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| 1 | A body mass index ≥25 kg/m2 is associated with a poor prognosis in patients with acute pancreatitis: a study of Japanese patients显示文摘BACKGROUND:In Asian population, there is limited infor mation on the relevance between obesity and poor outcomes in acute pancreatitis(AP). The objective of this study was to examine the clinical impact of obesity based on body mass index(BMI) on prognosis of AP in Japanese patients.METHODS:A total of 116 patients with AP were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to examine relations between BMI and patients' outcomes. Additionally, to investigate whether including obesity as a prognostic factor improved the predic tive accuracy of a Japanese prognostic factor score(PF score)a receiver-operating characteristic(ROC) curve analysis of mortality was conducted.RESULTS:Multiple logistic regression analyses revealed that BMI ≥25 kg/m^2 was associated with a significant higher mor tality [odds ratio(OR)=15.8; 95% confidence interval(CI):1.1-227; P=0.043]. The area under the ROC curve(AUC) for the combination of PF score and BMI ≥25 kg/m^2(AUC=0.881;95% CI:0.809-0.952) was higher than that for the PF score alone(AUC=0.820; 95% CI:0.713-0.927)(P=0.034).CONCLUSIONS:The negative impact of a high BMI on the prognosis of AP was confirmed in a Japanese population Including BMI ≥25 kg/m2 as an additional parameter to PF score enhanced the predictive value of the PF score for AP-related mortality. | Tsukasa Ikeura Kota Kato Makoto Takaoka Masaaki Shimatani Masanobu Kishimoto Kenichiro Nishi Shuji Kariya Kazuichi Okazaki | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，6： | 8 |
| 2 | Microtexture and Distribution of Minerals in Hydrothermal Barite-Silica Chimney from the Franklin Seamount, SW Pacific: Constraints on Mode of Formation显示文摘An extinct hydrothermal barite-silica chimney from the Franklin Seamount of the Woodlark Basin, in the southwestern Pacific Ocean, was investigated for mineral distribution and geochemical composition. Six layers on either side of the orifice of a chimney show significant disparity in color, mineral assemblage and major element composition. Electron microscope(SEM) images reveal that the peripheral wall of the chimney is composed of colloform silica, suggesting that incipient precipitation of silica-saturated hydrothermal fluid initiated the development of the chimney wall. Intermediate layers, between the exterior wall and the inner fluid-orifice, dominate with barite and sulfides. Low Sr-to-Ba ratios(SrO/BaO = 0.015–0.017) indicate restricted fluid-seawater mixing, which causes relatively high-temperature formation of the intermediate layers. Whereas the innermost layer bordering the chimney orifice is characterized by more silica and a higher Sr-to-Ba ratio(SrO/BaO = 0.023), could have formed due to a paragenetic shift from a high-temperature active phase to a cooler waning stage of formation. A paragenetic shift is also probably responsible for the change in mineral formation mechanism that resulted in the textural variation of barite and colloform silica developed during different growth phases of this barite-silica chimney. | Durbar RAY Dalayya KOTA Pranab DAS L.Surya Prakash V.D.KHEDEKAR Anil L.PAROPKARI Abhay V.MUDHOLKAR | 2014 | Acta Geologica Sinica(English Edition)2014，88，1： | 6 |
| 3 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 4 | Proposal of criteria to select candidates with colorectal liver metastases for hepatic resection:Comparison of our scoring system to the positive number of risk factors显示文摘AIM: To select accurately good candidates of hepatic resection for colorectal liver metastasis. METHODS: Thirteen clinicopathological features, which were recognized only before or during surgery, were selected retrospectively in 81 consecutive patients in one hospital (GroupⅠ). These features were entered into a multivariate analysis to determine independent and significant variables affecting long-term prognosis after hepatectomy. Using selected variables, we created a scoring formula to classify patients with colorectal liver metastases to select good candidates for hepatic resection. The usefulness of the new scoring system was examined in a series of 92 patients from another hospital (Group Ⅱ), comparing the number of selected