|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of the Urinary Tryptin Inhibitor Ulinastatin on Cardiopulmonary Bypass–Related Inflammatory Response and Clinical Outcomes: A Meta-Analysis of Randomized Controlled Trials显示文摘 | Siyi He Kailong Lin Ruiyan Ma Rufu Xu Yingbin Xiao | 2015 | Clinical Therapeutics2015，，3： | 1 |
| 2 | Developmental expression of amphioxus GABAA receptor-associated protein-like 2 gene显示文摘 | Kailong Liang Yushuang Lin Yanjun Zhang Zhongke Chen Peijun Zhang Hongwei Zhang | 2004 | Development Genes and Evolution2004，，7： | 1 |
| 3 | Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition显示文摘Inositol-requiring enzyme 1α(IRE1α)is the most conserved endoplasmic reticulum(ER)stress sensor with two catalytic domains,kinase and RNase,in its cytosolic portion.IRE1αinhibitors have been used to improve existing clinical treatments against various cancers.In this study we identified toxoflavin(TXF)as a new-type potent small molecule IRE1αinhibitor.We used luciferase reporter systems to screen compounds that inhibited the IRE1α-XBP1s signaling pathway.As a result,TXF was found to be the most potent IRE1αRNase inhibitor with an IC50 value of 0.226μM.Its inhibitory potencies on IRE1αkinase and RNase were confirmed in a series of cellular and in vitro biochemical assays.Kinetic analysis showed that TXF caused time-and reducing reagent-dependent irreversible inhibition on IRE1α,implying that ROS might participate in the inhibition process.ROS scavengers decreased the inhibition of IRE1αby TXF,confirming that ROS mediated the inhibition process.Mass spectrometry analysis revealed that the thiol groups of four conserved cysteine residues(CYS-605,CYS-630,CYS-715 and CYS-951)in IRE1αwere oxidized to sulfonic groups by ROS.In molecular docking experiments we affirmed the binding of TXF with IRE1α,and predicted its binding site,suggesting that the structure of TXF itself participates in the inhibition of IRE1α.Interestingly,CYS-951 was just near the docked site.In addition,the RNase IC50 and ROS production in vitro induced by TXF and its derivatives were negative correlated(r=−0.872).In conclusion,this study discovers a new type of IRE1αinhibitor that targets a predicted new alternative site located in the junction between RNase domain and kinase domain,and oxidizes conserved cysteine residues of IRE1αactive sites to inhibit IRE1α.TXF could be used as a small molecule tool to study IRE1α’s role in ER stress. | Kailong Jiang Chang-mei Liu Li-tong Nie Hai-ni Jjang Lei Xu Kun-zhi Zhang Li-xia Fan An-hui Gao Lu-ling Lin Xiang-yu Wang Ming-jia Tan Qi-qing Zhang Yu-bo Zhou Jia Li | 2023 | Acta Pharmacologica Sinica2023，44，1： | 0 |
| 4 | Unrolling a rain-guided detail recovery network for single-image deraining显示文摘Background Owing to the rapid development of deep networks, single-image deraining tasks have progressed significantly. Various architectures have been designed to recursively or directly remove rain, and most rain streaks can be removed using existing deraining methods. However, many of them cause detail loss, resulting in visual artifacts. Method To resolve this issue, we propose a novel unrolling rain-guided detail recovery network(URDRN) for single-image deraining based on the observation that the most degraded areas of a background image tend to be the most rain-corrupted regions. Furthermore, to address the problem that most existing deep-learningbased methods trivialize the observation model and simply learn end-to-end mapping, the proposed URDRN unrolls a single-image deraining task into two subproblems: rain extraction and detail recovery. Result Specifically, first, a context aggregation attention network is introduced to effectively extract rain streaks;thereafter, a rain attention map is generated as an indicator to guide the detail recovery process. For the detail recovery sub-network, with the guidance of the rain attention map, a simple encoder–decoder model is sufficient to recover the lost details.Experiments on several well-known benchmark datasets show that the proposed approach can achieve performance similar to those of other state-of-the-art methods. | Kailong LIN Shaowei ZHANG Yu LUO Jie LING | 2023 | Virtual Reality & Intelligent Hardware2023，5，1： | 0 |
