| 1 | Imaging-Based Characterization of Perthite in the Upper Triassic Yanchang Formation Tight Sandstone of the Ordos Basin,China显示文摘This work investigated the element distribution of perthite from the Upper Triassic Yanchang Formation tight sandstone in the Ordos Basin of northern China by field emission scanning electron microscopy(FE-SEM) and energy dispersive spectrometer(EDS). FE-SEM results indicate significant differences in the morphology of Na-rich feldspar when K-rich feldspar is the main component of the perthite. EDS results show that different types of perthite have clearly defined differences on different element indexes. Additionally, indexes such as average-weight-K(K-rich)/Na(Na-rich), maximumweight-K(Na-rich)/Na(Na-rich) and average-atomic-K(K-rich)/Na(Na-rich) might be the most effective ones to identify perthite types. Perthite is divided into six main types, i.e., perthite with thick parallel stripe distribution, with thin parallel stripe distribution, with lumpy stripe distribution, with dendritic stripe distribution, with encircling stripe distribution, and with mixed stripe distribution. | DU Shuheng SHI Guoxin YUE Xinjian KOU Gen ZHOU Bo SHI Yongmin | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 2 |
| 2 | 3-溴丙酮酸对秀丽隐杆线虫的毒性和代谢的影响(英文)显示文摘目的:通过3-溴丙酮酸(3-BrPA)处理秀丽隐杆线虫(Caenorhabditis elegans),观察3-BrPA对线虫的毒性和生存周期的影响。通过秀丽隐杆线虫RNA干扰(RNAi)和突变株,分析3-BrPA对线虫糖酵解途径己糖激酶家族和药物代谢的关键酶细胞色素P450(cytochrome P450,CYP)家族的影响。创新点:首次报道了3-BrPA对秀丽隐杆线虫有毒性作用,己糖激酶是3-BrPA对线虫作用的重要靶点,而CYP-35A家族是线虫代谢3-BrPA的主要酶类。方法:用不同浓度的3-BrPA处理秀丽隐杆线虫,每24 h监测一次存活率;用实时荧光定量聚合酶链反应(qPCR)检测代谢相关基因的表达;通过RNAi沉默己糖激酶家族基因hxk-1、hxk-2和hxk-3;计算3-BrPA处理hxk家族RNAi株和细胞色素P450 cyp-35家族突变株后的致死中浓度(LC50)。结论:3-BrPA对线虫有明显的毒性效应(图1);与对照组比较,3-BrPA处理组的线虫平均寿命明显缩短(图2);3-BrPA处理线虫后hxk-1、hxk-2和hxk-3的信使RNA(mRNA)表达明显升高(P<0.05,图5);3-BrPA处理hxk RNAi株后的LC50均减小(P<0.05,表5);3-BrPA处理cyp-35突变株后的LC50也均减小(P<0.05,表6)。综上所述,3-BrPA的毒性与其对秀丽隐杆线虫己糖激酶代谢的影响密切相关;CYP-35家族在线虫中对3-BrPA代谢中起着关键作用。 | Qiao-ling GU Yan ZHANG Xi-mei FU Zhao-lian LU Yao YU Gen CHEN Rong MA Wei KOU Yong-mei LAN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，1： | 1 |
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