variables. RESULTS: Among 81 patients of GroupⅠ, multivariate analysis, i.e. Cox regression analysis, showed that multiple tumors, the largest tumor greater than 5 cm in diameter, and resectable extrahepatic metastases were significant and independent prognostic factors for poor survival after hepatectomy (P < 0.05). In addition, these three factors: serosa invasion, local lymph node metastases of primary cancers, and post- operative disease free interval less than 1 year including synchronous hepatic metastasis, were not significant, however, they were selected by a stepwise method of Cox regression analysis (0.05 < P < 0.20). Using these six variables, we created a new scoring formula to classify patients with colorectal liver metastases. Finally, our new scoring system not only classified patients in GroupⅠvery well, but also that in Group Ⅱ, according to long-term outcomes after hepatic resection. The positive number of these six variables also classified them well.CONCLUSION: Both, our new scoring system and the positive number of significant prognostic factors are useful to classify patients with colorectal liver metastases in the preoperative selection of good candidates for hepatic resection. | Ikuo Nagashima Tadahiro Takada Miki Adachi Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 5 | Granulomatous reaction in hepatic inflammatory angiomyolipoma after chemoembolization and spontaneous rupture显示文摘A 77-year-old Japanese woman was transported to a nearby hospital due to sudden abdominal pain and transient loss of consciousness. Abdominal computed tomography(CT) suggested hemoperitoneum and hepatic nodule. She was conservatively treated. Contrast-enhanced CT two months later revealed an increased mass size, and the enhancement pattern suggested the possibility of hepatocellular carcinoma(HCC). Under a clinical diagnosis of HCC, transcatheter arterial chemoembolization(TACE) was performed. A subsequent imaging study revealed that most of the lipiodol used for the embolization was washed out. Therefore, surgical resection was performed. Histologically, the nodule contained numerous inflammatory cells including small lymphocytes, plasma cells and macrophages. Notably, epithelioid granulomatous features with multinucleated giant cells were observed in both the nodule and background liver. Some of the multinucleated giant cells contained oil lipid. Among the infiltrating inflammatory cells,spindle-shaped, histiocytoid or myoid tumor cells with eosinophilic cytoplasm were found. The tumor cells were positive for Melan A and HMB45. The nodule contained many Ig G4-positive plasma cells; these were counted and found to number 72.6 cells/HPF(range: 61-80). The calculated Ig G4:Ig G ratio was 33.2%. The nodule was finally diagnosed as previously ruptured inflammatory angiomyolipoma modified by granulomatous reaction after TACE. | Keita Kai Atsushi Miyosh Shinichi Aishima Kota Wakiyama Shunya Nakashita Shinji Iwane Shinya Azama Hiroyuki Irie Hirokazu Noshiro | 2015 | World Journal of Gastroenterology2015，21，32： | 4 |
| 6 | Evaluation of cytotoxic and anti-tumor activity of partially purified serine protease isolate from the Indian earthworm Pheretima posthuma显示文摘Objective:To isolate,partially purify and evaluate the cytotoxic and antitumor activity of a serine protease from the chosen Indian earthworm Pheretima posthuma.Methods:Whole animal extract was prepared and purified its protein constituents by size and charge based chromatographic separation techniques using Sephadex G-50 and DEAE-Cellulose resin respectively.Average molecular weight of the protein isolate was determined and analyzed for its cytotoxic property against Vero cells in different dilutions(1:20 and 1:40)and anti-tumor activity by MTT assay(a colorimetric assay)using breast cancer cell line MCF-7,with tamoxifen as standard.Results:One of the protein constituents after purification was characterized as serine protease by Caseinolytic plate diffusion assay.Average molecular weight of this purified isolate was determined,by SDS-PAGE analysis with standard protein ladder,as of 15 kDa.The performed tests suggested that the 15kDa fraction has potent cytotoxic activity and satisfactory antitumor activity as well in vitro.Conclusions:Exact molecular mechanism of the cytotoxic and antitumor activities is yet to be explored and currently we are working on ultra-purification and biophysical characterization of this fraction.Further investigation into the mechanism(s)of cytotoxic and antitumor activities at molecular level would be useful in treatment of various classes of cancer and viral infections in future. | Mahendra Kumar Verma Francies Xavier Yogendra Kumar Verma Kota Sobha | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，11： | 3 |
