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| 1 | Reversed-phase fused-core HPLC modeling of peptides显示文摘Different fused-core stationary phase chemistries(C18,Amide,Phenyl-hexyl and Peptide ES-C18) were used for the analysis of 21 structurally representative model peptides.In addition,the effects of the mobile phase composition(ACN or MeOH as organic modifier;formic acid or acetic acid,as acidifying component) on the column selectivity,peak shape and overall chromatographic performance were evaluated.The RP-amide column,combined with a formic acid-acetonitrile based gradient system,performed as best.A peptide reversed-phase retention model is proposed,consisting of 5 variables:log SumAA,log Sv,clog P,log nHDon and log nHAcc.Quantitative structure-retention relationship(QSRR) models were constructed for 16 different chromatographic systems.The accuracy of this peptide retention model was demonstrated by the comparison between predicted and experimentally obtained retention times,explaining on average 86% of the variability.Moreover,using an external set of 5 validation peptides,the predictive power of the model was also demonstrated.This peptide retention model includes the novel in-silico calculated amino acid descriptor,AA,which was calculated from log P,3D-MoRSE,RDF and WHIM descriptors. | Matthias D'Hondt Bert Gevaert Sofie Stalmans Sylvia Van Dorpe Evelien Wynendaele Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 3 |
| 2 | Early Endoscopic Retrograde Cholangiopancreatography in Predicted Severe Acute Biliary Pancreatitis: A Prospective Multicenter Study显示文摘 | Hjalmar C. van Santvoort Marc G. Besselink Annemarie C. de Vries Marja A. Boermeester Kathelijn Fischer Thomas L. Bollen Geert A. Cirkel Alexander F. Schaapherder Vincent B. Nieuwenhuijs Harry van Goor Cees H. Dejong Casper H. van Eijck Ben J. Witteman Ba | 2009 | Annals of Surgery2009，，1： | 2 |
| 3 | Bacterial carbonate precipitation as an alternative surface treatment for concrete显示文摘 | Willem D M Kathelijn C Nele D B | 2008 | Construction and Building Materials2008，22，5： | 1 |
| 4 | Tnteractions of antifungal plant defensins with fungal membrane component 显示文摘 | THEVISSEN K KATHELIJNE K A | 2003 | Peptides2003，24，： | 1 |
| 5 | Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis显示文摘 | Marc G. Besselink Hjalmar C. van Santvoort Willem Renooij Martin B. de Smet Marja A. Boermeester Kathelijn Fischer Harro M. Timmerman Usama Ahmed Ali Geert A. Cirkel Thomas L. Bollen Bert van Ramshorst Alexander F. Schaapherder Ben J. Witteman Rutger J. P | 2009 | Annals of Surgery2009，，5： | 1 |
| 6 | Risk evaluation of impurities in topical excipients:The acetol case显示文摘Pharmaceutical excipients for topical use may contain impurities,which are often neglected from a toxicity qualification viewpoint.The possible impurities in the most frequently used topical excipients were evaluated in-silico for their toxicity hazard.Acetol,an impurity likely present in different topical pharmaceutical excipients such as propylene glycol and glycerol,was withheld for the evaluation of its health risk after dermal exposure.An ex-vivo in-vitro permeation study using human skin in a Franz Diffusion Cell set-up and GC as quantification methodology showed a significant skin penetration with an overall K_p value of 1.82 × 10^(-3)cm/h.Using these data,limit specifications after application of a dermal pharmaceutical product were estimated.Based on the TTC approach of Cramer class I substances,i.e.1800 μg/(day·person),the toxicity-qualified specification limits of acetol in topical excipients were calculated to be 90 μg/mL and 180 μg/mL for propylene glycol and glycerol,respectively. | Jente Boonen Lieselotte Veryser Lien Taevernier Nathalie Roche Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 1 |
| 7 | A proposal for repro- ductive counseling in carriers of Robertsonian translocations : 10 years of experience with preimplantation genetic diagnosis 显示文摘 | Kathelijn K Catherine S Willem V | 2009 | Hum Re- prod2009，24，9： | 1 |
| 8 | Factor XIII Val34Leu mutation accelerates the development of fibrosis in patients with chronic hepatitis B and C显示文摘 | Kathelijne Dik Joep de Bruijne R. Bart Takkenberg Joris J. Roelofs Marjan J. Tempelmans Marcel G. W. Dijkgraaf Huub C. Gelderblom Henk W. Reesink Joost C. M. Meijers Peter L. Jansen Marcel Levi | 2012 | Hepatology Research2012，，7： | 1 |
