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| 1 | Overexpressed long noncoding RNA CRNDE with distinct alternatively spliced isoforms in multiple cancers显示文摘Alternative splicing is a tightly regulated process that contributes to cancer development.CRNDE is a long noncoding RNA with alternative splicing and is implicated in the pathogenesis of several cancers.However,whether deregulated expression of CRNDE is common and which isoforms are mainly involved in cancers remain unclear.In this study,we report that CRNDE is aberrantly expressed in the majority of solid and hematopoietic malignancies.The investigation of CRNDE expression in normal samples revealed that CRNDE was expressed in a tissue- and cell-specific manner.Further comparison of CRNDE expression in 2938 patient samples from 15 solid and hematopoietic tumors showed that CRNDE was significantly overexpressed in 11 malignancies,including 3 reported and 8 unreported,and also implicated that the overexpressed isoforms differed in various cancer types.Furthermore,anti-cancer drugs could efficiently repress CRNDE overexpression in cancer cell lines and primary samples,and even had different impacts on the expression of CRNDE isoforms.Finally,experimental profiles of 12 alternatively spliced isoforms demonstrated that the spliced variant CRNDE-g was the most highly expressed isoform in multiple cancer types.Collectively,our results emphasize the cancer-associated feature of CRNDE and its spliced isoforms,and may provide promising targets for cancer diagnosis and therapy. | Xuefei Ma Wei Zhang Rong Zhang Jingming Li Shufen Li Yunlin Ma Wen Jin Kankan Wang | 2019 | Frontiers of Medicine2019，13，3： | 3 |
| 2 | Serious BTEX pollution in rural area of the North China Plain during winter season显示文摘Atmospheric BTEX compounds(benzene, toluene, ethylbenzene and xylenes) in a rural site of the North China Plain(NCP) were preliminarily investigated in winter, and the outdoor concentrations(25.8–236.0 μg/m3) were found to be much higher than those reported in urban regions. The pollution of BTEX inside a farmer's house was even more serious, with combined concentrations of 254.5–1552.9 μg/m3. Based on the ratio of benzene to toluene(1.17 ± 0.34) measured, the serious BTEX pollution in the rural site was mainly ascribed to domestic coal combustion for heating during the winter season. With the enhancement of farmers' incomes in recent years, coal consumption by farmers in the NCP is rapidly increasing to keep their houses warm, and hence the serious air pollution in rural areas of the NCP during winter, including BTEX, should be paid great attention. | Kankan Liu Chenglong Zhang Ye Cheng Chengtang Liu Hongxing Zhang Gen Zhang Xu Sun Yujing Mu | 2015 | Journal of Environmental Sciences2015，27，4： | 2 |
| 3 | Pan-cancer analysis of long non-coding RNA NEAT1 in various cancers显示文摘Changes in the abundance and activity of long non-coding RNAs(lncRNAs)have an important impact on the development of cancer.The nuclear paraspeckle assembly transcript 1(NEAT1)has been reported to be overexpressed in many types of cancer since its discovery.However,inconsistencies exist as NEAT1 can also function as a tumor suppressor in certain types of cancer,such as acute promyelocytic leukemia.Here we systematically describe our current understanding of NEAT1 in tumor initiation and progression.First,we analyzed the expression patterns of NEAT1 in various normal tissues and malignant cancers using data from public data portals,the Genotype-Tissue Expression Project(GTEx)and the Cancer Genome Atlas(TCGA),together with recent progress in the study of NEAT1 in various types of cancer.Second,we discussed the functions and mechanisms of NEAT1 in modulating tumor activity.Then,the upstream transcription factors and downstream microRNA targets of NEAT1 in the transcription cascade of cancers were also summarized.These data highlight the emerging role of NEAT1 in tumorigenesis,and present promising targetable pathways and clinical opportunities for tumor prevention and classifications. | Shufen Li Jingming Li Chen Chen Rongsheng Zhang Kankan Wang | 2018 | Genes & Diseases2018，5，1： | 2 |
| 4 | 亚热带森林植物群落沿海拔梯度的分类与系统发育研究显示文摘生物多样性沿海拔梯度的分布格局已受到广泛关注。然而,生物多样性格局沿海拔梯度的变异及其潜在机制尚不清楚。整合生物多样性的多维度信息为理解群落构建机制提供了新思路。本研究在我国东部亚热带森林沿海拔270-1470 m的梯度上设置了17个木本植物固定样地,分析了沿海拔梯度植物群落构建的生态和进化驱动力。基于样地内物种出现(0-1数据)和多度信息,计算群落内被子植物的物种和系统发育alpha和beta多样性、系统发育结构等,并量化多样性指标与微气候和地形之间的关系。研究发现,不论多度加权与否,物种alpha多样性均沿海拔升高而增加,物种和系统发育的相似性随海拔距离的增加而呈衰减趋势。然而,多度加权与否会形成不同的系统发育alpha多样性格局。对于系统发育结构而言,沿海拔增加并无明显趋势。地形和微气候是多样性格局和系统发育结构的主要驱动力。与未考虑物种多度的多样性指标相比,多度加权的指标与坡度和胸高断面积相关性更高。这些结果表明,由局域物种多度介导的确定性过程对沿海拔梯度的植物群落构建具有一定影响。 | Ran Zhang Zhaochen Zhang Kankan Shang Mingshui Zhao Jiaxin Kong Xin Wang Yuzhuo Wang Houjuan Song Oukai Zhang Xuan Lv Jian Zhang | 2021 | Journal of Plant Ecology2021，14，4： | 2 |