| 5 | Impact of different organic matters on the occurrence of antibiotic resistance genes in activated sludge显示文摘The occurrence of antibiotic resistance genes(ARGs)in various environments has drawn worldwide attention due to their potential risks.Previous studies have reported that a variety of substances can enhance the occurrence and dissemination of ARGs.However,few studies have compared the response of ARGs under the stress of different organicmatters in biologicalwastewater treatment systems.In this study,seven organic pollutantswere added into wastewater treatment bioreactors to investigate their impacts on the ARG occurrence in activated sludge.Based on high-throughput sequencing,it was found that the microbial communities and ARG patterns were significantly changed in the activated sludge exposed to these organic pollutants.Compared with the non-antibiotic refractory organic matters,antibiotics not only increased the abundance of ARGs but also significantly changed the ARG compositions.The increase of Gram-negative bacteria(e.g.,Archangium,Prosthecobacter and Dokdonella)carrying ARGs could be the main cause of ARG proliferation.In addition,significant co-occurrence relationships between ARGs and mobile genetic elements were also observed in the sludge samples,which may also affect the ARG diversity and abundance during the organic matter treatment in the bioreactors.Overall,these findings provide new information for better understanding the ARG occurrence and dissemination caused by organic pollutants in wastewater treatment systems. | Xiuwen Zhang Suwan Liu Haohao Sun Kailong Huang Lin Ye | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 6 | An integrated machine learning model for accurate and robust prediction of superconducting critical temperature显示文摘Discovering new superconductors via traditional trial-and-error experimental approaches is apparently a time-consuming process,and the correlations between the critical temperature(Tc) and material features are still obscure.The rise of machine learning(ML) technology provides new opportunities to speed up inefficient exploration processes,and could potentially uncover new hints on the unclear correlations.In this work,we utilize open-source materials data,ML models,and data mining methods to explore the correlation between the chemical features and Tcvalues of superconducting materials.To further improve the prediction accuracy,a new model is created by integrating three basic algorithms,showing an enhanced accuracy with the coefficient of determination(R2) score of 95.9 % and root mean square error(RMSE) of 6.3 K.The average marginal contributions of material features towards Tcvalues are estimated to determine the importance of various features during prediction processes.The results suggest that the range thermal conductivity plays a critical role in Tcprediction among all element features.Furthermore,the integrated ML model is utilized to screen out potential twenty superconducting materials with Tcvalues beyond 50.0 K.This study provides insights towards Tcprediction to accelerate the exploration of potential high-Tcsuperconductors. | Jingzi Zhang Ke Zhang Shaomeng Xu Yi Li Chengquan Zhong Mengkun Zhao Hua-Jun Qiu Mingyang Qin X.-D.Xiang Kailong Hu Xi Lin | 2023 | Journal of Energy Chemistry2023，，3： | 0 |
| 7 | 2-3 Lifetime Measurement of the First 7/2^+State in 143Eu Based on Gas-flled Spectroscopy显示文摘The application of Lanthanum Bromide(LaBr3)detectors provides a unique opportunity to measure lifetime of excited states in picosecond-nanosecond region.Reducing the background is of critical importance to get precise results.For some excited states feeding from isomers with lifetime longer than 1μs,it can be achieved by the Spectrometer for Heavy Atom and Nuclear Structure(SHANS)[1].143Eu nuclei were populated via the 123Sb(24Mg,4n)fusion-evaporation reaction.Most of the evaporation residues at ground state or long-lived isomers were transferred to detection terminal after a flight of about 1.4μs in SHANS.In the case of 143Eu,three transitions have been observed(Fig.1). | Guo Song Wang Kailong Liu Minliang Zheng Yong Zhou Xiaohong Wang Jianguo Qiang Yunhua Zhang Yuhu Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Ding Bing Jiang Jian Fang