|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclophosphamide-induced reproductive toxicity: Beneficial effects of Helichrysum odoratissimum(Asteraceae) in male Wistar rats显示文摘Objective: Cyclophosphamide(CP) is commonly used to treat some cancers, but its clinical efficacy is also linked with testicular toxicity. We investigated the effects of aqueous extract(AE) and methanolic extract(ME) of Helichrysum odoratissimum for reducing CP-induced reproductive toxicity in male rats.Methods: In addition to a normal control(group 1), drugs or vehicles were administered orally to seven groups(n = 5) of rats that had already received 4-weeks of pre-treatment with CP(5 mg/[kgád], per oral administration);group 2 received CP + distilled water(10 m L/[kgád]);group 3 received CP + 5% tween 80(10 m L/[kgád]);group 4 received CP + clomiphene citrate(0.25 mg/[kgád]);groups 5 and 6 received CP + AE(50 and 100 mg/[kgád]) and groups 7 and 8 received CP + ME(50 and 100 mg/[kgád]). Animals were sacrificed on day 15, and body and sexual organ weights, sperm characteristics, testosterone level and testicular histology were evaluated.Results: The CP-treated group showed a significant reduction(P < 0.001) in the body and seminal vesicle weights, testosterone level, sperm count, sperm motility and sperm viability, but elevated(P < 0.001)sperm morphological abnormalities and testicular structure alterations, compared to the control group.Interestingly, these detrimental effects of CP were reversed by treatment with H. odoratissimum extracts.For instance, both extracts and all doses of H. odoratissimum significantly increased the sperm count(P < 0.001), sperm motility(AE, 50 mg/kg, P < 0.05;ME, 50 and 100 mg/kg, P < 0.05) and sperm viability(AE, 50 mg/kg, P < 0.001;ME, 50 and 100 mg/kg, P < 0.001) compared to the CP group. H. odoratissimum also improved plasmatic and intratesticular testosterone levels and prevented histological alterations of the testes.Conclusion: H. odoratissimum might be considered as an alternative drug to alleviate/prevent reproductive damage in cancer patients receiving CP chemotherapy. | Pierre Watcho Ismaelle Rosine Mpeck Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Georges Romeo Bonsou Fozin Pierre Kamtchouing Albert Kamanyi | 2019 | Journal of Integrative Medicine2019，17，5： | 3 |
| 2 | Androgenic effect of Mondia whitei roots in male rats显示文摘Aim: To determine the effect of the aqueous extract of Mondia whitei (Periplocaceae) roots on testosterone production and fertility of male rats. Methods: Adult male Wistar rats were used. In the acute study, 20 rats were randomly divided into 5 groups of 4 animals each. Four treated groups were administered orally a single dose of Mondia whitei (400 mg/kg) and the controls received a similar amount of distilled water. One group of animals were sacrificed by cervical dislocation 1, 2, 4 and 6 h after treatment, respectively. The controls were sacrificed at 6 h.Testicular testosterone was determined by radioimmunoassay. In the chronic study, 28 rats were divided at random into 4 groups of 7 animals each: Groups 1, 2 and 3 were given orally the plant extract (400 mg·kg^-1·day^-1) for 2, 4 and 8 days, respectively. The animals of Groups 1 and 2 were sacrificed 24 hours after the last dosing. The controls (Group 4) received the same amount of distilled water for 8 days. The fertility was assessed only in Groups 3 and 4 and after that, the animals were sacrificed and the epididymal sperm density, the serum testosterone and the testicular testosterone and 17β-estradiol were assayed. The serum, testicular and epidydimal protein contents were also determined. Results: In the acute treatment groups, the serum and testicular concentrations of testosterone remained unchanged at all the time points. Chronic treatment for 8 days induced a significant increase in the testicular weight, the serum and testicular testosterone, the testicular protein content and the sperm density (P<0.05-0.01), but did not affect the accessory gland weights, the serum protein contents, the testicular concentration of 17β-estradiol and the fertility compared to the controls. Conclusion: Mondia whitei root extract possesses an androgenic property. (Asian J Androl 2004 Sep; 6: 269-272) | Pierre Watcho Pierre Kamtchouing Selestin D.Sokeng Paul F.Moundipa Justine Tantchou Jean L.Essame Noussithe Koueta | 2004 | Asian Journal of Andrology2004，6，3： | 2 |