| 9 | Intestinal Barrier Dysfunction in a Randomized Trial of a Specific Probiotic Composition in Acute Pancreatitis显示文摘 | Marc G. Besselink Hjalmar C. van Santvoort Willem Renooij Martin B. de Smet Marja A. Boermeester Kathelijn Fischer Harro M. Timmerman Usama Ahmed Ali Geert A. Cirkel Thomas L. Bollen Bert van Ramshorst Alexander F. Schaapherder Ben J. Witteman Rutger J. P | 2009 | Annals of Surgery2009，，5： | 1 |
| 10 | A proposal for reproductivecounseling in carriers of Robertsonian translocations:10 years of ex-perience with preimplantation genetic diagnosis显示文摘 | Kathelijn K Catherine S Willem V | 2009 | Hum Reprod2009，24，9： | 1 |
| 11 | Indirect larynx and pharynx Surgery: a replacement for direct laryngoscopy显示文摘 | Robert WB Kathelijne GD | 1996 | Laryngoscope1996，106，： | 1 |
| 12 | Coping Style and quality of life in patients with epilepsy:a cros-sectional study显示文摘 | Willemien Westerhuis Maeike Zijlmans Kathelijn Fischer | 2011 | J Neurol2011，258，： | 1 |
| 13 | Bacterial carbonate precipitation as an alternative surface treatment for concrete显示文摘 | Willem De Muynck Kathelijn Cox Nele De Belie Willy Verstraete | 2007 | Construction and Building Materials2007，，5： | 1 |
| 14 | Bacterial carbonate precipitation as an alternative surface treatment for concrete 显示文摘 | Willem De Muynck Kathelijn Cox Nele De Belie | 2008 | Construction and Building Materials2008，22，5： | 1 |
| 15 | A proposal for reproductive counseling in carriers of Robertsonian translocations:10years of experience with preimplantation genetic diagnosis显示文摘 | Kathelijn K Catherine S Willem V | 2009 | Hum Reprod2009，24，9： | 1 |
| 16 | A critical quality parameter in quantitative fused-core chromatography: The injection volume显示文摘As part of the method development,the injection volume as a critical quality attribute in fast fused-core chromatography was evaluated.Spilanthol,a pharmaceutically interesting Nalkylamide currently under investigation in our laboratory,was chosen as the model compound.Spilanthol was dissolved in both PBS and MeOH/H2O(70/30,v/v)and subsequently analyzed using a fused-core system hereby selecting fve chromatographic characteristics(retention time,area,height,theoretical plates and symmetry factor)as responses.We demonstrated that the injection volume signifcantly influenced both the qualitative and quantitative performance of fused-core chromatography,a phenomenon which is confounded with the nature of the used sample solvent.From 2 mL up to 100 mL injection volume with PBS as solvent,the symmetry factor decreased favorably by 20%.Moreover,the theoretical plates and the quantitative parameters(area and height)increased up to 30%.On the contrary,in this injection volume range,the theoretical plates for the methanol-based samples decreased by more than 60%,while the symmetry factor increased and the height decreased,both by 30%.The injection volume is thus a critical and often overlooked parameter in fused-core method description and validation. | Jente Boonen Matthias D’hondt Lieselotte Veryser Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，5： | 0 |
| 17 | Analysis of iodinated quorum sensing peptides by LC–UV/ESI ion trap mass spectrometry显示文摘Five different quorum sensing peptides(QSP) were iodinated using different iodination techniques. These iodinated peptides were analyzed using a C18 reversed phase HPLC system, applying a linear gradient of water and acetonitrile containing 0.1%(m/v) formic acid as mobile phase. Electrospray ionization(ESI)ion trap mass spectrometry was used for the identification of the modified peptides, while semi-quantification was performed using total ion current(TIC) spectra. Non-iodinated peptides and mono-and diiodinated peptides(NIP, MIP and DIP respectively) were well separated and eluted in that order. Depending on the used iodination method, iodination yields varied from low(2%) to high(57%). | Yorick Janssens Frederick Verbeke Nathan Debunne Evelien Wynendaele Kathelijne Peremans Bart De Spiegeleer | 2018 | Journal of Pharmaceutical Analysis2018，8，1： | 0 |
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