Yongde Li Guangshun Zheng Kuankuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 8 | Enhanced bifunctional catalytic activities of N-doped graphene by Ni in a 3D trimodal nanoporous nanotubular network and its ultralong cycling performance in Zn-air batteries显示文摘Free-standing and fexible air electrodes with long-lasting bifunctional activities for both the oxygen reduction reaction(ORR)and the oxygen evolution reaction(OER)are crucial to the development of wearable Zn-air rechargeable batteries.In this work,we synthesize a fexible air electrode consisting of 3D nanoporous N-doped graphene with trimodal shells and Ni particles through repeated chemical vapor deposition(CVD)and acidic etching processes.Our results indicate that such trimodal graphene morphology significantly enhances the active N-dopant sites and graphene-coated Ni surface,which consequentially boosts both the ORR and OER activities,as well as catalytic durability.First-principles density functional theory(DFT)calculations reveal the synergetic effects between the Ni and the N-doped graphene;namely,the Ni nanoparticles boost the bifunctional activities of the coated N-doped graphene,and in turn the graphene-covering layers enhance the stability of Ni.Thanks to the better protection from the triple graphene shells,our trimodal N-doped graphene/Ni-based Zn-air battery can be stably discharged/recharged beyond 2500 h with low overpotentials.It is reasonable to expect that such freestanding trimodal graphene/Ni would be promising in many fexible energy conversion/storage devices. | Yanyi Zhang Xiang-Peng Kong Xiaorong Lin Kailong Hu Weiwei Zhao Guoqiang Xie Xi Lin Xingjun Liu Yoshikazu Ito Hua-Jun Qiu | 2022 | Journal of Energy Chemistry2022，31，3： | 0 |
| 9 | 2-22 Fine Structure in theαDecay of 223U显示文摘Isotope 223U synthesized and identified[1;2].αenergy of 8 780(40)keV and a half-life of 55(10)μs.Theαenergy was calculated by subtracting knownαenergy of 219Th from measured decay sum energy of 223U and its daughter 219Th.Based on the advanced digital pulse processing technique,a new measurement forα-particle energy and half-life of 223U was performed at the gas-filled recoil separator,Spectrometer for Heavy Atoms and Nuclear Structure(SHANS).The isotope 223U was produced in the fusion-evaporation reaction 187Re(40Ar,p3n)223U. | Sun Mingdao Liu Zhong Huang Tianheng Zhang Wenqiang Wang Jianguo Liu Xiaoyu Ding Bing Gan Zaiguo Ma Long Yang Huabing Zhang Zhiyuan Yu Lin Jiang Jian Wang Kailong Wang Yongsheng Liu Minliang Li Zhihuan Li Jing Wang Xiang Lu Hongyang Lin Chenjian Sun Lijie Ma Nanru Yuan Cenxi Zuo Wei Xu Hushan Zhou Xiaohong Xiao Guoqing | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 10 | 2-2 Lifetime Measurements of the Low-lying Excited States in 87 Zr and 87 Nb显示文摘Lifetime measurements of low-lying excited states in 87Zr and 87Nb have been performed via and coincidences. The 124 MeV 32S beam was delivered from the Sector-Focusing Cyclotron (SFC) of the Heavy Ion R-esearch Facility in Lanzhou (HIRFL). The parent nuclei 87Nb and 87Mo were produced by the respective reactions 58Ni (32S, 3p) and 58Ni (32S, 2p1n), at a beam energy 100 MeV through the 8 m Al degrader. | Qiang Yunhua Liu Minliang Zhou Xiaohong Wang Jianguo Wang Kailong Lv Bingfeng Zheng Yong Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Jiang Jian Sun Mingdao | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 11 | 2-14 Production of New Nuclides 216U and 215U显示文摘The study on the decay properties of new isotopes located far from the beta stability line is current the focus of nuclear physics. For isotopes in the region Z >82 and N <126, -emission prevails as radioactive decay mode and -spectroscopy is the most important tool to obtain information on the nuclear structure. In the heavy nuclei region with N=124 and 126 isotones, an intruder state (h9=2.f7=2)8+ based on the attractive interaction of f7=2 protons and f5=2 neutrons has been significantly observed, which increases the binding energy of this configuration with increasing proton number. | Yang Huabin Gan Zaiguo Zhang Zhiyuan Ma Long Yu Lin Jiang Jian Wang Jianguo Tian Yulin Wang Yongsheng Ding Bing Sun Mingdao Huang Tianheng Wang Kailong | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员