| 3 | Antidiabetic and antioxidant effects of Annona muricata (Annonaceae), aqueous extract on streptozotocin-induced diabetic rats显示文摘 | Ngueguim Tsofack Florence Massa Zibi Benoit Kouamouo Jonas Tchuidjang Alexandra Dzeufiet Djomeni Paul Désiré Kamtchouing Pierre Dimo Théophile | 2014 | Journal of Ethnopharmacology2014，，2： | 2 |
| 4 | Effects of extracts from Hibiscus macranthus and Basella alba mixture on testosterone production in vitro in adult rat testes slices显示文摘瞄准:为了为生男性征的测量发现一个在试管内系统,芙蓉 macranthus (锦葵科) 和 Basella 白长袍的不同摘录完成一(Basellaceae ) 。方法:从片在二媒介,包含0.5%牛的血清白蛋白( BSA )的任何一个 Krebs-Henseleit 缓冲区或 Dubecco 孵化了的睾丸的睾丸激素的生产是修改的鹰的 medium-F12 火腿滋养的混合( DME/Ham F12 ),在5%的混合物下面,在95%空中的 CO2 也当面被决定或加 Basella 白长袍的余因子和芙蓉 macranthus 的缺席一( HMBA )摘录。结果:睾丸激素生产在在响应余因子(49%) 和水浸膏中等的 DME/Ham F12 孵化的睾丸片被增加(34%-60% 根据冲淡) 。在一样的大气的条件下面,没有到在 Krebs-Henseleit 的刺激缓冲包含 0.5% BSA 的余因子或 HMBA 摘录的睾丸片的积极反应。在与 HMBA 的效果有关的进一步的调查, DME/Ham F12 媒介被使用。从在试管内测试获得的结果证明这项活动在二氯甲烷和甲醇主要是在场的,自从这些摘录由睾丸片在睾丸激素生产导致了增加。结论:睾丸片系统是合适的被用于植物的生男性征的简历有功成分的隔离的进一步的在试管内调查。 | Paul E Moundipa Silvère Ngouela Pierre Kamtchouing Etienne Tsamo Félicité M.Tchouanguep Serge Carreau | 2006 | Asian Journal of Andrology2006，8，1： | 2 |
| 5 | Inhibition of Advanced Glycation End-Product Formation by Origanum majorana L. In Vitro and in Streptozotocin-Induced Diabetic Rats显示文摘 | Rosa Martha Perez Gutierrez Pierre Kamtchouing | 2012 | <journal-title>Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 6 | Clinical features and epidemiology of cutaneous leishmaniasis and Leishmania major /HIV co-infection in Cameroon: results of a large cross-sectional study显示文摘 | Omer Bébé Ngouateu Pierre Kollo Christophe Ravel Jacques Dereure Pierre Kamtchouing Albert Same-Ekobo Esther von Stebut Marcus Maurer Blaise Dondji | 2011 | Transactions of the Royal Society of Tropical Medicine and Hygiene2011，，3： | 1 |
| 7 | Hypotensive effects of a methanol extract of Bidens pilosa Linn on hypertensive rats显示文摘 | Dimo T Nguelefack T B Kamtchouing P | 1999 | Comptes Rendus De L ''académie Des Sci1999，322，4： | 1 |
| 8 | Sexuality of adolescent s tudents in Yaounde显示文摘 | Kamtchouing P Takougang I Ngoh N | 1997 | Contracept Fertil Sex1997，25，10： | 1 |
| 9 | Age-related changes in the function of the pituitary- gonadal axis in a sterile male rat mutant (hd/hd) 显示文摘 | Kamtchouing P Hochereau de Reviers MT Perreau C | 1991 | Biol Reprod1991，45，1： | 1 |
| 10 | Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats显示文摘Objective: Infectious diseases such as typhoid fever lead to the formation of free radicals which can damage the body. Many medicinal plants have antioxidant molecules that neutralize free radicals. The present work evaluated the antioxidant activity and histopathological effects of the dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats.Methods: The S. typhi-infected rats concurrently received daily doses of D. integrifolia extract at doses of 25, 50 and 100 mg/kg body weight or ciprofloxacin(5 mg/kg body weight) for 15 days. Body temperature was measured daily during infection and treatment periods. At the end of treatment period, the animals were sacrificed and biological responses including hematological parameters, superoxide dismutase and catalase activities, and glutathione, malondialdehyde and nitric oxide concentrations were evaluated.Results: The elevated body temperature induced by infection was significantly decreased in animals treated with 25, 50 or 100 mg/kg of the extract. Platelet levels decreased slightly in infected rats, while treatment with the dichloromethane fraction of D. integrifolia significantly increased platelet