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| 1 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 2 | A 1 year follow-up study of the consequences of helicobacter pylori eradication in duodenal ulcer patients:unchanged frequency of erosive oesophagitis and decreased prevalence of non-erosive gastro-oesophageal reflux disease显示文摘 | Kupcinskas L Jonaitis L Kiudelis G | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 3 | Clinical trial: randomized-controlled clinical study comparing the efficacy and safety of a low-volume vs a high-volume mesalazine foam in active distal ulcerative colitis显示文摘 | ELIAKIM R TULASSAY Z KUPCINSKAS L | 2007 | Aliment Pharmacol2007，26，： | 1 |
| 4 | Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers 显示文摘 | Agreus L Kuipers E J Kupcinskas L | 2012 | Scand J Gastroenterol2012，47，2： | 1 |
| 5 | Laryngeal examination is superior to endoscopy in the diagnosis of the laryngopharyngeal form of gastroesophageal reflux disease 显示文摘 | Jonaitis L Pribuisiene R Kupcinskas L | 2006 | Scand J Gastroenterol2006，41，2： | 1 |
| 6 | The validity of a biomar- ker method for indirect detection of gastric mucosal atrophy versus standard histopathology 显示文摘 | Leja M Kupcinskas L Funka K | 2009 | Dig Dis Sci2009，54，11： | 1 |
| 7 | Diagnostic sensitivity and specificity of laryngoscopic signs of reflux laryngitis 显示文摘 | Pribuisiene R Uloza V Kupcinskas L | 2008 | Medicina (Kaunas)2008，44，4： | 1 |
| 8 | Prognostic factors for short and long-term survival in patients selected for liver transplantation显示文摘 | Sumskiene J Kupcinskas L Pundzius J | 2005 | Medicina(Kaunas)2005，41，1： | 1 |
| 9 | , Interleukin-lB and interleukin-1 receptor antagonist gene polymorphisms are not associ- ated with premalignant gastric conditions: a combined haplotype analysis显示文摘 | Kupcinskas L Wex T Kupcinskas J | 2010 | EurJ Gastroenterol Hepatol2010，22，10： | 1 |
| 10 | Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma bio- markers显示文摘 | AgrSus L Kuipers E J Kupcinskas L | 2012 | Scand J Gastreenterel2012，47，2： | 1 |
| 11 | Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy显示文摘 | Kondrackiene J Beuers U Kupcinskas L | 2005 | Gastroenterology2005，129，3： | 1 |
| 12 | Laryngeal ex- amination is superior to endoscopy in the diagnosis of the la- ryngopharyngeal form of gastroesophageal reflux disease显示文摘 | Jonaitis L Pribuisiene R Kupcinskas L | 2006 | Seand J Gastroenterol2006，41，： | 1 |
| 13 | Charaeteristics of patients willl erosive and nonerosive GERD in high-helicobacter-pylori preva- lence regien 显示文摘 | Jonaitis LV Kiudelis G Kupcinskas L | 2004 | Dis Esophagus2004，17，3： | 1 |
| 14 | De novo erosive esophagi- tis in duodenal ulcer patients related to pre - existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication : a one - year follow - up study 显示文摘 | Jonaitis L Kupcinskas J Kiudelis G | 2010 | Medicina ( Kaunas)2010，46，7： | 1 |
| 15 | A I year follow-up study of the consequences of helicobacter pylori eradication in duodenal ulcer patients:unchanged frequency of erosive oesophagitis and decreased prevalence of non-erosive gastroesophageal reflux disease显示文摘 | Kupcinskas L JonaitisL Kiudelis G | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 16 | Liver diseases unique topregnan-cy显示文摘 | Kondrackiene J Kupcinskas L | 2008 | Medicina(Kaunas)2008，44，5： | 1 |
| 17 | Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy显示文摘 | Kondrackiene J Beuers U Kupcinskas L | 2005 | Gastroenterology2005，129，3： | 1 |
| 18 | Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy显示文摘 | Kondrackiene J Beuers U Kupcinskas L | 2005 | Gastroenterology2005，129，3： | 1 |
| 19 | Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients:a one-year follow-up study显示文摘 | Jonaitis L Kiudelis G Kupcinskas L | 2008 | Medicina(Kaunas)2008，44，3： | 1 |
| 20 | Gastroesophageal reflux disease after Helicobacter pylorieradication in gastric ulcer patients:a one-year follow-up study显示文摘 | Jonaitis L Kiudelis G Kupcinskas L | 2008 | Medicina(Kaunas)2008，44，3： | 1 |
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