n=19)treated(n=52)clients as part of their routine clinical care.Non-demographic client-level predictors included barriers to treatment,quality of life,session-level language and employment history assessed at baseline.Treatment engagement included number of weeks in the study,number of sessions with repeated CPT content,number of unique CPT sessions attended,frequency of session attendance and consistency of session attendance.Results Results showed language as a significant predictor of treatment engagement.There were significant differences between Spanish and English-speaking clients,with the former having a tendency to repeat more session content than the latter(β=1.4 sessions,p=0.003),and also less likely to attend treatment frequently(r=0.62,p=0.009)and consistently(r=0.57,p=0.027)if high logistical and financial barriers were endorsed.Irrespective of language,clients who reported high quality of life at baseline were less likely to repeat CPT session content(β=-0.3,p=0.04),and those with increased baseline barriers to treatment had deceleration in PTSD symptom improvement over time(β=-0.62,p<0.05).In terms of treatment engagement moderators impacting treatment outcome,clients who repeated more session content were more likely to complete treatment(0R=1.84,p=0.037).Conclusion Identification of client-level predictors of treatment engagement,outcome and dropout is essential to optimise treatment,particularly in community settings. | Soo-jeong Youn Margaret-Anne Mackintosh Shannon Wiltsey Stirman Kay lie A Patrick Yesenia Aguilar Silvan Anna D Bartuska Derri L Shtasel Luana Marques | 2019 | General Psychiatry2019，32，6： | 2 |
| 4 | Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes显示文摘 | van Duin D Kaye K S Neuner E A | 2013 | DiangMicrobiollnfectDis2013，75，2： | 1 |
| 5 | Tissue selec tive action of tamoxifen methiodide,raloxifene and tamoxifen on creatine kinas e B activity in vitro and in vivo显示文摘 | Waisman A Kaye AM | 1996 | J Steroid Biochem Mol Biol1996，59，56： | 1 |
| 6 | Treatment of polymyositis and dermaomyositis显示文摘 | Kaye S A Isenberg D A | 1994 | Br Hos J Med1994，52，9： | 1 |
| 7 | A comparison of three approaches to spatial generalization of rainfall-runoff models显示文摘 | Kay A L Jones D A Crooks S M | 2006 | Hydrology Processes2006，20，： | 1 |
| 8 | The Use of Thermodynamics and Phase Equilibra to Predict the Behavior of the Earth Elements Insteel 显示文摘 | Wilson W G Kay D A R Vaoed A | 1974 | Met1974，26，3： | 1 |
| 9 | Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003 显示文摘 | Druce J Tran T Kelly H Kaye M Chibo D Kostecki R Amiri A Catton M Birch C | 2005 | J Med Virol2005，75，1： | 1 |
| 10 | Antiadrenergic effect of chronic amiodarone 显示文摘 | Kaye D M Dart A M Jennings G L | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 11 | Analysis and compensa- tion of bandpass nonlinearities for communications显示文摘 | KAYE A GEORGE D ERIC M | 1972 | Com- munications IEEE Transactions on1972，20，5： | 1 |
| 12 | Molecular and phenotypic characterization of Als1 and Als2 mutations conferring tolerance to acetolactate synthase herbicides in soybean显示文摘 | Kay L Walter Stephen D Strachan Nancy M Ferry Henrik H Albert Linda A Castle Scott A Sebastian | 2014 | Pest. Manag. Sci2014，，12： | 1 |
| 13 | The role of cyclooxygenase in the feline pulmonary vascular bed 显示文摘 | Kaye A D Hoover J M Kaye A J | 2007 | Am J Therapeutics2007，14，： | 1 |
| 14 | Therapeutic application of RNAi is mRNA targeting finally ready for prime time?显示文摘 | GRIMM D KAY M A | 2007 | J Clin Invest2007，117，12： | 1 |
| 15 | The hand injury severity scoring system显示文摘 | Campbell D A Kay S P | 1996 | J Hand Surg Br1996，21，3： | 1 |
| 16 | Deterioration related to chloride ingress 显示文摘 | KAY E A FOOKES P G POLLOCK D J | 1981 | Concrete1981，15，6： | 1 |
| 17 | Chironomidae haemoglobins: their detection and role in allergy to midges in the Sudan and elsewhere 显示文摘 | Cranston P S Tee R D Credland P F Kay A B | 1983 | Memoirs of American Entomological Society1983，34，： | 1 |
| 18 | Conservation tillage and depth stratification of porosity and soil organic matter显示文摘 | Kay B D VandenBygaart A J | 2002 | Soil & Tillage Research2002，66，2： | 1 |
| 19 | Crashworthiness simulations with DYNA3D 显示文摘 | Schauer D A Hoover C G Kay G J | 1996 | Transportation Research Record1996，29，2： | 1 |
| 20 | The sensitivity of shoot growth of corn to theleast limiting water range of soils显示文摘 | DA SILVA A P KAY B D | 1996 | Plant and Soil1996，184，： | 1 |
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