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您的检索式：作者名="Katherine Z.Fu"
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| 1 | Effects of halobenzoquinone and haloacetic acid water disinfection byproducts on human neural stem cells显示文摘Human neural stem cells(h NSCs) are a useful tool to assess the developmental effects of various environmental contaminants; however, the application of h NSCs to evaluate water disinfection byproducts(DBPs) is scarce. Comprehensive toxicological results are essential to the prioritization of DBPs for further testing and regulation. Therefore, this study examines the effects of DBPs on the proliferation and differentiation of h NSCs. Prior to DBP treatment, characteristic protein markers of h NSCs from passages 3 to 6 were carefully examined and it was determined that h NSCs passaged 3 or 4 times maintained stem cell characteristics and can be used for DBP analysis. Two regulated DBPs, monobromoacetic acid(BAA) and monochloroacetic acid(CAA), and two emerging DBPs, 2,6-dibromo-1,4-benzoquinone(2,6-DBBQ) and 2,6-dichloro-1,4-benzoquinone(2,6-DCBQ), were chosen for h NSC treatment. Both 2,6-DBBQ and 2,6-DCBQ induced cell cycle arrest at S-phase at concentrations up to 1 μmol/L. Comparatively, BAA and CAA at 0.5 μmol/L affected neural differentiation. These results suggest DBP-dependent effects on h NSC proliferation and differentiation. The DBP-induced cell cycle arrest and inhibition of normal h NSC differentiation demonstrate the need to assess the developmental neurotoxicity of DBPs. | Katherine Z.Fu Jinhua Li Sai Vemula Birget Moe Xing-Fang Li | 2017 | Journal of Environmental Sciences2017，29，8： | 7 |
| 2 | Studying developmental neurotoxic effects of bisphenol A(BPA) using embryonic stem cells显示文摘There is little to no toxicity information regarding thousands of chemicals to which people are exposed daily.In fact,of the84,000 chemicals listed in the United States Toxic Substances Control Act Inventory,there is limited information available on their effects on neural development(Betts,2010;US EPA,2015).The number of chemicals tested remains low due to the high cost of conducting multi-generational animal | Jinhua Li Katherine Z.Fu Sai Vemula X.Chris Le Xing-Fang Li | 2015 | Journal of Environmental Sciences2015，27，10： | 6 |
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