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| 1 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 2 | Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture显示文摘AIM:To investigate the usefulness of chromoendoscopy,using an acetic acid indigocarmine mixture(AIM),for gastric adenoma diagnosed by forceps biopsy.METHODS:A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection(ESD)between January 2011 and January 2012.AIM-chromoendoscopy(AIMCE)was performed followed by ESD.AIM solution was sprinkled and images were recorded every 30 s for 3min.Clinical characteristics such as tumor size(<2cm,≥2 cm),surface color in white light endoscopy(WLE)(whitish,normochromic or reddish),macroscopic appearance(flat or elevated,depressed),and reddish change in AIM-CE were selected as valuables.RESULTS:En bloc resection was achieved in all 54 cases,with curative resection of fifty two lesions(96.3%).Twenty three lesions(42.6%)were diagnosed as welldifferentiated adenocarcinoma and the remaining 31lesions(57.4%)were gastric adenoma.All adenocarcinoma lesions were well-differentiated tubular adenocarcinomas and were restricted within the mucosal layer.The sensitivity of reddish color change in AIM-CE is significantly higher than that in WLE(vs tumor size≥2 cm,P=0.016,vs normochromic or reddish surface color,P=0.046,vs depressed macroscopic type,P=0.0030).On the other hand,no significant differences were found in the specificity and accuracy.In univariate analysis,normochromic or reddish surface color in WLE(OR=3.7,95%CI:1.2-12,P=0.022)and reddish change in AIM-CE(OR=14,95%CI:3.8-70,P<0.001)were significantly related to diagnosis of early gastric cancer(EGC).In multivariate analysis,only reddish change in AIM-CE(OR=11,95%CI:2.3-66,P=0.0022)was a significant factor associated with diagnosis of EGC.CONCLUSION:AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy. | Yoshiyasu Kono Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Seiji Kawano Yasushi Yamasaki Koji Takemoto Takayoshi Miyake Shigeatsu Fujiki Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，17： | 12 |
| 3 | Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement显示文摘AIM: To evaluate the endoscopic manifestations and prognoses of gastrointestinal (GI) mantle cell lymphoma (MCL). METHODS: A database search at the Department of Pathology of Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences revealed 57 MCL patients with GI involvement. Clinical records were available for 35 of the 57 patients from 21 institutions, and those 35 patients were enrolled in this study. We summarized the gross types of endoscopic features, event-free survival (EFS), and overall survival (OS) of those patients.RESULTS: Of the 35 patients, GI involvement in the esophagus, stomach, and duodenum was found in 2 (5.7%), 26 (74.3%), and 12 (34.3%) patients, respectively. Twenty-one of the 35 patients underwent colonoscopy; among them, GI involvement in the ileum, cecum, colon, and rectum was found in 10 (47.6%), 3 (14.3%), 12 (57.1%), and 10 (47.6%), respectively. Various lesions, such as superficial, protruded, fold thickening, or ulcerative, were found in the stomach, whereas multiple lymphomatous polyposis (MLP) was dominant from the duodenum to the rectum. Twelve patients were treated with a hyper-CVAD/MA regimen, and they had better OS (3-year rate, 88.3% vs 46.4%, P < 0.01) and better EFS (3-year rate, 66.7% vs 33.8%, P < 0.05) than the remaining 23 patients who were not treated with this regimen. CONCLUSION: MLP was a representative form of intestinal involvement, whereas a variety of lesions were found in the stomach. The hyper-CVAD/MA regimen may improve survival in these patients. | Masaya Iwamuro Hiroyuki Okada Yoshiro Kawahara Katsuji Shinagawa Toshiaki Morito Tadashi Yoshino Kazuhide Yamamoto | 2010 | World Journal of Gastroenterology2010，16，37： | 9 |
