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| 1 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 2 | Complications of sevoflurane-fentanyl versus midazolam-fentanyl anesthesia in pediatric cleft lip and palate surgery:a randomized comparison study显示文摘 | Miliec M Goranovic T Knezevic P | 2010 | Int J Oral Maxillofac Surg2010，39，1： | 1 |
| 3 | SPONGENT: The design space of lightweight cryptographie hashing显示文摘 | Bogdanov A Knezevic M Leander G | 2013 | IEEE Transactions on computers2013，62，10： | 1 |
| 4 | Application- oriented comparison of the methods for AC/DC converter harmonics analysis显示文摘 | Katic V A Knezevic J M Graovac D | 2003 | IEEE Transactions on Industrial Electronics2003，50，6： | 1 |
| 5 | Gas-agitated liquid-liquid extraction in a spray column显示文摘 | Sovilj M Knezevic G | 1994 | CollectCzech Chem Commun1994，59，10： | 1 |
| 6 | Laparoscopic adrenalectomy:lessons learned from 306 cases显示文摘 | Kulis T Knezevic N Pekez M | 2012 | J Laparoendosc Adv Surg Tech2012，22，1： | 1 |
| 7 | Hydrothermal conversion of biomass: I , glucose conversion in hot compressed water 显示文摘 | Knezevic D Van Swaaij W P M Kersten S R A | 2009 | Industry & Engineering Chemistry Research2009，48，10： | 1 |
| 8 | Immunogenicity assessment of biotherapeutlc products: an overview of assays and their utility 显示文摘 | WADHWA M KNEZEVIC I KANG HN | 2015 | Biologicals2015，43，5： | 1 |
| 9 | Autotransplantation of the spleen 显示文摘 | Knezevic S Stefanovic D Petrovie M | 2003 | Acta Chit Iugosl2003，49，3： | 1 |
| 10 | Protein allelic composition, dough rheology and baking characteristics of flour streams from wheat cultivars with known and varied baking qualities 显示文摘 | Menkovska M Knezevic D Ivanoski M | 2002 | Cereal Chemistry2002，79，5： | 1 |
| 11 | Antioxidant protective effects of mushroom metabolites 显示文摘 | Stajic M Vukojevic J Knezevic A | 2013 | Current Topics in Medicinal Chemistry2013，13，21： | 1 |
| 12 | Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells 显示文摘 | Tauseef M Kini V Knezevic N | 2008 | Circ Res2008，103，10： | 1 |
| 13 | Antioxidant protective effects of mushroom metabolites 显示文摘 | Stajic M Vukojevic J Knezevic A | 2013 | Current Topics in Medicinal Chemistry2013，13，21： | 1 |
| 14 | Optimization of the tractive performance of four - wheel - drive tractors: theoretical analysis and experimental substantiation显示文摘 | Wong J Y Mclaughlin N M Knezevic Z | 1998 | Journal of Automobile Engineering1998，221，4： | 1 |
| 15 | Association of red blood cell transfusion, anemia, and necrotizing en- terocolitis in very low-birth-weight infants 显示文摘 | Patel R M Knezevic A Shenvi N | 2016 | JAMA2016，315，9： | 1 |
| 16 | WHO Working Group meeting on standardization of acellular pertussis vaccines: Potency assay Beijing, China, 7-9 November 2007 显示文摘 | Knezevic I Baca-Estrada M Xing DK | 2008 | Vaccine2008，26，32： | 1 |
| 17 | WHO Working Group on the standardisation and control of pertussis vaccines-report of a meeting held on 6-7 May 2003,Ferney Voltaire,France显示文摘 | Corbel M J Kreeftenberg JG Knezevic I | 2004 | Vaccine2004，22，34： | 1 |
| 18 | Retinoic acid induces pdxl-positive endoderm in differentiating mouse embryonic stein cells 显示文摘 | MICALLEF S JANES M E KNEZEVIC K | 2005 | Diabetes2005，54，2： | 1 |
| 19 | Fluid-bed microencapsulation of ascorbic acid 显示文摘 | Knezevic Z Gosak D Hraster M | 1998 | J Microencapsul1998，15，2： | 1 |
| 20 | Phagocytic functions of salivary neutrophils in oral mucous membrane diseases显示文摘 | Lukac J Mravak-Stipetic M Knezevic M | 2003 | J Oral Pathol Med2003，32，5： | 1 |
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