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| 1 | Capsule endoscopy: Improving transit time and image view显示文摘AIM: To evaluate the effect of various methods of small bowel preparation on the transit time and the quality of visualization of the entire small bowel mucosa.METHODS: Ninety-five patients underwent capsule endoscopy (CE) by easily swallowing the capsule. They were divided into three study groups according to the preparation used: group A (n = 26) by polyethylene glycol (PEG) liter or with sodium phosphate (SP) 12 h prior to the CE study; group B (n = 29) by erythromycin 1 h prior to the CE study; and group C (n = 40) without any preparation. Visualization ranged from good to satisfactory to poor.RESULTS: The gastric emptying time in the group prepared with erythromycin was shorter but without statistical significance and the small bowel transit time was unaffected. In elderly subjects prepared by PEG or SP, the gastric emptying time was significantly longer (163.7 min, P = 0.05). The transit times of the three sub-groups were not affected by gender or pathology.The grade of cleaning of the entire study group was 3.27±1.1. The erythromycin group presented significantly the worst quality of images (P = 0.05) compared to the other sub-groups. Age, gender, and pathology had no effect on the quality of the cleaning of the small bowel in the sub-groups. One (1.05%) case had no natural excretion.CONCLUSION: Erythromycin markedly reduces gastric emptying time, but has a negative effect on the quality of the image in the small bowel. The preparation of elderly subjects with PEG or SP has a negative effect on the small bowel transit time. | Zvi Fireman D Paz Y Kopelman | 2005 | World Journal of Gastroenterology2005，11，37： | 25 |
| 2 | Effect of erythromycin on image quality and transit time of capsule endoscopy: A two-center study显示文摘AIM: To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology. METHODS: We conducted a retrospective, blinded (to the type of preparation) review of 100 CE studies, 50 with no preparation with prokinetics from one medical center (Group A) and 50 from another center with administration of a single dose of 200 mg oral erythromycin 1 h prior to CE (Group B). Gastric, SB and total transit times were calculated, the presence of bile in the duodenum was scored, as was cleanliness within the proximal, middle and distal intestine. RESULTS: The erythromycin group had a slightly shorter gastric transit time (21 min vs 28 min, with no statistical significance). SB transit time was similar for both groups (all P > 0.05). Total transit time was almost identical in both groups. The rate of incomplete examination was 16% for Group A and 10% for Group B (P = 0.37). Bile and cleanliness scores in different parts of the intestine were similar for the two groups (P > 0.05). CONCLUSION: Preparation for capsule endoscopy with erythromycin does not affect SB or total transit time. It tends to reduce gastric transit time, but it does not increase the cecum-reaching rate. Erythromycin does not adversely affect image quality. We consider the routine use of oral erythromycin preparation as being unjustified, although it might be considered in patients with known prolonged gastric emptying time. | Eva Niv Ido Bogner Olga Barkey Zamir Halpern Elisabeth Mahajna Roman Depsames Yael Kopelman Zvi Fireman | 2008 | World Journal of Gastroenterology2008，14，16： | 10 |
| 3 | Targeted Blue Nanoparticles as Photoacoustic Contrast Agent for Brain Tumor Delineation显示文摘把一个肿瘤与非肿瘤的组织区分开来在癌症外科期间是一项挑战性的任务。几次尝试被做了使用可见或荧光灯的代理人在外科期间帮助一个肿瘤的可视化。我们描述一个新奇方法描出大脑肿瘤,用一种高度敏感的 photoacoustic 成像技术,那被用作一个对比代理人的指向肿瘤的蓝 nanoparticles 提高。幽灵并且在老鼠大脑上的实验,前 vivo,在描出表明 photoacoustic 成像的高敏感在集中包含对比代理人的肿瘤很比由肉眼为可视化需要降低。为 nanoparticles 的系统的察觉的限制是水(到 0.84 mol/L Coomassie 蓝染料的等价物) 里的大约 0.77 g/mL。当与强烈光的吸收对比代理人使用了时,现在的探索学习建议那 photoacoustic 成像,能由揭示肿瘤的分发和程度 intraoperatively 便于癌症外科。 | Aniruddha Ray Xueding Wang Yong-Eun Koo Lee Hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman | 2011 | Nano Research2011，4，11： | 5 |
| 4 | MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer显示文摘 | Schachaf CM Kopelman AM Arvanitis C | 2004 | Nature2004，431，5： | 1 |
| 5 | Capto- pril-induced functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery steno- sis in a solitary kidney显示文摘 | Hricik D E Browning P J Kopelman R | 1983 | N Engl J Med1983，308，7： | 1 |
| 6 | Age and indication for referral to capsule endoscopy significantly affect small bowel transit times : the given database 显示文摘 | Fireman Z Kopelman Y Friedman S | 2007 | Dig Dis Sci2007，52，10： | 1 |
| 7 | Pancreatic duct injury:intraoperative endoscopic transpancreatic drainage of parapancreatic abscess 显示文摘 | Suissa A Klein Y | 1998 | J Trauma1998，44，： | 1 |
| 8 | Physiopathology of prolactin secretion in obesity 显示文摘 | | 2000 | Int J Obes Relat Metab Disord2000，24，： | 1 |
| 9 | Make her a virgin again: when medical disputes a- bout minors are cultural clashes显示文摘 | Kopelman LM | 2014 | J Med Philos2014，39，1： | 1 |
| 10 | Advanced brain imaging procedures and human memory disorder显示文摘 | Narinder Kapur Michael D Kopelman | 2003 | British Medical Bulletin2003，，： | 1 |
| 11 | Abdominal compartment syndrome in patients with isolated extraperitoneal injuries 显示文摘 | Kopelman T Harris C Miller R | 2000 | J Trauma2000，49，4： | 1 |
| 12 | An anomaly of the extrahepatic biliary system显示文摘 | Hashmonai M Kopelman D | 1995 | Arch Surg1995，130，6： | 1 |
| 13 | Obesity as a medical problem显示文摘 | KOPELMAN P G | 2000 | Nature2000，404，： | 1 |
| 14 | MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer显示文摘 | SHACHAF C M KOPELMAN A M ARVANITIS C | 2004 | Nature2004，431，7012： | 1 |
| 15 | Minimal Risk as an international ethical standard in Research 显示文摘 | Kopelman LM | 2004 | Journal of Med- icine and Philosophy2004，29，3： | 1 |
| 16 | The embedding of meta-tetra (hydroxyphenyl)-chlorin into silica nanoparticle platforms for photodynamic therapy and their singlet oxygen production and pH-dependent optical properties显示文摘 | Yan F Kopelman R | 2003 | Photochemistry and Photobiology2003，78，6： | 1 |
| 17 | A real - time ratiometric method for the determination of molecular oxygen inside living cells using sol- gel- based spherical optical nanosensors with applications to rat C6 glioma显示文摘 | Xu H Aylott J W Kopelman R etal | 2001 | Philbert Anal Chem2001，73，17： | 1 |
| 18 | MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular carcinoma显示文摘 | Shachaf CM Kopelman AM Arvanitis C | 2004 | Nature2004，431，： | 1 |
| 19 | Photodynamic characterization and in vitro application of methylene blue-containing nanoparticle platforms显示文摘 | Tang W Xu H Kopelman R | 2005 | Photochemistry and Photobiology2005，81，2： | 1 |
| 20 | A Mutant Drosophila Insulin Receptor Homolog That Extends Life - Span and Impairs Neurcendocrine Function 显示文摘 | Tatar M Kopelman A Epstein D | 2001 | Science2001，292，6： | 1 |
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