| 7 | Oncological results, functional outcomes and health-related quality-of-life in men who received a radical prostatectomy or external beam radiation therapy for localized prostate cancer: a study on long-term patient outcome with risk stratification显示文摘在激进的前列腺切除术(RP ) 或外部横梁放射治疗(EBRT ) 以后的健康相关的 quality-of-life (HRQOL ) 没在与疾病风险层化的关系与 oncological 结果一起被学习。而且,这些治疗途径的长期的结果没被学习。我们回顾地分析了在收到 RP 的连续病人之间的 oncological 结果(n = 86 ) 并且 EBRT (n = 76 ) 为局部性的前列腺癌症。HRQOL 和功能的结果能在 62 RP (79%) 和 54 EBRT (79%) 被估计在一个 3 年的后续时期上的病人(中部:41 个月) 用医药结果学习,短 Form-36 (SF-36 ) 和加利福尼亚大学洛杉机前列腺癌症索引(UCLA 一种总线标准) 。5 年的生物化学的没有前进的幸存没在 RP 和 EBRT 组之间不同为低风险(74.6% 对 75.0% , P = 0.931 ) 并且中间风险(61.3% 对 71.1% , P = 0.691 ) 病人。为高风险的病人,没有前进的幸存比在 EBRT 组(79.7%) 在 RP 组(45.1%) 是更低的(P = 0.002 ) 。一般 HRQOL 在二个组之间是可比较的。关于功能的结果, RP 组比 EBRT 组在尿功能和不太尿的麻烦和性麻烦上报导了更低的分数(P < 0.001, P < 0.05 并且 P < 0.001,分别地) 。与风险层化,在 RP 组的低风险、中间风险的病人在 EBRT 组比病人报导了更差的尿功能(P < 0.001 为各个) 。在 EBRT 组的高风险的病人的性功能比一样的风险 RP 病人的好(P < 0.001 ) 。生物化学的复发没在任何一个组与 UCLA 一种总线标准分数被联系。在结论,低 -- 可以在长期的后续期间向与 RP 对待的中间风险的病人汇报相对减少的尿功能。病人在治疗以后的 HRQOL 没取决于生物化学的复发。 | Itsuhiro Takizawa Noboru Hara Tsutomu Nishiyama Masaaki Kaneko Tatsuhiko Hoshii Emiko Tsuchida Kota Takahashi | 2009 | Asian Journal of Andrology2009，11，3： | 3 |
| 8 | 葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有显示文摘哺乳动物睾丸中的精子经过“附睾成熟”期,由静止状态转变成为运动状态。该过程中精子从附睾头部向附睾尾部移动,同时精子发生了一系列的形态、生理和生化改变,如蛋白组成和蛋白修饰的改变可能会影响精子获能的潜能。本实验使用基质辅助激光解吸/电离串联质谱(MALDI-MS/MS)法分析仓鼠睾丸头部和尾部精子的蛋白组学,成功发现了113个蛋白质点。对113个蛋白质点进一步对照比较发现30个蛋白质点(对应20个蛋白)的密度发生了显著改变,其中附睾尾部精子5个蛋白的密度增加,11个蛋白密度减少;此外,葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有,而纤维蛋白原样蛋白1为附睾尾部精子所特有。几个蛋白密度增加可能与附睾成熟过程中精子代谢和ATP产生相关。一些蛋白如ERp57,GRP78,GP96,Hsp60,Hsp70和二氢硫辛酰胺S-乙酰转移酶的密度改变通过免疫印迹法得到验证。本研究首次报道了仓鼠精子的蛋白质组学研究,全面展示了仓鼠精子附睾成熟过程中的蛋白结构改变。 | Duvvuri Butchi Kameshwari Satish Bhande Curam Sreenivasacharlu Sundaram Venkatesh Kota Archana B. Siva Sisinthy Shivaji | 2010 | Asian Journal of Andrology2010，12，3： | 3 |
| 9 | Bronchial bleeding caused by recurrent pneumonia after radical esophagectomy for esophageal cancer显示文摘We herein report a case of bronchial bleeding afterradical esophagectomy that was treated with lobectomy.A 65-year-old male who underwent subtotal esophagectomy with three-field lymph node dissection for esophageal carcinoma was referred to our hospital because of sudden hemoptysis.After the esophagectomy,bilateral vocal cord paralysis was observed,and the patient suffered from repeated episodes of aspiration pneumonia.Bronchoscopy revealed hemosputum in the right middle lobe bronchus,and contrast-enhanced computed tomography showed tortuous arteries arising from the right inferior phrenic artery and left subclavian artery toward the right middle lobe bronchus.Although bronchial arterial embolization was performed twice to control the recurrent hemoptysis,the procedures were unsuccessful.Right middle lobectomy was therefore performed via video-assisted thoracic surgery.Engorged bronchial arterys with medial hypertrophy and overgrowth of the small branches were noted near the bronchus in the resected specimen.The patient recovered uneventfully and was discharged on postoperative day 14. | Toshihiro Kitajima Kota Momose Seigi Lee Shusuke Haruta Masaki Ueno Hisashi Shinohara Sakashi Fujimori Takeshi Fujii Ryoji Takei Tadasu Kohno Harushi Udagawa | 2015 | World Journal of Gastroenterology2015，21，11： | 3 |
