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| 1 | 肯尼亚内罗毕地区HIV携带者和艾滋病患者饮用中药Restore Plus颗粒冲剂提高免疫功能降低病毒载量的初步研究显示文摘目的:评价肯尼亚内罗毕地区HIV携带者和艾滋病(AIDS)患者饮用Restore Plus颗粒冲剂22个月后受试者免疫功能的改善情况。方法:将29~49岁的受试者71人随机分为2组:安慰剂组(n=30)和Restore Plus颗粒冲剂组(n=41)。其中61人(80%以上)为低收入、低教育背景的单身、已婚或离异女性。结果:与安慰剂组相比,服用Restore Plus的患者在服用期间和后续时间内,食欲、体重、身体机能、低体温方面均有所改善,特别是HIV和AIDS体征性状改善更佳,主要表现在:患者中有腹泻症状者的比例从10.5%降至0%;上呼吸道感染者从10.5%降至0%;头疼患者从15.8%降至4.0%;皮疹者从21.1%降至4.2%;感觉乏力者从15.8%降至0%。85.7%的患者在服用第12个月可见改善。而且,服用Restore Plus患者的CD 3+和CD 4+淋巴细胞计数增高,HIV病毒载量明显降低,甚至低于检测限。对服用者的肝功能检测表明其与对照组之间较为一致,未显示对肝脏的不良反应。结论:服用Restore Plus的患者没有出现毒性作用,用其对抗HIV感染和AIDS,患者免疫功能恢复,病毒载量可低于检测下限。服用Restore Plus将是HIV携带者和AIDS患者的可选辅助治疗方案。 | 鲁自云 Charles F.L.Mbakaya Yeri Kombe Wilfred Kisingu James Kariuki Erastus Muniu Lucy Kanyara 方静 毛建平 | 2011 | 中国新药杂志2011，20，22： | 9 |
| 2 | Bacteriophages Isolated in China for the Control of Pectobacterium carotovorum Causing Potato Soft Rot in Kenya显示文摘Soft rot is an economically significant disease in potato and one of the major threats to sustainable potato production.This study aimed at isolating lytic bacteriophages and evaluating methods for and the efficacy of applying phages to control potato soft rot caused by Pectobacterium carotovorum.Eleven bacteriophages isolated from soil and water samples collected in Wuhan,China,were used to infect P.carotovorum host strains isolated from potato tubers showing soft rot symptoms in Nakuru county,Kenya.The efficacy of the phages in controlling soft rot disease was evaluated by applying individual phage strains or a phage cocktail on potato slices and tubers at different time points before or after inoculation with a P.carotovorum strain.The phages could lyse 20 strains of P.carotovorum,but not Pseudomonas fluorescens control strains.Among the 11 phages,Pectobacterium phage Wc5r,interestingly showed cross-activity against Pectobacterium atrosepticum and two phage-resistant P.carotovorum strains.Potato slice assays showed that the phage concentration and timing of application are crucial factors for effective soft rot control.Phage cocktail applied at a concentration of 1×10^9 plaque-forming units per milliliter before or within an hour after bacterial inoculation on potato slices,resulted in>90%reduction of soft rot symptoms.This study provides a basis for the development and application of phages to reduce the impact of potato soft rot disease. | Peter Muturi Junping Yu Alice Nyambura Maina Samuel Kariuki Frantis B.Mwaura Hongping Wei | 2019 | Virologica Sinica2019，34，3： | 4 |
| 3 | Physiological functions of hemocytes newly emerged from the cultured hematopoietic organs in the silkworm, Bombyx moil显示文摘 | Cheng-Long Wang Zhi-Xiang Wang Michael M. Kariuki Qing-Zhi Ling Kenji Kiguchi Er-Jun Ling | 2010 | Insect Science2010，17，1： | 3 |
| 4 | Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo 显示文摘 | KARIUKI S N KIROU K A MACDERMOTY E J | 2009 | J Immunol2009，182，1： | 1 |
| 5 | Genetic regulation of serum cytokines in systemic lupus erythematosus 显示文摘 | Kariuki SN Niewold TB | 2010 | Transl Res2010，155，3： | 1 |