| 4 | Expression of Interleukin-26 is upregulated in inflammatory bowel disease显示文摘AIM To investigate interleukin(IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease(IBD) and the function of IL-26. METHODS Human colonic subepithelial myofibroblasts(SEMFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The gene expression induced by IL-26 was evaluated by realtime polymerase chain reaction. Intracellular signaling pathways were evaluated by immunoblotting and specific small interfering(si) RNA transfection. RESULTS The m RNA and protein expression of IL-26 were significantly enhanced in the inflamed mucosa of patients with IBD. IL-26 receptor complex was expressed in colonic SEMFs in vivo and in vitro. IL-26 stimulated the m RNA expression of IL-6 and IL-8 in colonic SEMFs. The inhibitors of mitogen-activated protein kinases and phosphoinositide 3-kinase, and si RNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the m RNA expression of IL-6 and IL-8 induced by IL-26.CONCLUSION These results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators. | Makoto Fujii Atsushi Nishida Hirotsugu Imaeda Masashi Ohno Kyohei Nishino Shigeki Sakai Osamu Inatomi Shigeki Bamba Masahiro Kawahara Tomoharu Shimizu Akira Andoh | 2017 | World Journal of Gastroenterology2017，23，30： | 8 |
| 5 | 一期后路闭合式-张开式联合楔形截骨术矫正角形脊柱后凸显示文摘[目的]检验闭合式-张开式联合楔形截骨术治疗角形脊柱后凸的有效性和安全性。采用一期后路闭合式-张开式联合楔形截骨术的方法对7名患有胸腰椎角形脊柱后凸畸形的患者进行治疗。[方法]7名角形脊柱后凸患者,其后凸顶点位于T51例,位于T111例,位于T125例。其中5例存在有陈旧性骨折,1例为先天性畸形和1例患有神经纤维瘤病。首先用闭合式楔形截骨术将脊柱后凸矫正30°~35°,在施行椎骨切除术和脊髓减压时其矫正的中心点位于前纵韧带。随后用张开式楔形截骨术对残余的截骨角度予以矫正时,其矫正的中心点位于脊髓和剩余的截骨角之上。脊柱的稳定性则采用后路器械内固定和植骨予以保证。[结果]在2.2~7.5年的随访中,患者局部后凸的角度减少了67°~18°。自T1至骶骨的矢状位排列较术前更加符合生理曲线。所有的患者均获得了良好的骨质愈合并且没有神经性并发症发生,也没有矫正度数的丢失。[结论]在直视下,采用闭合式-张开式联合楔形截骨术的矫正效果和脊髓减压是令人满意和放心的。虽然手术的过程是异常艰巨的,但它却提供了一个没有脊髓损伤的、良好的矫正效果。 | Norio Kawahara 孙改生 田慧中 | 2007 | 中国矫形外科杂志2007，15，17： | 5 |
| 6 | Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening显示文摘AIM:To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy.METHODS:We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer.All patients were divided into two groups:a magnifying narrow band imaging group,and a lugol chromoendoscopy group,for comparison of adverse symptoms.Esophageal cancer screening was performed on withdrawal of the endoscope.The primary endpoint was a score on a visual analogue scale for heartburn after the examination.The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations,change in vital signs,total procedure time,and esophageal observation time.RESULTS:The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group(P =0.004,0.024,respectively,ANOVA for repeated measures).The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group.There was no significant difference between the two groups with respect to othervital sign.The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group(450 ± 116 vs 565 ± 174,P =0.004,44 ± 26 vs 151 ± 72,P < 0.001,respectively).CONCLUSION:Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy.Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically. | Yasushi Yamasaki Ryuta Takenaka Keisuke Hori Koji Takemoto Seiji Kawano Yoshiro Kawahara Hiroyuki Okada Shigeatsu Fujiki Kazuhide Yamamoto | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 7 | Magnifying Narrowband Imaging Is More Accurate Than Conventional White-Light Imaging in Diagnosis of Gastric Mucosal Cancer显示文摘 | Yasumasa Ezoe Manabu Muto Noriya Uedo Hisashi Doyama Kenshi Yao Ichiro Oda Kazuhiro Kaneko Yoshiro Kawahara Chizu Yokoi Yasushi Sugiura Hideki Ishikawa Yoji Takeuchi Yoshibumi Kaneko Yutaka Saito | 2011 | Gastroenterology2011，，6： | 4 |
| 8 | Evaluation of endoscopic biliary stenting for obstructive jaundice caused by hepatocellular carcinoma显示文摘AIM:To review the usefulness of endoscopic biliary stenting for obstructive jaundice caused by hepatocellular carcinoma and identify problems that may need to be addressed.METHODS:The study population consisted of 36 patients with obstructive jaundice caused by hepatocellular carcinoma(HCC)who underwent endoscopic biliary stenting(EBS)as the initial drainage procedure at our hospital.The EBS technical success rate and drainage success rate were assessed.Drainage was considered effective when the serum total bilirubin level decreased by 50%or more following the procedure compared to the pre-drainage value.Survival time after the procedure and patient background characteristics were assessed comparatively between the successful drainage group(group A)and the non-successful drainage group(group B).The EBS stent patency duration in the successful drainage group(group A)was also assessed.RESULTS:The technical success rate was 100%for both the initial endoscopic nasobiliary drainage and EBS in all patients.Single stenting was placed in 21 patients and multiple stenting in the remaining 15 patients.The drainage successful rate was 75%and the median interval to successful drainage was 40 d(2-295 d).The median survival time was 150 d in group A and 22 d in group B,with the difference between the two groups being statistically significant(P<0.0001).There were no statistically significant differences between the two groups with respect to patient background characteristics,background liver condition,or tumor factors;on the other hand,the two groups showed statistically significant differences in patients without a history of hepatectomy(P=0.009)and those that received multiple stenting(P=0.036).The median duration of stent patency was 43 d in group A(2-757 d).No early complications related to the EBS technique were encountered.Late complications occurred in 13 patients(36.1%),including stent occlusion in 7,infection in 3,and distal migration in 3.CONCLUSION:EBS is recommended as the initial drainage procedure for obstructive jaundice caused by HCC,as it appears to contribute to prolongation of survival time. | Gen Sugiyama Yoshinobu Okabe Yusuke Ishida Fumihiko Saitou Ryuichi Kawahara Hiroto Ishikawa Hiroyuki Horiuchi Hisafumi Kinoshita Osamu Tsuruta Michio Sata | 2014 | World Journal of Gastroenterology2014，20，22： | 4 |
| 9 | miR-218 on the genomic loss region of chromosome 4p15.31 functions asa tumor suppressor in bladder cancer显示文摘 | Shuichi Tatarano Takeshi Chiyomaru Kazumori Kawakami Hideki Enokida Hirofumi Yoshino Hideo Hidaka Takeshi Yamasaki Kazuya Kawahara Kenryu Nishiyama Naohiko Seki Masayuki Nakagawa | 2011 | International Journal of Oncology2011，，1： | 3 |
