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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 4 | Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: a phase II study显示文摘 | Olivier Rixe Ronald M Bukowski M Dror Michaelson George Wilding Gary R Hudes Oliver Bolte Robert J Motzer Paul Bycott Katherine F Liau James Freddo Peter C Trask Sinil Kim Brian I Rini | 2007 | Lancet Oncology2007，，： | 2 |
| 5 | Direct polymerization of sulfonated poly(arylene ether sulfone) random (statistical) copolymers:candidates for new proton exchange membranes显示文摘 | WANG F HICKER M KIM Y S | 2002 | J Membr Sci2002，197，： | 1 |
| 6 | Determination methods of Rehmanniae Radix by HPLC 显示文摘 | Zhu M F Hong Seon-Pyo Kim Chungsook | 2003 | Korea J Herbology2003，18，3： | 1 |
| 7 | Stretchable microfluidic radiofreqnency antennas显示文摘 | KUBO M LI X F KIM C | 2010 | Advanced Materials2010，22，25： | 1 |
| 8 | Spontaneous forma-tion of bonelike apatite layer on chemically treated titanium metals显示文摘 | Kokubo T Miyaii F Kim H M | 1996 | J Am Ceram Soc1996，79，4： | 1 |
| 9 | Traumatic aortic rupture,30 years of experience显示文摘 | Cindy M Sabrina H Kim D Geert M Inge F | | 0，，： | 1 |
| 10 | Cetylpyridinium chloride ( CPC ) treatment on poultry skin to reduce attached Salmonella 显示文摘 | Kim J W Slavik M F | 1996 | Journal of Food Protection1996，59，3： | 1 |
| 11 | Pilot randomized clinical trial of prehospital induction of mild hypothermia in out-of-hospital cardiac arrest patients with a rapid infusion of 4 degrees C normal saline 显示文摘 | Kim F Olsufka M Longstreth WT | 2007 | Circulation2007，115，24： | 1 |
| 12 | Immunogenicity of an adenoviral- based middle east respiratory syndrome coronavirus vaccine in balb/c mice显示文摘 | Kim E Okada K Kenniston T Raj V S A1Hajri M M Farag E A AIHairi F Osterhaus A D Haagmans B L Gambotto A | 2014 | Vaccine2014，32，45： | 1 |
| 13 | Characteristics of protease from shrimp processing discards 显示文摘 | Heu M S Kim J S Shahidi F | 2003 | Journal of Food Biochemistry2003，27，： | 1 |
| 14 | Slinding wear behavior of TiN and CrN coated 2024 aluminum alloy against an A1203 ball显示文摘 | ZHOU F SUH C M KIM S S | 2002 | Tribology Letters2002，13，3： | 1 |
| 15 | Ductility and Cracking Behavior of Prestressed Concrete Beams Strengthened with Prestressed CFRP Sheets 显示文摘 | KIM Y J SHI C GREEN M F | 2008 | Journal of Composites for Construction2008，12，3： | 1 |
| 16 | A Modified Cellular Automaton Model for the Simulation of Dendritic Growth in Solidification of Alloy 显示文摘 | M F Zhu J M Kim C P Hong | 2001 | ISIJ2001，41，： | 1 |
| 17 | Fabrication and characterization of heteropolyacid(H3PW12O40)/directly polymerized sulfonated poly (arylene ether sulfone) copolymer composite membranes for higher temperature fuel cell applications 显示文摘 | KIM Y S WANG F HICKER M | 2003 | J Membr Sci2003，212，： | 1 |
| 18 | A stable Ti-based quasicrystal显示文摘 | Kehon K F Kim W J Stroud R M | 1997 | Appl Phys Lett1997，70，： | 1 |
| 19 | Influence of ultrasonication on the mechanical properties of Cu/AI203 nanocomposite thin fihns during electrocodeposition 显示文摘 | KIM M SUN F 17 LEE J HYUN Y K LEE D Y | 2010 | Surface & Coatings Technology2010，205，7： | 1 |
| 20 | Effect of heat treatment on apatite forming ability of Ti metal induced by alkali treatment显示文摘 | Kim H M Miyaji F Kokubo T | 1997 | J Mater Sci: Mater Med1997，8，： | 1 |
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