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| 1 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 2 | A selective disassembly methodology for end-of-life products显示文摘 | KARA S POMPRASITPOL P KEBEMICK H | 2005 | Assembly Automation2005，25，2： | 1 |
| 3 | Statin-associated myopathy显示文摘 | Thompson PD Clarkson P Karas RH | 2003 | JAMA2003，289，： | 1 |
| 4 | A survey of mea-sures used for the prevention of postoperative endophthalmitis aftercataract surgery in the United Kingdom显示文摘 | Gordon-Bennett P Karas A Flanagan D | 2008 | Eye2008，22，5： | 1 |
| 5 | Statin- associated myopathy显示文摘 | Thompson PD Clarkson P Karas RH | 2003 | JAMA2003，289，： | 1 |
| 6 | Global convergence of slanting filter methods for nonlinear programming显示文摘 | Karas E W Oening A P Ribeiro A A | 2008 | Applied Mathematics and Computation2008，200，2： | 1 |
| 7 | Statin-associated myopathy 显示文摘 | THOMPSON PD LARKSON P KARAS RH | 2003 | JAMA2003，289，13： | 1 |
| 8 | Endoscopic treatment of high-grade dysplasia and early stage cancer in Barrett's esophagus显示文摘 | PETERS F P KARA M A ROSMOLEN W D | 2005 | Gastrointest Endos2005，61，4： | 1 |
| 9 | A Distribution Network Optimization Problem for Third Party Logistics Service Providers 显示文摘 | BA~LIGIL H KARA S S ALCAN P | 2011 | Expert Systems with Applications2011，38，12： | 1 |
| 10 | High-resolution endoscopy plus chromoendoscopy or narrow-band imaging in Barretts esophagus:a prospective randomized crossover study显示文摘 | Kara M A Peters F P Rosmolen W D | | 0，，10： | 1 |
| 11 | Detection and classi-fica- tion of the mucosal and Vascular patterns ( mucosal morphology ) in Barrett' s esophagus by using narrow band imaging 显示文摘 | Kara MA Ennahachi M Fockens P | 2006 | Gastrointest Endosc2006，64，2： | 1 |
| 12 | Negative Mood and Quality of Life in Patients with Asthma显示文摘 | Aydanur Ekici Mehmet Ekici Turkan Kara Hatice Keles P?nar Kocyigit | 2006 | Quality of Life Research2006，，1： | 1 |
| 13 | Clinical pharmacokinetics of clopidogrel and its metabolites in patients with cardiovascular diseases显示文摘 | Kara?niewicz-?ada M Danielak D Burchardt P | 2014 | Clin Pharmcokinet2014，53，2： | 1 |
| 14 | Detection and classification of mucosal and vascular patterns in Barrett' esophagus by using narrow band imaging显示文摘 | Kara MA Ennahachi M Fochens P | 2006 | Gastrointest Endosc2006，84，2： | 1 |
| 15 | Direct electrochemical genosensing for multiple point mutation detection of Mycobacterium tuberculosis during the development of rifampin resistance显示文摘 | Kara P Cavusoglu C Cavdar S | 2009 | Biosens Bioeleetron2009，24，6： | 1 |
| 16 | Global and local gray matter loss in mild cognitive impairment and Alzheimerˊs disease显示文摘 | Karas GB Scheltens P Rombouts SA | 2009 | Neuroimage2009，23，7： | 1 |
| 17 | Effects of temperature and salinity on embryonic development turbot from the North sea,and comparisions with Baltic populations显示文摘 | KARAS P KLINGSHEIM V | 1997 | Helgolander Meerseuntersuchungern1997，51，2： | 1 |
| 18 | In vivo characterisation of parathyroid lesions by use of gamma probe: comparison with ex vivo count method and frozen section results 显示文摘 | Ugur O Kara P O Bozkurt M F | 2006 | Otolaryngol Head Neck Surg2006，134，2： | 1 |
| 19 | Startin-associated myopathy显示文摘 | Thompson PD Clrkson P Karas RH | 2003 | JAMA2003，289，： | 1 |
| 20 | Detection and classification of the mucosal and vascular patterns (mucosal morphology)in barrett's esophagus by using nanw band imaging显示文摘 | Kara MA Ennahachi M Fockens P | 2006 | Gastrointest Endosc2006，64，2： | 1 |
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