| 10 | Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects显示文摘AIM: To evaluate effects of dietary supplementation of sulforaphane(SF)-rich broccoli sprout(BS) extract on hepatic abnormalities in Japanese male participants.METHODS: In a randomized,placebo-controlled,double blind trial,male participants with fatty liver received either BS capsules containing glucoraphanin [GR; a precursor of SF(n = 24)] or placebo(n = 28) for 2 mo. Liver function markers,serum levels of aspartate and alanine aminotransferases(AST and ALT,respectively) and γ-glutamyl transpeptidase(γ-GTP) and an oxidative stress marker,urinary levels of 8-hydroxydeoxyguanosine(8-OHd G),were measured and compared in participants before and after the trial period. In an animal model,chronic liver failure was induced in Sprague-Dawley rats by successive intraperitoneal injection with N-nitrosodimethylamine(NDMA) for 4 wk. Concomitantly,rats received AIN-76 diets supplemented with or without BS extract. Thereafter,rats were sacrificed,and their sera and livers were collected to measure serum liver function markers and hepatic levels of thiobarbituric acid reactive substances(TBARS) levels and hepatic glutathione S-transferase(GST) activity,a prototypical phase 2 antioxidant enzyme.RESULTS: Dietary supplementation with BS extract containing SF precursor GR for 2 mo significantly decreased serum levels of liver function markers,ALT [median(interquartile range),before: 54.0(34.5-79.0) vs after supplementation: 48.5(33.3-65.3) IU/L,P < 0.05] and γ-GTP [before: 51.5(40.8-91.3) vs after: 50.0(37.8-85.3) IU/L,P < 0.05],as well as the alkali phosphatase activity. Placebo showed no significant effects on the markers. The urinary level of 8-OHd G,an established oxidative stress marker,was significantly reduced in participants who had received BS capsules but not the placebo [before: 6.66(5.51-9.03) vs after: 5.49(4.89-6.66) ng/mg-creatinine,P < 0.05]. The reduction of urinary 8-OHd G was significantly correlated with decreased levels of both ALT and γ-GTP [?8-OHd G and ?ALT: Spearman r(r) 0.514 and P = 0.012,?8-OHd G and ?γ-GTP: r = 0.496 and P = 0.016]. Intake of BS extract prevented NDMA-induced chronic liver failure in rats,which was attributable to the suppression of the increase in TBARS through induction of hepatic phase 2 antioxidant enzymes including hepatic GST(86.6 ± 95.2 vs 107.8 ± 7.7 IU/g,P < 0.01).CONCLUSION: Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress. | Masahiro Kikuchi Yusuke Ushida Hirokazu Shiozawa Rumiko Umeda Kota Tsuruya Yudai Aoki Hiroyuki Suganuma Yasuhiro Nishizaki | 2015 | World Journal of Gastroenterology2015，21，43： | 3 |
| 11 | Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule显示文摘Malignant peritoneal mesothelioma is a rare aggres-sive tumor of the peritoneum. An increasing number of malignant mesothelioma cases have been reported in recent years. We report here a very rare case of malignant peritoneal mesothelioma with both umbilical hernia and umbilical metastasis which is also called Sister Mary Joseph's nodule. We performed laparoscopy which showed specific laparoscopic findings, and the pathological findings of the biopsy specimen led to the diagnosis. This case was associated with umbilical her-nia which could be induced by massive ascites. A newly developed abdominal hernia should be noted as a primary symptom of malignant peritoneal mesothelioma, as shown in the present case. | Kota Tsuruya Masashi Matsushima Takayuki Nakajima Mia Fujisawa Katsuya Shirakura Muneki Igarashi Jun Koike Takayoshi Suzuki Tetsuya Mine | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 2 |
| 12 | Image-based autonomous navigation of Hayabusa2 using artificial landmarks: The design and brief in-flight results of the first landing on asteroid Ryugu显示文摘Hayabusa2 is an asteroid sample return mission carried out by the Japan Aerospace Exploration Agency.The spacecraft was launched in 2014 and arrived at the target asteroid Ryugu on June 27,2018.During the 1.5-year proximity phase,several critical operations(including two landing/sampling operations)were successfully performed.They were based on autonomous image-based descent and landing techniques.This paper describes an imagebased autonomous navigation scheme of the Hayabusa2 mission using artificial landmarks named target markers(TMs).Its basic algorithm,and the in-flight results of the first touchdown and its rehearsal,are shown. | Naoko Ogawa Fuyuto Terui Yuya Mimasu Kent Yoshikawa Go Ono Seiji Yasuda Kota Matsushima Tetsuya Masuda Hiroki Hihara Junpei Sano Takashi Matsuhisa Satoshi Danno Manabu Yamada Yasuhiro Yokota Yuto Takei Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，2： | 2 |