levels;this response was greater than that elicited by ciprofloxacin. The doses of 50 and 100 mg/kg of the dichloromethane fraction of D. integrifolia notably decreased monocyte and neutrophil values. Activity of superoxide dismutase and catalase and levels of glutathione in the tissues of treated animals were increased significantly(P < 0.01), while malondialdehyde and nitric oxide levels were significantly decreased(P < 0.01), following treatment with the dichloromethane fraction of D. integrifolia.Conclusion: The results of this study show that the dichloromethane fraction of D. integrifolia has protective effects against a series of pathological conditions initiated by oxidation and tissue damage in the course of a S. typhi infection. | Gaetan Olivier Fankem Michel Archange Fokam Tagne Paul Aime Noubissi Angèle Foyet Fondjo Idrice Kamtchouing Adela Ngwewondo Henri Wambe Joseph Ngakou Mukam Rene Kamgang | 2019 | Journal of Integrative Medicine2019，17，6： | 0 |
| 11 | Aframomum melegueta prevents the ejaculatory complications of propylthiouracil-induced hypothyroidism in sexually experienced male rats: Evidence from intravaginal and fictive ejaculations显示文摘Objective: Hypothyroidism has been claimed to generate sexual dysfunctions such as ejaculatory disorders. Aframomum melegueta is an aphrodisiac plant with pro-ejaculatory properties. We investigated the protective effects of aqueous extract(AE) and methanolic extract(ME) of A. melegueta on the ejaculatory function of hypothyroid male rats.Methods: Forty sexually experienced male rats were partitioned into 8 groups(5 rats per group) and treated for 28 d as follows: Group 1, Control;Group 2, propylthiouracil(PTU, 10 mg/kg)+ distilled water(DW,10 m L/kg);Group 3, PTU + 5% Tween 80(10 m L/kg);Group 4, PTU + bromocriptine(6 mg/kg);Group 5,PTU + AE(20 mg/kg);Group 6, PTU + AE(100 mg/kg);Group 7, PTU + ME(20 mg/kg), and Group 8,PTU + ME(100 mg/kg). On days 0, 7, 14 and 28 of treatment, each male rat was paired with primed receptive female for measurement of ejaculatory latency time(ELT) and post-ejaculatory interval(PEI) for1.5 h. On day 29, each male rat was urethane-anesthetized and the spinal cord was transected.Thereafter, following urethral/penile stimulations and intravenous injection of dopamine, contractions of the bulbospongiosus muscles and the intraseminal pressure were registered. After these recordings,blood was collected through the catheterization of abdominal artery and plasma was used for thyroidstimulating hormone(TSH), prolactin and testosterone assays.Results: PTU-induced hypothyroidism was characterized by a significant elevation(P < 0.001) of plasmatic TSH and prolactin levels, but a decline(P < 0.001) in plasmatic testosterone, compared to untreated group. ELT, PEI, contractions of the bulbospongiosus muscles and the intraseminal pressure were also altered by PTU treatment. On the contrary, A. melegueta extracts elevated testosterone(AE, 100 mg/kg,P < 0.01;ME, 100 mg/kg, P < 0.05) and decreased prolactin(AE, 100 mg/kg, P < 0.05;ME, 20 mg/kg,P < 0.05) levels, compared to corresponding controls. With regard to DW + PTU group, prolactin concentration was lowered(P < 0.05) in rats administered with bromocriptine. Treatment with A. melegueta extracts significantly prevented the lengthening of ELT(P < 0.05) and PEI(P < 0.001). Hypothyroid state also altered the fictive ejaculation by increasing the latency and decreasing the number and frequency of bulbospongiosus muscle contractions. There was also a decrease in the intraseminal pressure. These alterations were significantly(P < 0.05) alleviated in plant extract-treated groups.Conclusion: This study highlighted the ejaculatory disturbance of hypothyroidism in male rats and its prevention with A. melegueta extracts. | Francois Xavier Kemka Nguimatio Patrick Brice Deeh Defo Modeste Wankeu-Nya Esther Ngadjui Albert Kamanyi Pierre Kamtchouing Pierre Watcho | 2019 | Journal of Integrative Medicine2019，17，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员