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| 1 | Liver transplantation for hepatocellular carcinoma:an update显示文摘BACKGROUND: Hepatocellular carcinoma (HCC) is a heterogeneous malignancy with multiple etiologies, high incidence, and high mortality. The standard surgical management for patients with HCC consists of locoregional ablation, surgical resection, or liver transplantation, depending on the background state of the liver. Eighty percent of patients initially presenting with HCC are unresectable, either due to the extent of tumor or the level of underlying hepatic dysfunction. While in patients with no evidence of cirrhosis and good hepatic function resection has been the surgical treatment of choice, it is contraindicated in patients with moderate to severe cirrhosis. Liver transplantation is the optimal surgical treatment. DATA SOURCES: PubMed search of recent articles (from January 2000 to March 2011) was performed looking for relevant articles about hepatocellular carcinoma and its treatment. Additional articles were identified by evaluating references from selected articles. RESULTS: Here we review criteria for transplantation, the types, indications, and role of locoregional therapy in treating the cancer and in downstaging for possible later transplantation. We also summarize the contribution of immunosuppression and adjuvant chemotherapy in the management and prevention of HCC recurrence. Finally we discuss recent advances in imaging, tumor biology, and genomics as we delineate the remaining challenges for the diagnosis and treatment of this disease. CONCLUSIONS: Much can be improved in the diagnosis and treatment of HCC. A great challenge will be to improve patient selection to criteria based on tumor biology. Another will be to incorporate systemic agents post-operatively in patients at high risk for recurrence, paying close attention to efficacy and safety. The future direction of the effort in treating HCC will be to stimulate prospective trials, develop molecular imaging of lymphovascular invasion, to improve recipient selection, and to investigate biomarkers of tumor biology. | Ali Zarrinpar Fady Kaldas Ronald W Busuttil | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 8 |
| 2 | 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia显示文摘 | Dinesh Khanna John D. Fitzgerald Puja P. Khanna Sangmee Bae Manjit K. Singh Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 4 |
| 3 | Liver Transplantation in Highest Acuity Recipients: Identifying Factors to Avoid Futility显示文摘 | Henrik Petrowsky Abbas Rana Fady M. Kaldas Anuj Sharma Johnny C. Hong Vatche G. Agopian Francisco Durazo Henry Honda Jeffrey Gornbein Victor Wu Douglas G. Farmer Jonathan R. Hiatt Ronald W. Busuttil | 2014 | Annals of Surgery2014，，6： | 2 |
| 4 | Liver Transplantation for Nonalcoholic Steatohepatitis: The New Epidemic显示文摘 | Vatche G. Agopian Fady M. Kaldas Johnny C. Hong Meredith Whittaker Curtis Holt Abbas Rana Ali Zarrinpar Henrik Petrowsky Douglas Farmer Hasan Yersiz Victor Xia Jonathan R. Hiatt Ronald W. Busuttil | 2012 | Annals of Surgery2012，，4： | 2 |
| 5 | Liver Transplantation for Nonalcoholic Steatohepatitis: The New Epidemic显示文摘 | Vatche G. Agopian Fady M. Kaldas Johnny C. Hong Meredith Whittaker Curtis Holt Abbas Rana Ali Zarrinpar Henrik Petrowsky Douglas Farmer Hasan Yersiz Victor Xia Jonathan R. Hiatt Ronald W. Busuttil | 2012 | Annals of Surgery2012，，4： | 2 |