| 13 | Proposal of a new and simple staging system of colorectal liver metastasis显示文摘AIM: To create a new, simple and useful staging system for colorectal liver metastasis analogous to the Tumor Node Metastasis classification system of International Union Against Cancer. METHODS: A retrospective review was undertaken of 81 consecutive patients who underwent partial hepatec- tomy for colorectal liver metastases (group 1). Clinical and pathological features of both primary and metastatic liver cancers were entered into a multivariate analysis to determine independent variables helpful in accurately predicting long-term prognosis after hepatectomy. Using selected variables, we created a new staging system like TNM classification. The usefulness of the new staging system was examined in a series of 92 patients from an- other hospital (group 2). RESULTS: Multivariate analysis showed that 81 patients in group 1 had significant multiple hepatic tumors with the largest tumor being more than 5 cm in diameter, resectable extrahepatic distant metastases, and inde- pendent prognostic factors for poor survival after hepa- tectomy. Using these three variables, we created a new staging system to classify patients with colorectal liver metastases. Finally, our new staging system classified the patients both in group 1 and in group 2. CONCLUSION: Our new staging system of colorectal liver metastasis is simple and useful for staging patients. | Ikuo Nagashima Tadahiro Takada Hirokazu Nagawa Tetsuichiro Muto Kota Okinaga | 2006 | World Journal of Gastroenterology2006，12，43： | 2 |
| 14 | Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model显示文摘 | Janaiah Kota Raghu R. Chivukula Kathryn A. O’Donnell Erik A. Wentzel Chrystal L. Montgomery Hun-Way Hwang Tsung-Cheng Chang Perumal Vivekanandan Michael Torbenson K. Reed Clark Jerry R. Mendell Joshua T. Mendell | 2009 | Cell2009，，6： | 2 |
| 15 | 卫星移动通信系统的发展现状与比较分析显示文摘卫星系统具有覆盖面宽、广播/多等特性,是人口稀少地区、紧急事件地区,以及飞机、火车、舰船上的重要的通信手段。本文从不同的角度出发,围绕最近的研究议题、最新的标准,探讨了当前的卫星移动网络及业务。最后对不同的卫星移动系统的特性、业务能力、资源使用效率及用户的移动性进行了定量、定性的分析与比较。 | Paolo Chini Giovanni Giambene Sastri Kota 吕京梅 王琦 | 2012 | 卫星与网络2012，，5： | 2 |
| 16 | Implementing a vector surveillanceresponse system for chagas disease control:a 4-year field trial in Nicaragua显示文摘Background:Chagas disease is one of the neglected tropical diseases(NTDs).International goals for its control involve elimination of vector-borne transmission.Central American countries face challenges in establishing sustainable vector control programmes,since the main vector,Triatoma dimidiata,cannot be eliminated.In 2012,the Ministry of Health in Nicaragua started a field test of a vector surveillance-response system to control domestic vector infestation.This paper reports the main findings from this pilot study.Methods:This study was carried out from 2012 to 2015 in the Municipality of Totogalpa.The Japan International Cooperation Agency provided technical cooperation in designing and monitoring the surveillance-response system until 2014.This system involved 1)vector reports by householders to health facilities,2)data analysis and planning of responses at the municipal health centre and 3)house visits or insecticide spraying by health personnel as a response.We registered all vector reports and responses in a digital database.The collected data were used to describe and analyse the system performance in terms of amount of vector reports as well as rates and timeliness of responses.Results:During the study period,T.dimidiata was reported 396 times.Spatiotemporal analysis identified some high-risk clusters.All houses reported to be infested were visited by health personnel in 2013 and this response rate dropped to 39%in 2015.Rates of insecticide spraying rose above 80%in 2013 but no spraying was carried out in the following 2 years.The timeliness of house visits improved significantly after the responsibility was transferred from a vector control technician to primary health care staff.Conclusions:We argue that the proposed vector surveillance-response system is workable within the resourceconstrained health system in Nicaragua.Integration to the primary health care services was a key to improve the system performance.Continual efforts are necessary to keep adapting the surveillance-response system to the dynamic health systems.We also discuss that the goal of eliminating vector-borne transmission remains unachievable.This paper provides lessons not only for Chagas disease control in Central America,but also for control efforts for other NTDs that need a sustainable