| 5 | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY AND GAS CHROMATOGRAPHY — MASS SPECTROMETRY METHODS FOR THE DETERMINATION OF IMIDACLOPRID, CHLORPYRIFOS, AND BIFENTHRIN RESIDUES IN TEA LEAVES显示文摘 | Nan Gao Xiaochuan Guo Kankan Zhang Deyu Hu | 2014 | Instrumentation Science & Technology2014，，3： | 1 |
| 6 | Instrumentation system for thermal analysis of electro-explosive devices显示文摘 | Kankane D K Ranade S N Sohoni R B Deshpande G S | 1999 | Defence Science Journal1999，49，1： | 1 |
| 7 | Responsive polymers in controlled drug delivery 显示文摘 | Bajpai A K Shukla S K Bhanu S Kankane S | | Progress in Polymer Science0，33，11： | 1 |
| 8 | Potential starter/ generator technologies for future aerospace applications 显示文摘 | Elbuluk M E Kankan M D | 1997 | IEEE AES Systems1997，21，5： | 1 |
| 9 | Preparation and Characterization of Maeroporous Poly( 2-hydroxyethyl methacrylate) - Based Biomaterials: Water Sorption Property and In Vitro Blood Compatibility 显示文摘 | Bajpai A K Kankane S | 2007 | Journal of Applied Polymer Science2007，104，： | 1 |
| 10 | The Path of Fine Leisure Agriculture in Southern Shaanxi from the Perspective of Rural Revitalization显示文摘Under the strategy of rural revitalization in China, the existing leisure agriculture needs to constantly think about how to make better use of the geographical resources of each region in the process of development, and to improve the quality of local leisure agriculture projects. Taking the leisure agriculture in the southern part of Shaanxi Province of China for example, this paper summarized the existing problems in the development, and proposed the path of fine leisure agriculture based on these problems, so as to provide direction to specify the planning orientation of fine leisure agriculture in Southern Shaanxi and improve the brand value of leisure agriculture and provide a reference for the fine development of leisure agriculture in other parts of China. | LI Kankan ZHAI Yang TANG Ying LIU Jianjun | 2019 | Journal of Landscape Research2019，11，3： | 1 |
| 11 | Energy use efficiency in the Indian manufacturing sector: an interstate analysis 显示文摘 | Mukherjee Kankan | 2008 | Energy Policy2008，，2： | 1 |
| 12 | A novel algorithm of extended neural networks for image recognition显示文摘 | Dai Kankan Zhao Jianwei Cao Feilong | 2015 | Engineering Applications of Artificial Intelligence2015，42，： | 1 |
| 13 | Evaluation of water sorption property and in vitro blood compatibility of poly(2-hydroxyethyl methacrylate) (PHEMA) based semi interpenetrating polymer networks (IPNs)显示文摘 | BAJPAI A K KANKANE S | 2008 | Journal of Materials Science2008，19，5： | 1 |
| 14 | A heteropolysaccharide from aqueous extract of an edible mushroom, Pleurotus ostreatus cultivar: structural and biological studies显示文摘 | Kankan K. Maity Sukesh Patra Biswajit Dey Sanjoy K. Bhunia Soumitra Mandal Debsankar Das Dibyendu K. Majumdar Swatilekha Maiti Tapas K. Maiti Syed S. Islam | 2010 | Carbohydrate Research2010，，2： | 1 |
| 15 | Enantiomeric Separation of Indoxacarb on an Immobilized Amylose-based Chiral Stationary Phase and Its Application in the Degradation of Indoxacarb Enantiomers in Water显示文摘 | YUPING Z KANKAN Z BAOAN S | 2014 | Biomedical Chromatography2014，28，： | 1 |
| 16 | Potential starter/generator technologies for future aerospace applications 显示文摘 | Elbuluk M E Kankan M D | 1997 | IEEE AES Systems1997，21，5： | 1 |
| 17 | Tetrabromobisphenol A (TBBPA) and hexabromocyclododecanes in tis- sues of humans, dolphins, and sharks from the United States显示文摘 | JOHNSON-RESTREPO B ADAMS D H KANKAN K | 2008 | Chemosphere2008，70，： | 1 |
| 18 | Responsive polymers in controlled drug delivery显示文摘 | Bajpai AK Shukla SK Bhanu S Kankane S | 2008 | Progress in Polymers Science2008，33，11： | 1 |
| 19 | Converting redox signaling to apoptotic activities by stress-responsive regulators HSF1 and NRF2 in fenretinide treated cancer cells显示文摘 | Wang Kankan Fang Hai Xiao Dakai | 2009 | PLoS One2009，4，10： | 1 |
| 20 | Potential starter/generator technologies for future aerospace applications显示文摘 | Elbuluk M E Kankan M D | 1997 | IEEE Aerospace and Electronic Systems Magazine1997，12，5： | 1 |
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