| 6 | 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis显示文摘 | Dinesh Khanna Puja P. Khanna John D. Fitzgerald Manjit K. Singh Sangmee Bae Tuhina Neogi Michael H. Pillinger Joan Merill Susan Lee Shraddha Prakash Marian Kaldas Maneesh Gogia Fernando Perez‐Ruiz Will Taylor Frédéric Lioté Hyon Choi Jasvinder A. Singh Ni | 2012 | Arthritis Care Res2012，，10： | 2 |
| 7 | Effect of upper extremity exer- cise on secondary lymphedema in breast cancer patients: a pi- lot study 显示文摘 | McKenzie D C Kalda A L | 2003 | J Clln Chacol2003，21，3： | 1 |
| 8 | Predictive Index for Long-Term Survival After Retransplantation of the Liver in Adult Recipients: Analysis of a 26-Year Experience in a Single Center显示文摘 | Johnny C. Hong Fady M. Kaldas Prawat Kositamongkol Henrik Petrowsky Douglas G. Farmer Daniela Markovic Jonathan R. Hiatt Ronald W. Busuttil | 2011 | Annals of Surgery2011，，3： | 1 |
| 9 | Histone deacetylase inhibitors modulates the induction and expression of amphetamine - induced behavioral sensitization partially through an associated learning of the environment in mice 显示文摘 | Kalda A Heidmets LT Shen HY | 2007 | Behav Brain Res2007，181，： | 1 |
| 10 | Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia-repefusion injury显示文摘 | Tsuchihashi S Ke B Kaldas F | 2006 | Am J Pathol2006，168，2： | 1 |
| 11 | Vascular Endothelial Growth Factor Antagonist Modulates Leukocyte Trafficking and Protects Mouse Livers against Ischemia/Reperfusion Injury显示文摘 | Sei-ichiro Tsuchihashi Bibo Ke Fady Kaldas | 2006 | American Journal of Pathology2006，168，： | 1 |
| 12 | Reproduction and General Metabolic Effects of Phytoestrogens in Mammals 显示文摘 | Kaldas R S | 1989 | Reproductive Toxicology1989，3，2： | 1 |
| 13 | Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury 显示文摘 | Tsuchihashi S Ke B Kaldas F | 2006 | Am J Pathol2006，168，2： | 1 |
| 14 | HYPERLIPIDEMIA AFTER LIVER TRANSPLANTATION: Natural History and Treatment with the Hydroxy-Methylglutaryl-Coenzyme A Reductase Inhibitor Pravastatin1显示文摘 | David K. Imagawa Sherfield Dawson Curtis D. Holt Pamela S. Kirk Fady M. Kaldas Christopher R. Shackleton Philip Seu Steve M. Rudich Milan M. Kinkhabwala Paul Martin Leonard I. Goldstein Natalie G.B. Murray Paul I. Terasaki Ronald W. Busuttil | 1996 | Transplantation1996，，7： | 1 |
| 15 | Vascular endothelial growth factor antagonist modulates leukocyte trafficking and protects mouse livers against ischemia/reperfusion injury 显示文摘 | Tsuchihashi S Ke B Kaldas F | 2006 | Am J Pathol2006，168，2： | 1 |
| 16 | A new animal model of throm- hophilia confirms that high plasma levels of Foctor Ⅷ levels are thrombogenic 显示文摘 | Kawa sakl T Kalda T Arnout J | 1999 | Thromb Haemost1999，81，： | 1 |
| 17 | A novel inducible nitric oxide synthase inhibitor,prevents ischemia and reperfusion injury in rat liver transplantation 显示文摘 | Tsuchihashi SA Kaldas FA Chida N | 2006 | American Journal of Transplantation2006，6，9： | 1 |
| 18 | Quality im- provement in the Estonian health system-assessment of progress us- ing an intenmtional tool显示文摘 | KAJA Polluste JARNO Habicht RUTtt Kalda | 2006 | International Journal for Quality in Health Care2006，18，6： | 1 |
| 19 | Predictive index for tumor recurrence after liver transplantation for locally advanced intrahepatie and hilar eholangiocareinoma 显示文摘 | Hong JC Petrowsky H Kaldas FM | 2011 | J Am Coil Surg2011，212，4： | 1 |
| 20 | Reproductive and general metabolic effects of phytoestrogens in mammals显示文摘 | Kaldas R S Hughes C L | 1989 | Reprod Toxical1989，3，： | 1 |
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