surveillance-response system to support elimination. | Kota Yoshioka Doribel Tercero Byron Perez Jiro Nakamura Lenin Perez | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 17 | Achieving the Goals of Healthy China 2030 Depends on Increasing Smoking Cessation in China:Comparative Findings from the ITC Project in China,Japan,and the Republic of Korea显示文摘Summary Tobacco smoking is the number one preventable cause of disease and death in China as it is globally.Indeed,the toll of smoking in China is much greater than its status as the world’s most populous country.There is a persistent and continuing need for China to implement the measures specified in the global tobacco control treaty,the World Health Organization(WHO)Framework Convention on Tobacco Control(FCTC),which China ratified in 2005. | Geoffrey T.Fong Jiang Yuan Lorraine V.Craig Steve Shaowei Xu Gang Meng Anne C.K.Quah Hong-Gwan Seo Sungkyu Lee Itsuro Yoshimi Kota Katanoda Takahiro Tabuchi | 2021 | China CDC weekly2021，3，22： | 2 |
| 18 | Conceptual design of mechanisms based on computational synthesis and simulation of kinetic building blocks显示文摘 | Kota | 1992 | Research in engineering design1992，4，1： | 2 |
| 19 | Prediction of wall deposition behaviour in a pilot-scale spray dryer using deposition correlations for pipe flows显示文摘The particle deposition behaviour of skim milk, water and maltodextrin in the conical section of a pilot-scale spray dryer was predicted using simple correlations for particle depositions in pipes. The predicted particle deposition fluxes of these materials were then compared with the measured deposition fluxes. The predicted particle deposition regimes of the spray dryer were expected to be in the diffusional and mixed (diffusional and inertial) regimes, but the experimental results suggested that the particle deposition was mainly in the inertial regime. Therefore, using the pipe correlations for predicting deposition in a pilot-scale spray dryer suggests that they do not sufficiently represent the actual deposition behaviour. This outcome indicates that a further study of particle flow patterns needs to be carried out using numerical simulations (computational fluid dynamics, CFD) in view of the additional geometrical complexity of the spray dryer. | KOTA K. LANGRISH T.A.G. | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，2： | 2 |
| 20 | Prediction of return of spontaneous circulation in outof-hospital cardiac arrest with non-shockable initial rhythm using point-of-care testing: a retrospective observational study显示文摘BACKGROUND:Out-of-hospital cardiac arrest(OHCA) is a public health concern, and many studies have been conducted on return of spontaneous circulation(ROSC) and its prognostic factors.Rotational thromboelastometry(ROTEM?), a point-of-care testing(POCT) method, has been useful for predicting ROSC in patients with OHCA, but very few studies have focused on patients with non-shockable rhythm. We examined whether the parameters of POCT could predict ROSC in patients with OHCA and accompanying non-shockable rhythm.METHODS:This is a single-center, retrospective observational study. Complete blood count,blood gas, and ROTEM POCT measurements were used. This study included patients with nontraumatic OHCA aged 18 years or older who were transported to the emergency department and evaluated using POCT between January 2013 and December 2021. The patients were divided into the ROSC and non-ROSC groups. Prehospital information and POCT parameters were compared using receiver operating characteristic(ROC) curve analysis, and further logistic regression analysis was performed.RESULTS:Sixty-seven and 135 patients were in the ROSC and non-ROSC groups,respectively. The ROC curves showed a high area under the curve(AUC) for K^(+) of 0.77(95%confidence interval [CI]:0.71–0.83) and EXTEM amplitude 5 min after clotting time(A5) of 0.70(95%CI:0.62–0.77). The odds ratios for ROSC were as follows:female sex 3.67(95%CI:1.67–8.04);K^(+)0.64(95%CI:0.48–0.84);and EXTEM A5 1.03(95%CI:1.01–1.06).CONCLUSION:In OHCA patients with non-shockable rhythm, K^(+) level and the ROTEM parameter EXTEM A5 may be useful in predicting ROSC. | Kota Shinada Hiroyuki Koami Ayaka Matsuoka Yuichiro Sakamoto | 2023 | World Journal of Emergency Medicine2023，14，2： | 2 |
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