| 10 | Effects of Solid Solution Treating on the Microstructureand Damping Behaviour of MnCuNiFe Alloys显示文摘一个高抑制条件容易在 Mn-(16-24 )Cu-(4-6 ) Ni-2Fe 被获得(在。%) 合金,当冷却时,率在 1173 K 在稳固的答案处理以后被控制。在 10 h 的对数的减少的温度依赖者变化使样品凉下来,这被观察对合金作文敏感。作为与熄灭处理的水相比,控制了 10 h 冷却由在合金生产充实 Mn 的矩阵部分广泛地改进合金的 T//N 温度。计算建议在矩阵部分的 Cu 和 Ni 内容的相对减少被 Ni 内容在原来的合金统治,并且因此, Cu 的体积部分,充实 Ni 猛抛被估计分别地在 4Ni 和 6Ni 合金是大约 20% 和 10% 。作为结果,为每合金的 T//N 温度,相应于对数的减少的升起的温度,在充实 Mn 的矩阵与 Cu,和 Ni 有关。左钩住的存在 110 条正确钩住 twinning 边界在 4Ni 和 6Ni 合金的微观结构被证实。然而,相对格子紧张, twinning 边界扮演提供,在二合金被发现大部分不同。有更小的取向偏差的边界能由周期的移动容易协调外部压力,这被考虑,因此,发生在 10 h 的更宽广的抑制山峰使 6Ni 凉下来合金变得可行。电子衍射结果也在矩阵阶段显示许多亚水晶的可能的形成,它相对在一些不变的飞机上被旋转。那些亚水晶边界可能在在 T//N 和房间温度之间的温度范围起一些变细作用。(编辑作者摘要) 9 个裁判员。 | Yin, Fuxing Ohsawa, Y. Sato, A. Kawahara, K. | 1998 | Journal of Materials Science & Technology1998，14，4： | 3 |
| 11 | Structural transition of silicene on Ag(111)显示文摘 | Ryuichi Arafune Chun-Liang Lin Kazuaki Kawahara Noriyuki Tsukahara Emi Minamitani Yousoo Kim Noriaki Takagi Maki Kawai | 2013 | Surface Science2013，，： | 3 |
| 12 | 高脱蛋白天然橡胶的热学性能和结晶特性显示文摘前言橡胶的密度(ρ),热膨胀系数(α),玻璃化转变温度(Tg)和平衡熔融温度(T°m)是实际设计橡胶零件的重要因素。Wood汇总了未处理硫化天然胶的这些性能变化情况。例如用水和乙醇冲洗过的天然胶的热膨胀系数增大,但密度完全没有改变,另一方面,脱蛋白可使玻璃化转变温度上升,其中用冲洗的方法使氮的含量从0.38%减少到0.14%,相当于0.88%的蛋白质。 | Seiiclli Kawahara 王贵一 | 2000 | 橡胶参考资料2000，30，6： | 3 |
| 13 | C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells显示文摘 | Ko-ichi Kawahara Kamal Krishna Biswas Masako Unoshima Takashi Ito Kiyoshi Kikuchi Yoko Morimoto Masahiro Iwata Salunya Tancharoen Yoko Oyama Kazunori Takenouchi Yuko Nawa Noboru Arimura Meng Xiao Jie Binita Shrestha Naoki Miura Toshiaki Shimizu Kentaro Me | 2008 | Cardiovascular Pathology2008，，3： | 3 |
| 14 | Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors显示文摘 | Hirofumi Nakatomi Toshihiko Kuriu Shigeo Okabe Shin-ichi Yamamoto Osamu Hatano Nobutaka Kawahara Akira Tamura Takaaki Kirino Masato Nakafuku | 2002 | Cell2002，，4： | 2 |
| 15 | A Simple Prediction Formula of Roll Damping of Conventional Cargo Ships on the Basis of Ikeda's Method and Its Limitation显示文摘 | Yuki Kawahara Kazuya Maekawa Yoshiho Ikeda | 2012 | Journal of Shipping and Ocean Engineering2012，2，4： | 2 |
| 16 | Function of RNA-binding protein Musashi-1 in stem cells显示文摘 | Hideyuki Okano Hironori Kawahara Masako Toriya Keio Nakao Shinsuke Shibata Takao Imai | 2005 | Experimental Cell Research2005，，2： | 2 |
| 17 | Methane, Nitrous Oxide and Ammonia generation in full-scale swine wastewater purification facilities显示文摘 | Takashi Osada Makoto Shiraishi Teruaki Hasegawa Hirofumi Kawahara | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 2 |
| 18 | Endoscopic submucosal dissection for early gastric cancer: results and degrees of technical difficulty as well as success显示文摘 | A. Imagawa H. Okada Y. Kawahara R. Takenaka J. Kato H. Kawamoto S. Fujiki R. Takata T. Yoshino Y. Shiratori | 2006 | Endoscopy2006，，10： | 2 |
| 19 | The analysis of unsteady incompressible flows by a three-step finite element method显示文摘 | JIANG C B KAWAHARA M | 1993 | International Journal for Numerical Methods in Fluids1993，16，： | 2 |
| 20 | miR-218 on the genomic loss region of chromosome 4p15.31 functions asa tumor suppressor in bladder cancer显示文摘 | Shuichi Tatarano Takeshi Chiyomaru Kazumori Kawakami Hideki Enokida Hirofumi Yoshino Hideo Hidaka Takeshi Yamasaki Kazuya Kawahara Kenryu Nishiyama Naohiko Seki Masayuki Nakagawa | 2011 | International Journal of Oncology2011，，1： | 2 |
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