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9篇 您的检索式：作者名="Karam AM"

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		题名	作者	年代	出处	被引量
	1	Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation.	Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam	2011	World Journal of Gastroenterology2011，17，33：	3
	2	Short-scar purse-string facelift 显示文摘	Karam AM Nayak LM Lam SM	2009	Facial Plast Surg Clin North Am2009，17，4：	1
	3	Posttraumatic Aeromonas hydrophila osteomyelitis显示文摘	Karam GH Ackley AM Dismukes WE	1983	Arch Intern Med1983，143，：	1
	4	Short-scar purse-string faeel- ift显示文摘	Karam AM Nayak LM Lain SM	2009	Facial Plast Surg Clin North Am2009，17，4：	1
	5	Management of the Asian upper eyelid显示文摘	Karam AM Lam SM	2010	Facial Plast Surg Clin North Am2010，18，：	1
	6	Management of the aging upper eyelid in the asian patient显示文摘	Karam AM Lam SM	2010	Facial Plast Surg2010，26，3：	1
	7	Novel endoscopic management of penetrating intracranial trauma显示文摘	Sepehr A Karam AM Wong BJ	2010	Ann Otol Rhinol Laryngol2010，119，11：	1
	8	Prospective trial to identify optimal bladder cancer surveillance protocol: reducing costs while maximizing sensitivity 显示文摘	Kamat AM Karam JA Grossman HB	2011	BJU Int2011，108，7：	1
	9	Supratarsal crease creation in the Asian up- per eyelid 显示文摘	Lam SM Karam AM	2010	Facial Plast Surg Clin North Am2010，18，1：	1

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