| 6 | 显示文摘 | Hix G B Kariuki g M Kitchin S | 2001 | Inorg Chem2001，40，： | 1 |
| 7 | Contemporary ad- vances in the use of powder X-ray diffraction for structure determination显示文摘 | Harris K D M Tremayne M Kariuki B M | 2001 | Angew Chem Int Ed2001，40，： | 1 |
| 8 | Modelling the impacts of various thinning intensities on tree growth and survival in a mixed species eucalypt forest in cen- tral Gippsland, Victoria, Australia 显示文摘 | Kariuki M | 2008 | Forest Ecology and Manage- ment2008，256，： | 1 |
| 9 | Molecular characterization of a novel plasmid-encoded cefotaximase(CTX-M-12) found in clinical Klebsiella pneunmoniae isolates from Kenya显示文摘 | Kariuki S Corkill JE Revathi G | 2001 | Antimicrob Agents Chemother2001，45，7： | 1 |
| 10 | Peste des Petits RuminantsAntibodies in East-Africa显示文摘 | WAWSAYI H M ROSSITER P B KARIUKI D P | 1995 | Vet Rec1995，136，8： | 1 |
| 11 | Assessment of customer outage costs due to electric service interruptions:residential sector显示文摘 | Kariuki K K Allan R N | 1996 | IEEE Proceedings of Generation Transmission Distribution1996，142，2： | 1 |
| 12 | Mid-Season Prediction of Wheat-Grain Yield Potential Using Plant, Soil, and Sensor Measurements显示文摘 | K. Girma K. L. Martin R. H. Anderson D. B. Arnall K. D. Brixey M. A. Casillas B. Chung B. C. Dobey S. K. Kamenidou S. K. Kariuki E. E. Katsalirou J. C. Morris J. Q. Moss C. T. Rohla B. J. Sudbury B. S. Tubana W. R. Raun | 2006 | Journal of Plant Nutrition2006，，5： | 1 |
| 13 | Detection of a carrier state in Theileria parva-infected cattle by the polymerase chain reaction显示文摘 | Bishop R Sohanpal B Kariuki D P | 1992 | Parasitol1992，104，2： | 1 |
| 14 | Prevalence and se- verity of anemia and iron deficiency: cross - sectional studies in adolescent school girls in western Kenya显示文摘 | Leenstra T Kariuki SK Kurtis JD | 2004 | Eur J Clin Nutr2004，58，4： | 1 |
| 15 | Bimetallic Pd Cu oxygen reduction electrocatalysts显示文摘 | Wang X P Kariuki N Vaughey J T | | 0，，06： | 1 |
| 16 | Colloidal synthesis and characterization of carbon-supported Pd-Cu nanoparticle oxygen reduction electrocatalysts显示文摘 | Kariuki N N Wang X P Mawdsley J R | | 0，，14： | 1 |
| 17 | Evaluation of loop- mediated isothermal amplification suitable for molecular monitoring of schistosome-infected snails in field laboratories 显示文摘 | Hamburger J Abbasi I Kariuki C | 2013 | Am J Trop Med Hyg2013，88，2： | 1 |
| 18 | Increasing prevalence of multidrug - resistant non - typhoidal salmonella, Kenya, 1994 - 2003 显示文摘 | KARIUKI S REVATHI G KARIUKI N | 2005 | J Antimicrob Agen2005，，25： | 1 |
| 19 | Molecular characterization of a novel plasmid-encoded cefotaximases (CTX-M-12) found in clinical Klebsiella pneumoniae isolates from Kenya 显示文摘 | Kariuki S Corkill J E Revathi G | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 20 | Incidence of epilepsy: a systematic review and meta-analysis显示文摘 | Nquqi A K Kariuki S M Bottomley C | 2011 | Neurology2011，77，10： | 1 |
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