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| 1 | Effect of cigarette smoking and alcohol consumption in the etiology of cancer of the oral cavity,pharynx and larynx显示文摘 | Choi SY Kahyo H | 1991 | Int J Epidemiol1991，20，： | 1 |
| 2 | A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells显示文摘 | Kahyo T Ichikawa S Hatanaka T | 2008 | J Pharmacol Sci2008，108，3： | 1 |
| 3 | Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization显示文摘 | Shin‐ichiro Kiyose Kiyoko Nagura Hong Tao Hisaki Igarashi Hidetaka Yamada Masanori Goto Matsuyoshi Maeda Nobuya Kurabe Masaya Suzuki Masaru Tsuboi Tomoaki Kahyo Kazuya Shinmura Naohiko Hattori Haruhiko Sugimura | 2012 | Pathology International2012，，7： | 1 |
| 4 | Effect of cigarette smoking and alcohol consumption in the aetiology of cancer of the oral cavity,pharynx and larynx显示文摘 | Choi SY Kahyo H | | 0，，04： | 1 |
| 5 | Sirtuin-mediated deacetylation pathway stabilizes Wemer syndrome protein 显示文摘 | Kahyo T Mostoslavsky R Goto M | 2008 | FEBS Lett2008，582，17： | 1 |
| 6 | Effect of cigarette smoking and alcohol consumption in the etiology of cancer of the digestive tract 显示文摘 | Choi SY Kahyo H | 1991 | Int J Cancer1991，49，3： | 1 |
| 7 | Sirtuin-mediated deacetylation pathway stabilizes Wemer syndrome protein显示文摘 | Kahyo T Mostoslavsky R Goto M | 2008 | FEBS Lett2008，582，17： | 1 |
| 8 | Involvement of PIAS1 in the sumoylation of tumor suppressor p53 显示文摘 | KAHYO T NISHIDA T YASUDA H | 2001 | Mol Cell2001，8，： | 1 |
| 9 | Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry显示文摘 | Nobuya Kurabe Takahiro Hayasaka Hisaki Igarashi Hiroki Mori Keigo Sekihara Hong Tao Hidetaka Yamada Tomoaki Kahyo Ippei Onishi Hiroe Tsukui Akikazu Kawase Shun Matsuura Yusuke Inoue Kazuya Shinmura Kazuhito Funai Mitsutoshi Setou Haruhiko Sugimura | 2013 | Pathol Int2013，，： | 1 |
| 10 | Sirtuln - mediated deaeetylatian pathway sta- bilizes Werner syndrome protein 显示文摘 | Kahyo T Mostoslavsky R Goto M | 2005 | FEBS Lett2005，582，17： | 1 |
| 11 | Effect of cigarette smoking and alcohol consumption in the etiology of cancer of the oral cavity,pharynx and larynx 显示文摘 | Choi SY Kahyo H | 1991 | Int J Epidemiol1991，49，3： | 1 |
| 12 | Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway显示文摘 | Hidetaka Ota Masato Eto Mitsunobu R. Kano Tomoaki Kahyo Mitsutoshi Setou Sumito Ogawa Katsuya Iijima Masahiro Akishita Yasuyoshi Ouchi | 2010 | Arteriosclerosis Thrombosis and Vascular Biology2010，，11： | 1 |
| 13 | Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT 4显示文摘 | Nobuya Kurabe Takahiro Hayasaka Mikako Ogawa Noritaka Masaki Yoshimi Ide Michihiko Waki Toshio Nakamura Kiyotaka Kurachi Tomoaki Kahyo Kazuya Shinmura Yutaka Midorikawa Yasuyuki Sugiyama Mitsutoshi Setou Haruhiko Sugimura | 2013 | Cancer Sci2013，，： | 1 |
| 14 | EPH-EPHRIN in human gastrointestinal cancers显示文摘Ever since its discovery two decades ago,the erythro- poietin-producing hepatoma (EPH)-EPHRIN system has been shown to play multifaceted roles in human gastroenterological cancer as well as neurodevelopment.Overexpression,amplif ication and point mutations have been found in many human cancers and many investigators have shown correlations between these up-regulationsand tumor angiogenesis.Thus,the genes in this family are considered to be potential targets of cancer therapy.On the other hand,the down-regulation of some members as a result of epigenetic changes has also been reported in some cancers.Furthermore,the correlation between altered expressions and clinical prognosis seems to be inconclusive.A huge amount of protein-protein interaction studies on the EPH-EPHRIN system have provided a basic scheme for signal transductions,especially bi-directional signaling involving EPH-ERPHRIN molecules at the cell membrane.This information also provides a manipulative strategy for harnessing the actions of these molecules.In this review,we summarize the known alterations of EPH-EPHRIN genes in human tumors of the esophagus,stomach,colorectum,liver and pancreas and present the perspective that the EPH-EPHRIN system could be a potential target of cancer therapy. | Haruhiko Sugimura Hiroki Mori Masaru Tsuboi Kiyoko Nagura Hisaki Igarashi Ritsuko Nakamura Hiroko Natsume Tomoaki Kahyo Kazuya Shinmura Hiroyuki Konno Yasushi Hamaya Shigeru Kanaoka Hideki Kataoka | 2010 | World Journal of Gastrointestinal Oncology2010，2，12： | 0 |
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